Changes in intraocular pressure and central corneal thickness during pregnancy: a systematic review and Meta-analysis

Wang, Chao; Li, Ai Ling; Pang, Yu; Lei, Ying; Yu, Ling

doi:10.18240/ijo.2017.10.15

Cited by 15 publications

(21 citation statements)

References 30 publications

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“…In addition, Weinreb et al provided evidence that corneal thickness increases during pregnancy (Weinreb et al, 1988). Taken together, these reports indicate a strong association between corneal thickness and female hormonal regulation, in particular estrogens (Wang et al, 2017). However, it is not clear whether hormonal influence is exerted through direct interaction within the cornea, or via secondary effects such as systemic water retention by estrogen-induced upregulation of the renin-aldosterone system (Choudhary et al, 2017; Goldich et al, 2011).…”

Section: Sex Hormonesmentioning

confidence: 63%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

103

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Keratoconus (KC) is the most common ectatic corneal disease, with clinical findings that include discomfort, visual disturbance and possible blindness if left untreated. KC affects approximately 1:400 to 1:2000 people worldwide, including both males and females. The aetiology and onset of KC remains a puzzle and as a result, the ability to treat or reverse the disease is hampered. Sex hormones are known to play a role in the maintenance of the structure and integrity of the human cornea. Hormone levels have been reported to alter corneal thickness, curvature, and sensitivity during different times of menstrual cycle. Surprisingly, the role of sex hormones in corneal diseases and KC has been largely neglected. Prolactin-induced protein, known to be regulated by sex hormones, is a new KC biomarker that has been recently proposed. Studies herein discuss the role of sex hormones as a control mechanism for KC onset and progression and evidence supporting the view that prolactin-induced protein is an important hormonally regulated biomarker in KC is discussed.

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Section: Sex Hormonesmentioning

confidence: 63%

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Sharif

Bak‐Nielsen

Hjortdal

et al. 2018

Progress in Retinal and Eye Research

103

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“…Due to the major physiological changes in pregnancy, changes are seen in IOP, corneal thickness, and some visual functions such as accommodation and visual field [15]. In a recent meta-analysis, IOP values of healthy pregnant women in the third trimester have been shown to be lower than those of non-pregnant women [16]. The physiological [17].…”

Section: Discussionmentioning

confidence: 99%

Ocular perfusion pressure and intraocular pressure in pregnant women with severe preeclampsia

et al. 2018

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Objectives: The aim of this study was to investigate whether severe preeclampsia (SPE) affects intraocular pressure (IOP) and ocular perfusion pressure (OPP). Material and methods: This prospective and comparative study included 64 pregnant females, allocated into 2 groups as Group 1 (31 pregnant women with SPE) and Group 2 (33 normotensive pregnant women). IOP, systolic and diastolic blood pressure, OPP of all the subjects were measured after 20 weeks of gestation and prior to labor and medical therapy. Results: The mean IOP values in Group 1 were not significantly different from those of Group 2 (p = 0.528). The mean OPP values in Group 1 were significantly higher than those of Group 2 (p < 0.001). There was no significant correlation between IOP and OPP levels. No significant differences were determined between the groups in respect of age, gestational age body mass index (BMI) (p < 0.269, p < 0.219 and p < 0.556 respectively). The mean systolic and diastolic blood pressure values were statistically significantly higher in Group 1 than in Group 2 (p < 0.001 and p < 0.001). Conclusions: Although high IOP was expected in SPE patients, it was found to be constant. This could have been due to an increase in aqueous humor outflow because of changes occurring in angiogenic and anti-angiogenic factors in SPE.

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“…[ 39 40 ] Several studies have shown that serum levels of MMPs increase and serum levels of TIMPs decrease during pregnancy. [ 41 42 ] The increase in proteolytic enzymes and the decrease in their inhibitors during pregnancy must be correlated with the progression of keratoconus. Another example of this correlation is the report of rapid progression of keratoconus in a 49-year-old woman on selective tissue estrogen regulator (STEAR) therapy for endometriosis.…”

Section: Introductionmentioning

confidence: 99%

Keratoconus epidemiology

Gomes

Rodrigues

Lamazales

2022

Saudi Journal of Ophthalmology

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Keratoconus is an ectatic corneal disease that affects both men and women, usually at a young age. Risk factors such as eye rubbing, environmental and genetic factors contribute to its pathogenesis. Keratoconus presents a variable prevalence, being as high as 5% of the population in the Middle East. In this review, an English-language search for keratoconus epidemiology was undertaken using the PubMed database. We present and discuss the findings of the most relevant epidemiological studies on keratoconus and describe its characteristics and risk factors, correlating them with its pathogenesis.

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Changes in intraocular pressure and central corneal thickness during pregnancy: a systematic review and Meta-analysis

Abstract: A decrease in IOP is accompanied by an increase in CCT in the second and third trimesters of a normal pregnancy in women.

Cited by 15 publications

References 30 publications

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Pathogenesis of Keratoconus: The intriguing therapeutic potential of Prolactin-inducible protein

Ocular perfusion pressure and intraocular pressure in pregnant women with severe preeclampsia

Keratoconus epidemiology

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