Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent

Heffron, Sean; Lin, BingXue; Parikh, Manish; Scolaro, Bianca; Adelman, Steven J.; Collins, Heidi L.; Berger, Jeffrey S.; Fisher, Edward A.

doi:10.1161/atvbaha.117.310102

Cited by 34 publications

(23 citation statements)

References 50 publications

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“…CSF CECs from SH-SY5Y, N9, and A172 cells were moderately to moderately strongly correlated with CSF concentrations of cholesterol, apo A-I, and clusterin. HDL CEC from macrophages correlates with plasma HDL cholesterol and apo A-I concentrations with similar strength in some studies and still independently associates with ASCVD and other disorders [18,44,45]. CSF CECs from N9 microglia and J774 macrophages agreed very well in appraising CEC of CSF samples, indicating that these cell types are very similar with respect to the usage of cholesterol acceptors in CSF, which is not surprising given the similarity of cell function.…”

Section: Discussionsupporting

confidence: 58%

Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease

Cipollari

Szapary

Picataggi

et al. 2020

JAD

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Section: Discussionsupporting

confidence: 58%

Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease

Cipollari

Szapary

Picataggi

et al. 2020

JAD

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“…Two recent studies have compared the effects on lipid profiles after RYGB and SG: Heffron and coworkers showed a similar weight loss after these two surgical techniques but a higher increase in HDL and ApoA after SG [ 43 ]; on the other hand, Maraninchi and coworkers also showed a similar weight loss after these two surgical techniques, with similar increases in HDL and reductions in triglycerides, but they showed a higher decrease in total cholesterol, LDL and ApoB after RYGB [ 44 ]. Although the effects of bariatric surgery on lipid profiles are clearly beneficial, small differences between surgical techniques need further studies due to small discrepancies which may be due to different selected populations and sample size of studies.…”

Section: Discussionmentioning

confidence: 99%

Beneficial changes on plasma apolipoproteins A and B, high density lipoproteins and oxidized low density lipoproteins in obese women after bariatric surgery: comparison between gastric bypass and sleeve gastrectomy

et al. 2018

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BackgroundThe beneficial effects in lipid profiles after obesity surgery might be associated with the decrease in cardiovascular risk. However, direct comparison between different surgical techniques has not been extensively performed.MethodsIn the present study we compare 20 obese women submitted to laparoscopic Roux en Y gastric bypass (RYGB) with 20 women submitted to sleeve gastrectomy (SG). Twenty control women matched for age and baseline cardiovascular risk were also included. Both patients and controls were followed up for 1 year after surgery or conventional treatment with diet and exercise, respectively. Lipid profiles were measured at baseline, 6 and 12 months later. Carotid intima-media thickness was measured by ultrasonography at baseline and at the end of the study.ResultsWomen submitted to bariatric surgery showed a decrease in total cholesterol, triglycerides, oxidized-LDL and ApoB, and an increase in HDL and ApoA concentrations that occurred regardless of the surgical procedure. LDL concentrations, however, decreased only after RYGB whereas Lp(a) showed no changes. We did not observe any correlation between the changes in serum lipid concentrations and those in carotid intima-media thickness.ConclusionsSleeve gastrectomy and gastric bypass induce a similar beneficial effect on serum lipids in women with high cardiovascular risk 1 year after surgery.

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“…Bariatric surgeries also lower triglycerides [69], as highlighted by recent publications [70–73]. Most weight loss interventions are also associated with increased HDL-cholesterol [67,68,70–73], and in the case of sleeve gastrectomy, this may be consequent to enhanced HDL cholesterol efflux capacity [74]. However, weight re-gain reverses the improvements in lipoproteins [67].…”

Section: Impact Of Diabetes On Lipoprotein Metabolismmentioning

confidence: 99%

Unexplained reciprocal regulation of diabetes and lipoproteins

Higuchi

Izquierdo

Haeusler

2018

Current Opinion in Lipidology

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Purpose of review Type 2 diabetes is associated with a characteristic dyslipidemia that may exacerbate cardiovascular risk. The causes of, and the effects of new antihyperglycemia medications on, this dyslipidemia, are under investigation. In an unexpected reciprocal manner, lowering LDL-cholesterol with statins slightly increases the risk of diabetes. Here we review the latest findings. Recent findings The inverse relationship between LDL-cholesterol and diabetes has now been confirmed by multiple lines of evidence. This includes clinical trials, genetic instruments using aggregate single nucleotide polymorphisms, as well as at least eight individual genes – HMGCR, NPC1L1, HNF4A, GCKR, APOE, PCKS9, TM6SF2, and PNPLA3 – support this inverse association. Genetic and pharmacologic evidence suggest that HDLcholesterol may also be inversely associated with diabetes risk. Regarding the effects of diabetes on lipoproteins, new evidence suggests that insulin resistance but not diabetes per se may explain impaired secretion and clearance of VLDL-triglycerides. Weight loss, bariatric surgery, and incretin-based therapies all lower triglycerides, whereas SGLT2 inhibitors may slightly increase HDL-cholesterol and LDL-cholesterol. Summary Diabetes and lipoproteins are highly interregulated. Further research is expected to uncover new mechanisms governing the metabolism of glucose, fat, and cholesterol. This topic has important implications for treating type 2 diabetes and cardiovascular disease.

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Changes in High-Density Lipoprotein Cholesterol Efflux Capacity After Bariatric Surgery Are Procedure Dependent

Cited by 34 publications

References 50 publications

Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease

Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer’s Disease

Beneficial changes on plasma apolipoproteins A and B, high density lipoproteins and oxidized low density lipoproteins in obese women after bariatric surgery: comparison between gastric bypass and sleeve gastrectomy

Unexplained reciprocal regulation of diabetes and lipoproteins

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