Changes in Doppler blood flow velocity in middle cerebral artery in response to airborne sound in low- and high-risk human fetuses

Dobrijevic, Lj.; Ljubić, Aleksandar; Sovilj, Mirjana; Ribarič-Jankes, Ksenija; Mikovic, Z.; Cerović, Nikola

doi:10.1016/j.ijporl.2009.06.022

Cited by 3 publications

(13 citation statements)

References 12 publications

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“…Evaluation of the fetal auditory system by recording changes in the fetal MCA blood flow after defined auditory stimulus tells us not only about functioning of the fetal auditory system, but also the degree of gross maturation of the central nervous system and general conditions in utero (Dobrijević et al, 2009). Several research groups have already demonstrated the link between fetal evoked responses to auditory stimuli and conditions during labor (Eswaran et al, 1999;Luz, 1985;Luz, Lima, Luz, & Feldens, 1980).…”

Section: Discussionmentioning

confidence: 99%

“…Defined acoustic stimulus was presented only once given that the repetition of the stimulus within the short period could lead to fetal habituation (Dobrijević et al, 2009;Morokuma et al, 2004). A recent study (Joy, McClure, Hepper, & Cooke, 2012) confirmed that the fetus could be habituated to repeated stimuli applied to the mother's abdomen during the third trimester of pregnancy.…”

Section: Prenatal Acoustic Screening (Pas) and Doppler Sonographymentioning

confidence: 99%

“…The RePi is representative of the percentage of PiR value change after normalization by PiB values. Dobrijević et al (2009) demonstrated that PAS measurements of RePi might be useful as indicators of psychophysiological development during the early postnatal period (Dobrijević et al, 2009;Plesinac et al, 2013).…”

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confidence: 99%

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Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Vujović¹,

Sovilj²,

Jeličić³

et al. 2017

Developmental Psychobiology

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This study investigated the correlation between maternal anxiety and blood flow changes through the fetal middle cerebral artery (MCA) after defined acoustic stimulation in 43 normotensive (C) and 40 gestational hypertensive (GH) subjects.Neonatal outcomes (gestational age at birth, Apgar score, birth weight) in the C and GH groups were analyzed. State (STAI-S) and trait (STAI-T) anxiety was assessed using Spielberger's questionnaire. The MCA blood flow was assessed once between 28 and 41 weeks of gestation using color Doppler ultrasound before and after application of defined acoustic stimulus. Relative size of the Pulsatility index (Pi) change (RePi) was calculated. The general hypotheses were: (1) women in GH group would have higher anxiety; (2) higher anxiety correlates with higher RePi change and poorer neonatal outcome; (3) fetuses from the GH group would have poorer neonatal outcome.Subjects from the GH group had higher STAI-T and RePi compared to the C group. A positive correlation between RePi and STAI-S, STAI-T, and systolic/diastolic blood pressure was found in both groups. There were more preterm deliveries in the GH group compared to the C group. A significant effect of STAI-T on body weight was observed in the C and GH group. There was a predictive effect of STAI-T and RePi on the C group, and STAI-S, STAI-T, diastolic blood pressure, and RePi on the GH group in terms of neonatal body weight. This study demonstrates an association between antenatal anxiety in GH women and increased fetal cerebral circulation in response to defined auditory stimulation. K E Y W O R D Sbirth outcomes, defined acoustic stimulation, fetal cerebral circulation, gestational hypertension, maternal anxiety

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Section: Discussionmentioning

confidence: 99%

Section: Prenatal Acoustic Screening (Pas) and Doppler Sonographymentioning

confidence: 99%

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Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Vujović¹,

Sovilj²,

Jeličić³

et al. 2017

Developmental Psychobiology

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“…Measured values of PI before (PIB) and few seconds after exposure to define digitalized generated sound stimulation (PIR 1) indicate changes in the fetal cerebral circulation. If the PI values after acoustical stimulation (PIR) are lower compared to the basic values of this index before stimulation (PIB), there is an increase in blood flow of fetal middle cerebral, while in the case of higher values of PIR compared to basic ones (PIB) signify reduction in blood flow in examined middle cerebral artery [1]. …”

Section: Methodsmentioning

confidence: 99%

“…It is based on a method of detecting fetal reactions on the defined sound stimulation [1]. However, the first idea of this method was proposed twenty years ago [2].…”

Section: Introductionmentioning

confidence: 99%

Fetus Sound Stimulation: Cilia Memristor Effect of Signal Transduction

Jankovic-Raznatovic

Dragojević-Dikić

Rakic

et al. 2014

BioMed Research International

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Background. This experimental study evaluates fetal middle cerebral artery (MCA) circulation after the defined prenatal acoustical stimulation (PAS) and the role of cilia in hearing and memory and could explain signal transduction and memory according to cilia optical-acoustical properties. Methods. PAS was performed twice on 119 no-risk term pregnancies. We analyzed fetal MCA circulation before, after first and second PAS. Results. Analysis of the Pulsatility index basic (PIB) and before PAS and Pulsatility index reactive after the first PAS (PIR 1) shows high statistical difference, representing high influence on the brain circulation. Analysis of PIB and Pulsatility index reactive after the second PAS (PIR 2) shows no statistical difference. Cilia as nanoscale structure possess magnetic flux linkage that depends on the amount of charge that has passed between two-terminal variable resistors of cilia. Microtubule resistance, as a function of the current through and voltage across the structure, leads to appearance of cilia memory with the “memristor” property. Conclusion. Acoustical and optical cilia properties play crucial role in hearing and memory processes. We suggest that fetuses are getting used to sound, developing a kind of memory patterns, considering acoustical and electromagnetically waves and involving cilia and microtubules and try to explain signal transduction.

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Fetal Middle Cerebral Artery Pulsatility Index in No-Risk Pregnancies: Effects of Auditory Stimulation and Pregnancy Order

Jeličić¹,

Janković

Sovilj³

et al. 2020

IJMS

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Pulsatility index (PI) values in a fetal middle cerebral artery (MCA) were compared in no-risk pregnancies to examine the differences related to auditory stimulation test and pregnancy order. The study included 196 women with no-risk pregnancies selected from the database of more than 1000 pregnant women divided into two groups. Group 1 consisted of 98 nulliparous women (C1 = 98) and Group 2 consisted of 98 parous women (C2 = 98). All pregnant women were of comparable age and fetal gestational age (GA) when MCA-PI values were recorded. Measurements of PI values in fetal MCA were obtained before and immediately after the application of fetal auditory stimulation test. The MCA-PI measuring was conducted in the period between the 36th and the 41st week of GA. The results showed that PI baseline values and PI values after defined auditory stimulation were significantly different when measured in nulliparous women compared to parous women (p = 0.001; p = 0.003, respectively), while no group differences were observed in relative PI value changes due to auditory stimulation. These findings suggest that hemodynamic changes in fetal MCA caused by defined auditory stimulation measured by PI value changes may be valuable in the assessment of fetal auditory perception functionality and its development.

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Changes in Doppler blood flow velocity in middle cerebral artery in response to airborne sound in low- and high-risk human fetuses

Cited by 3 publications

References 12 publications

Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Correlation between maternal anxiety, reactivity of fetal cerebral circulation to auditory stimulation, and birth outcome in normotensive and gestational hypertensive women

Fetus Sound Stimulation: Cilia Memristor Effect of Signal Transduction

Fetal Middle Cerebral Artery Pulsatility Index in No-Risk Pregnancies: Effects of Auditory Stimulation and Pregnancy Order

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