Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI

Wang, Liang; Zang, Yu‐Feng; He, Yong; Liang, Meng; Zhang, Xinqing; Tian, Lihong; Wu, Tao; Jiang, Tianzi; Li, Kuncheng

doi:10.1016/j.neuroimage.2005.12.033

Cited by 767 publications

(623 citation statements)

References 49 publications

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“…Additionally, two other recent studies (Wang et al 2006b;Allen et al 2007) independently investigated the hippocampal rsFC pattern in AD. Both of the studies found that the hippocampus exhibited disrupted rsFCs with extensive regions, including the PCC/PCu.…”

Section: Spatial Pattern Analysismentioning

confidence: 99%

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

et al. 2010

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As functional magnetic resonance imaging (fMRI) studies have yielded increasing amounts of information about the brain's spontaneous activity, they have revealed fMRI's potential to locate changes in brain hemodynamics that are associated with neuropsychiatric disorders. In this paper, we review studies that support the notion that changes in brain spontaneous activity observed by fMRI can be used as potential biomarkers for diagnosis and treatment evaluation in neuropsychiatric disorders. We first review the methods used to study spontaneous activity from the perspectives of (1) the properties of local spontaneous activity, (2) the spatial pattern of spontaneous activity, and (3) the topological properties of brain networks. We also summarize the major findings associated with major neuropsychiatric disorders obtained using these methods. Then we review the pilot studies that have used spontaneous activity to discriminate patients from normal controls. Finally, we discuss current challenges and potential research directions to further elucidate the clinical use of spontaneous brain activity in neuropsychiatric disorders.

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Section: Spatial Pattern Analysismentioning

confidence: 99%

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

et al. 2010

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“…The default network is active when engaged in internally focused tasks including autobiographical memory retrieval, envisioning the future, and conceiving the perspectives of others, with an MTL subsystem and a medial prefrontal subsystem that converge on important nodes of integration (Buckner et al, 2008). This network includes posterior cingulate and parietal lobe (Buckner, 2004(Buckner, , 2005Greicius et al, 2003Greicius et al, , 2004Wang et al, 2006). Greicius et al (2004) reported decreased default mode network activity in posterior cingulate and hippocampus of AD subjects that suggested disrupted connectivity between these areas.…”

Section: Animal Imagingmentioning

confidence: 99%

“…Greicius et al (2004) reported decreased default mode network activity in posterior cingulate and hippocampus of AD subjects that suggested disrupted connectivity between these areas. Wang et al (2006) reported disrupted connectivity between specific areas of hippocampus and prefrontal cortex, anterior cingulate, infero-temporal cortex, and cuneus that extended into precuneus and posterior cingulate areas.…”

Section: Animal Imagingmentioning

confidence: 99%

Molecular Brain Imaging in the Multimodality Era

Price

2012

J Cereb Blood Flow Metab

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Multimodality molecular brain imaging encompasses in vivo visualization, evaluation, and measurement of cellular/molecular processes. Instrumentation and software developments over the past 30 years have fueled advancements in multimodality imaging platforms that enable acquisition of multiple complementary imaging outcomes by either combined sequential or simultaneous acquisition. This article provides a general overview of multimodality neuroimaging in the context of positron emission tomography as a molecular imaging tool and magnetic resonance imaging as a structural and functional imaging tool. Several image examples are provided and general challenges are discussed to exemplify complementary features of the modalities, as well as important strengths and weaknesses of combined assessments. Alzheimer's disease is highlighted, as this clinical area has been strongly impacted by multimodality neuroimaging findings that have improved understanding of the natural history of disease progression, early disease detection, and informed therapy evaluation.

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“…Using a hypothesis-driven region of interest (ROI)-based approach, reduced resting state functional connectivity between the hippocampus, the PCC and other areas of the DMN was found in AD patients, with somewhat differing results between various studies, which may be attributed to methodological issues and patient selection (Allen et al, 2007;Wang et al, 2006;Wang et al, 2007). Functional connectivity between core DMN regions was also significantly reduced in cognitively intact elderly subjects harbouring increased fibrillar Aβ deposition in the brain, as revealed by combined resting state fMRI and amyloid-PET imaging (Hedden et al, 2009).…”

Section: Page 23 Of 58mentioning

confidence: 99%

Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease

Prvulovic

Bokde

Faltraco

et al. 2011

Progress in Neurobiology

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Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI

Cited by 767 publications

References 49 publications

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

Spontaneous brain activity observed with functional magnetic resonance imaging as a potential biomarker in neuropsychiatric disorders

Molecular Brain Imaging in the Multimodality Era

Functional magnetic resonance imaging as a dynamic candidate biomarker for Alzheimer's disease

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