Changes in essential oil compositions, total phenol, flavonoids and antioxidant capacity of Achillea millefolium at different growth stages

Farhadi, Nasrin; Babaei, Khyrollah; Farsaraei, Sara; Moghaddam, Mohammad; Pirbalouti, Abdollah Ghasemi

doi:10.1016/j.indcrop.2020.112570

Cited by 77 publications

(45 citation statements)

References 26 publications

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“…2 TPC as mg GAE/g extract. 3 TEAC (Trolox Equivalent Antioxidant Capacity) as mmol Trolox/g extract. 4 ORAC (Oxygen Radical Absorbance Capacity) as mmol Trolox/g extract.…”

Section: Evaluation Of Tpc and Antioxidant Activity Of The Plant Extractsmentioning

confidence: 99%

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Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species

Villalva

Santoyo

Salas-Pérez

et al. 2021

Foods

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Melissa officinalis L. and Origanum majorana L., within Lamiaceae family, and Calendula officinalis L. and Achillea millefolium L., within the Asteraceae, have been considered a good source of bioactive ingredients with health benefits. In this study, the supercritical fluid extraction (SFE) using pure CO2, and the ultrasound assisted extraction (UAE) were proposed as green techniques to obtain plant-based extracts with potential antioxidant and anti-inflammatory activities. Higher values of total phenolic content and antioxidant activity were achieved in UAE ethanol:water (50:50, v/v) extracts. Meanwhile, UAE pure ethanol extracts showed greater anti-inflammatory activity. RP-HPLC-PAD-ESI-QTOF-MS/MS analysis showed a vast number of phenolic compounds in the extracts, including unreported ones. O. majorana ethanol:water extract presented the highest content of phenolics and antioxidant activity; among its composition, both rosmarinic acid and luteolin glucoside derivatives were abundant. The pure ethanol extract of A. millefolium resulted in an important content of caffeoylquinic acid derivatives, luteolin-7-O-glucoside and flavonoid aglycones, which could be related to the remarkable inhibition of TNF-α, IL-1β and IL-6 cytokines. Besides, borneol and camphor, found in the volatile fraction of A. millefolium, could contributed to this latter activity. Thus, this study points out that O. majorana and A. millefolium are considered a promising source of bioactive ingredients with potential use in health promotion.

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“…2 TPC as mg GAE/g extract. 3 TEAC (Trolox Equivalent Antioxidant Capacity) as mmol Trolox/g extract. 4 ORAC (Oxygen Radical Absorbance Capacity) as mmol Trolox/g extract.…”

Section: Evaluation Of Tpc and Antioxidant Activity Of The Plant Extractsmentioning

confidence: 99%

“…In this regard, the Lamiaceae and Asteraceae families represent a great source of valued plant species. These species are often used as flavoring ingredients in many culinary preparations, but are also considered as medicinal herbs, where their beneficial effects have been mainly related to phenolic compounds [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species

Villalva

Santoyo

Salas-Pérez

et al. 2021

Foods

View full text Add to dashboard Cite

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“…The production of phytochemicals in the plant metabolism is a dynamic process [47,48] and depends on several factors, including the vegetative period, collection year and time, and geographic locations [49][50][51][52]. Several studies have shown that both total and individual phenolic compounds have even changed in the same species due to geographical factors [37,39,53].…”

