Changes in heart rate variability during anaesthesia induction using sevoflurane or isoflurane with nitrous oxide

Abstract

Background: The purpose of this study was to compare cardiac sympathetic and parasympathetic balance using heart rate variability (HRV) during induction of anaesthesia between sevoflurane and isoflurane in combination with nitrous oxide. Methods: 40 individuals aged from 30 to 60 years, scheduled for general anaesthesia were equally divided into sevoflurane or isoflurane groups. After 100% oxygen inhalation for a few minutes, anaesthesia was induced with nitrous oxide 3 L min -1 , oxygen 3 L min -1 and sevoflurane or isoflurane. Sevoflurane or isoflurane concentration was increased by 0.5% every 2 to 3 breaths until 5% was attained for sevoflurane, or 3% for isoflurane. Vecuronium was administered to facilitate tracheal intubation. After intubation, sevoflurane was set to 2% while isoflurane was set to 1% with nitrous oxide with oxygen (1:1) for 5 min. Results: Both sevoflurane and isoflurane provoked a decrease in blood pressure, total power, the low frequency component (LF), and high frequency component (HF) of HRV. Although the heart rate increased during isoflurane anaesthesia, it decreased under sevoflurane. The power of LF and HF also decreased in both groups. LF was higher in the isoflurane group while HF was higher in the sevoflurane group. The LF/HF ratio increased transiently in the isoflurane group, but decreased in the sevoflurane group. Conclusion: Anaesthesia induction with isoflurane-nitrous oxide transiently increased cardiac sympathetic activity, while sevoflurane-nitrous oxide decreased both cardiac sympathetic and parasympathetic activities. The balance of cardiac parasympathetic/sympathetic activity was higher in sevoflurane anaesthesia.

Direct measurement of vagal tone in rats does not show correlation to HRV

“…With novel techniques for electrode manufacture and preparation described here, CNTYs are now easier to use and more reliable to implant. Anesthesia is also known to alter HRV and individual fiber dynamics [35][36][37][38][39][40][41][42][43] ; yet, vagal recordings have not been obtained under chronic conditions without anesthesia. For the first time, we have shown that vagal tone can be recorded using CNTY electrodes in awake, behaving rats, greatly expanding the scope of possible autonomic studies.…”

Operating Room Employees and Cardiotoxicity: Traditional Review

“…Uzun süreli düşük dozda bu ajanlara maruziyetin, ameliyathane personeline etkisi konusunda yeterli araştırmalar bulunmamaktadır. 3 Ameliyathanede sağlık çalışanlarının sürekli maruz kaldığı ve kardiyotoksisite oluşması açısından önemli olan etmenler aşağıda tartışılmıştır.…”

Electrocardiographic Scaling Reveals Differences in Electrocardiogram Interval Durations Between Marine and Terrestrial Mammals

“…However, in practice, ECGs are recorded under a variety of conditions with one of the most common being under anesthesia. Anesthesia can complicate comparisons because it is known to affect heart rate ( Picker et al, 2001 ; Nishiyama, 2016 ) and prolong QT intervals ( Yildirim et al, 2004 ). Hence, the effects of anesthesia must be accounted for in any comparison of cardiac electrophysiology.…”