Changes in individual plasma amino acids following experimentally induced sand fly fever virus infection

Does infectious fever relieve autistic behavior by releasing glutamine from skeletal muscles as provisional fuel?

“…Lack of appetite (anorexia) induced by fever rapidly depletes glycogen stores, releasing glutamine and other amino acids from skeletal muscles to blood as substrate for glucose [44]. Fever may relieve autistic behavior simply by increasing brain temperature, metabolism, and blood flow.…”

“…Glutamine is substrate for glucose, also for citric acid cycle intermediates (e.g. a-ketoglutarate) that ammonia depletes [44,142]. Ammonia induces excitability, but also clouding of consciousness, a frontal lobe syndrome with loss of cortical oversight.…”

“…colonoscopy) relieved autistic behavior noticeably [52]. Such fasting [43], like anorexia of fever, rapidly breaks down muscle proteins to glutamine and other amino acids as provisional fuel [44,84]. Stress too releases muscle glutamine [85] but plasma glutamine decreases, apparently because cells require more glutamine under stress than muscles provide [86].…”

“…High temperature of fever breaks down muscle proteins to amino acids (catabolism) as metabolic fuel [44,50]. Sodium also carries glutamate into astrocytes for neutralization to glutamine, and activates the sodium pump, which requires conversion of glucose to lactate, a fuel neurons prefer [51].…”

Pathological and Biochemical Features of Legionella Pneumophila Infection in Guinea-pigs

“…These changes may be initiated by circulating substances elaborated by leucocytes in response to inflammatory processes (Wannemacher et al, 1972a); they include early changes in the concentrations of serum trace metals (Wannemacher et al, 1972a;Powanda et al, 1975;Hambleton et al, 1977Hambleton et al, , 1978 and amino acids that may be concerned with the subsequent synthesis of acute-phase proteins (Wannemacher et al, 19726;Powanda et al, 1975). Increases in the serum phenylalanine to tyrosine ratio also often precede inflammatory changes (Wannemacher et al, 1976;Hambleton et al, 1978).…”