Section: Quantification Of Phytochemicalsmentioning

confidence: 99%

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

Zengin

Mahomoodally

et al. 2021

Antioxidants

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Epilobium hirsutum is extensively used as a traditional remedy in folk medicine, especially against prostate inflammation. Therefore, we evaluated the chemical profiles and biopharmaceutical potentials of different extracts of E. hirsutum aerial parts and roots. Metabolomic, antioxidant, and enzyme inhibitory profiles were investigated. Human prostate cancer PC3 cells were exposed to the extracts to evaluate antiproliferative effects. Gene expression and bioinformatics analyses were performed to investigate anti-inflammatory mechanisms. Oenothein B and myricetin were prominent compounds in the extracts. In scavenging/reducing assays, the methanol, infusion, and methanol/water extracts exhibited similar activities. We also observed the reduction of PC3 viability occurring following exposure to methanol and methanol/water extracts. According to bioinformatics analysis, myricetin was predicted to interact with COX-2 and TNFα. The interaction between TNFα and oxo-dihydroxy-octadecenoic acid was predicted as well. Intriguingly, the gene expression of COX-2 and TNFα was reduced in PC3 cells after exposure to methanol and methanol/water extracts. These effects were paralleled by the decreased gene expression of IL-8 and NFkB and the inhibition of PGE2 release. Therefore, the present findings suggest the potential use of E. hirsutum for the management of the burden of inflammation and oxidative stress occurring in lower urinary tract diseases, including prostatitis.

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“…The Achillea genus, one of the most important genera of the Asteraceae family with ethnopharmacological significance, consists of approximately 85 species mainly distributed in Middle East regions, such as Iran, Turkey, and Serbia and Eastern regions of Europe [ 1 ]. Achillea species have been reported to possess highly bioactive compounds and were rich in flavones and other flavonoids [ 2 ], non-saturated carboxylic acids [ 3 ], phenolic glycosides [ 4 ], guaianolides [ 5 ], lignans [ 6 ], phthalate derivatives [ 7 ], piperidine amides, proazulenes [ 8 ], sesquiterpenes [ 9 ], sesquiterpene lactone-diol [ 10 ], sesquiterpene lactones [ 11 ], polyacetylenes [ 12 ], spirodepressolide [ 13 ], tannins [ 14 ], and triterpene alkamide [ 15 ]. An ethnobotanical survey conducted by Mohammadnoseini and colleagues (2017) highlighted the use of several Achillea species in traditional medicine for the management of several ailments [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey

et al. 2021

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In the current study, Achillea santolinoides and Achillea aleppica aeral parts and root were extracted with ethyl acetate, methanol, and water. Detailed phytochemical profiles were obtained using UHPLC-MS, yielding the identification of hydroxybenzoic and hydroxycinnamic acids, phenolic acid glycosides and sugar esters, acylquinic acids, O-glycosyl flavones and flavonols, and flavonoid aglycons, among others. The antioxidant properties and enzyme inhibitory activities of the extracts were assayed with in vitro tests. The phenolic content of the water extracts was significantly higher as compared to the ethyl acetate and methanol ones. A. aleppica aerial parts methanol extract possessed highest flavonoid content (49.18 mg rutin equivalent/g). Antioxidant properties assessment revealed that the methanol extract of A. santolinoides roots actively scavenged DPPH (54.11 mg TE/g) and ABTS radicals (112.53 mg TE/g) and possessed highest reducing potential (183.55 and 129.92 mg TE/g, for CUPRAC and FRAP, respectively). The ethyl acetate extracts of aerial parts and roots of both species showed highest inhibition against BuCHE (6.07–6.76 mg GALAE/g). The ethyl acetate extract of A.santolinoides aerial part showed highest inhibition against tyrosinase (73.00 mg KAE/g). These results showed that the tested Achillea species might represent novel phytotherapeutic avenues for the management of Alzheimer’s disease and epidermal hyperpigmentation conditions, which are both associated with oxidative stress. This paper could shed light into future potential industrial applications using the tested Achillea species.

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Changes in essential oil compositions, total phenol, flavonoids and antioxidant capacity of Achillea millefolium at different growth stages

Cited by 77 publications

References 26 publications

Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species

Sustainable Extraction Techniques for Obtaining Antioxidant and Anti-Inflammatory Compounds from the Lamiaceae and Asteraceae Species

Shedding Light into the Connection between Chemical Components and Biological Effects of Extracts from Epilobium hirsutum: Is It a Potent Source of Bioactive Agents from Natural Treasure?

UHPLC-MS Characterization and Biological Insights of Different Solvent Extracts of Two Achillea Species (A. aleppica and A. santolinoides) from Turkey

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