Changes in hepatic perfusion assessed by dynamic contrast enhanced MRI, associated with morphologic evaluation, in patients with liver metastases from colorectal cancer treated with first-line chemotherapy

Abstract

Our results did not support the hypothesis of a predictive or prognostic role of HPI and AUCs calculated by DCE-MRI in liver metastatic CRC patients, thus the primary endpoint of the study was not reached. However, reduced arterial blood flow in metastatic liver can be obtained by chemotherapy alone, without any anti-angiogenic agent; interestingly, HPI and AUC data suggest a possible relationship between tumor metabolism and entire liver perfusion.

Advanced imaging to predict response to chemotherapy in colorectal liver metastases – a systematic review

“…Of these 45 articles, 29 were excluded, leaving 16 articles for inclusion. 10,11,[43][44][45][46][47][48][49][50][51][52][53][54][55][56] More information on the excluded articles and the reason for exclusion is available in the supplementary data.…”

“…Of the included studies, 12/16 studies had a low risk of selection bias. 10,11,44,45,47,48,[50][51][52][54][55][56] Selection bias was introduced in four studies due to unclear enrolment or inappropriate exclusions. 11,43,46,53 The most encountered quality issue concerned the reference standard (RECIST) and its blinding.…”

“…Of the 16 articles included, 11 studied a single modality 10,43,45,46,[48][49][50][51][52]54,55 and 5 studies compared two modalities. 11,44,47,53,56 In total, 5 articles studied FDG-PET, 11,44,50,53,56 1 article studied the FDG-PET-CT, 47 6 articles studied CT 43,[45][46][47]51,53 and 9 articles studied MRI.…”

“…11,44,47,53,56 In total, 5 articles studied FDG-PET, 11,44,50,53,56 1 article studied the FDG-PET-CT, 47 6 articles studied CT 43,[45][46][47]51,53 and 9 articles studied MRI. 10,11,44,48,49,52,[54][55][56] The number of patients ranged from 10 to 145 patients per study, with a total of 560 patients evaluated in all studies. The percentage of male patients varied from 54 to 80%.…”

“…The percentage of male patients varied from 54 to 80%. The reference standards/outcome measures were as follows: 11 studies used RECIST (1.1), 10,11,43,[46][47][48][49][50]52,53,55 5 studies used PFS, TTP and OS 44,45,50,54,56 and only one study used histology after surgery (tumour regression grade, TRG). 51 Individual study characteristics are presented in the supplementary data.…”