Changes in hunger among pediatric patients with cancer and hematopoietic stem cell transplantation recipients

Loves, Robyn; Plenert, Erin; Tomlinson, Vivian; Palmert, Sasha; Green, Gloria; Schechter, Tal; Tomlinson, Deborah; Vettese, Emily; Zupanec, Sue; Dupuis, L. Lee; Sung, Lillian

doi:10.1007/s00520-020-05425-w

Cited by 5 publications

(2 citation statements)

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“…We planned to enroll between 10 and 40 children in each age cohort of 4‐7, 8‐10, 11‐14, and 15‐18 years of age, ensuring we enrolled equal numbers to each cohort. Based on our previous research, we anticipated requiring up to 40 participants within each age group to reach saturation 2,4,15‐17 . We evaluated whether the interview process required modification and whether saturation had occurred for the primary qualitative aim after each group of 12 dyads.…”

Section: Methodsmentioning

confidence: 99%

Discordance between pediatric self‐report and parent proxy‐report symptom scores and creation of a dyad symptom screening tool (co‐SSPedi)

et al. 2020

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Section: Methodsmentioning

confidence: 99%

Discordance between pediatric self‐report and parent proxy‐report symptom scores and creation of a dyad symptom screening tool (co‐SSPedi)

et al. 2020

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“…1 More recent studies have also highlighted the prevalence of changes in hunger and taste as bothersome symptoms in this population. [4][5][6][7] Symptoms are important because there is strong correlation between increasing symptom burden and worse quality of life. 8 Active symptom screening and reporting are likely to be central in optimising symptom control.…”

Section: Introductionmentioning

confidence: 99%

Translating the Symptom Screening in Paediatrics Tool (SSPedi) into North American Spanish and Among Spanish-speaking children receiving cancer treatments: evaluating understandability and cultural relevance in a multiple-phase descriptive study

et al. 2020

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ObjectivesSymptom screening is important to achieving symptom control. Symptom Screening in Paediatrics Tool (SSPedi) is validated for English-speaking children. Objectives were to translate SSPedi into Spanish, and to evaluate the understandability and cultural relevance of the translated version among Spanish-speaking children with cancer and paediatric haematopoietic stem cell transplant recipients.MethodsWe conducted a multiphase, descriptive study to translate SSPedi into Spanish. The first step was to determine whether one Spanish version would be appropriate for both North America and Argentina. Once this decision was made, forward and backward translations were performed. The translated version was evaluated by Spanish-speaking children 8–18 years of age receiving cancer treatments.Primary and secondary outcome measuresPrimary outcome was child self-reported difficulty with understanding of the entire instrument and each symptom using a 5-point Likert scale. Secondary outcomes were incorrect understanding of SSPedi items identified by cognitive interviews with the children using a 4-point Likert scale and cultural relevance, which was assessed qualitatively.ResultsThis report focuses on North American Spanish as a separate version will be required for Argentinian Spanish SSPedi based on different common vocabulary and grammatical structure. There were 20 children from Toronto and San Antonio included in cognitive interviews. The most common types of Spanish spoken were Mexican (13, 65%), Central American (2, 10%) and South American (2, 10%). No child reported that it was hard or very hard to complete Spanish SSPedi. Changes to the instrument itself were not required based on understanding or cultural relevance.ConclusionsWe translated and finalised Spanish SSPedi appropriate for use in North America. Future research will translate and evaluate SSPedi for use in Argentina and other Spanish-speaking countries.

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Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

Dupuis,

Vettese,

Grimes

et al. 2024

JAMA

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ImportancePediatric patients with cancer commonly experience severely bothersome symptoms. The effectiveness of routine symptom screening with symptom feedback and symptom management care pathways is unknown.ObjectiveTo determine whether thrice-weekly symptom screening with symptom feedback and management care pathways, compared with usual care, improves overall self-reported symptom scores measured by the Symptom Screening in Pediatrics Tool (SSPedi) in pediatric patients with cancer.Design, Setting, and ParticipantsThis cluster randomized trial enrolled participants between July 2021 and August 2023 from 20 pediatric cancer centers in the US. Patients newly diagnosed with cancer aged 8 to 18 years receiving any cancer treatment were included. Twenty sites were randomized to provide symptom screening (n = 10) vs usual care (n = 10); 221 participants were enrolled at intervention sites and 224 participants at control sites. The date of final follow-up was October 18, 2023.InterventionSymptom screening included providing thrice-weekly symptom screening prompts to participants, email alerts to the health care team, and locally adapted symptom management care pathway implementation.Main Outcomes and MeasuresThe primary outcome was self-reported total SSPedi score at week 8 (range, 0-60; higher scores indicate more bothersome). Secondary outcomes were Patient-Reported Outcomes Measurement Information System Fatigue score (mean [SD] score, 50 [10]; higher scores indicate more fatigue), Pediatric Quality of Life 3.0 Acute Cancer Module scores (range, 0-100; higher scores indicate better health), symptom documentation and interventions at week 8, and unplanned health care encounters.ResultsA total of 445 participants (median [range] age, 14.8 [8.1-18.9] years; 58.9% males) were enrolled. The mean (SD) 8-week SSPedi score was 7.9 (7.2) in the symptom screening group vs 11.4 (8.7) in the usual care group. Symptom screening was associated with significantly better 8-week total SSPedi scores (adjusted mean difference, −3.8 [95% CI, −6.4 to −1.2]) and less bothersome individual symptoms, with 12 of 15 symptoms being statistically significantly reduced. There was no difference in fatigue or quality of life. The mean (SD) number of emergency department visits was 0.77 (1.12) in the symptom screening group and 0.45 (0.81) in the usual care group. There were significantly more emergency department visits in the symptom screening group (rate ratio, 1.72 [95% CI, 1.03-2.87]).ConclusionsSymptom screening with symptom feedback and symptom management care pathways was associated with improved symptom scores and increased symptom-specific interventions. Future work should integrate symptom screening into routine clinical care.Trial RegistrationClinicalTrials.gov Identifier: NCT04614662

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Changes in hunger among pediatric patients with cancer and hematopoietic stem cell transplantation recipients

Cited by 5 publications

References 20 publications

Discordance between pediatric self‐report and parent proxy‐report symptom scores and creation of a dyad symptom screening tool (co‐SSPedi)

Discordance between pediatric self‐report and parent proxy‐report symptom scores and creation of a dyad symptom screening tool (co‐SSPedi)

Translating the Symptom Screening in Paediatrics Tool (SSPedi) into North American Spanish and Among Spanish-speaking children receiving cancer treatments: evaluating understandability and cultural relevance in a multiple-phase descriptive study

Symptom Screening Linked to Care Pathways for Pediatric Patients With Cancer

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