Changes in intraocular pressure and ocular pulse amplitude of rhesus macaques after blue light scleral cross-linking

Liu, Chong; Yu, Li; Wang, Mengmeng; Li, Jing; Wang, Ningli; Zhang, Fengju

doi:10.1186/s12886-022-02306-0

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…However, this was manageable and successfully relieved with medication. The results of this study align with previous research conducted by other scholars [30] . Postoperatively, diplopia occurred in 5 eyes.…”

Section: Discussionsupporting

confidence: 92%

Efficacy of scleral buckling for the treatment of rhegmatogenous retinal detachment using a novel foldable capsular buckle

Fan,

Wang,

Wang

et al. 2024

Int J Ophthalmol

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AIM: To evaluate the effectiveness and safety of scleral buckling for the treatment of rhegmatogenous retinal detachment (RRD) using a novel foldable capsular buckle (FCB). METHODS: This was a series of case observation studies. Eighteen patients (18 eyes) who visited our ophthalmology department between August 2020 and August 2022 and were treated for RRD with scleral buckling using FCB were included. The procedure was similar to conventional scleral buckling, while a balloon-like FCB was placed onto the retinal break with balanced salt solution filling for a broad, external indentation instead of the silicone buckle. The retinal reattachment rate, best corrected visual acuity (BCVA), intraocular pressure (IOP), refractive dioptre and astigmatism degree, and complications were evaluated and recorded. RESULTS: There were 7 males and 11 females aged 19-58y. The average time course of RRD was 12d, ranging from 7-20d. The retinal break was located in the superior quadrants in 8 eyes and in the inferior quadrants in 10 eyes, with macula-off detachments in 12 eyes. The patients were followed-up for at least 6mo. The final retinal reattachment rate was 100%. The BCVA was significantly improved compared with the baseline (P<0.05). There was no significant change in refractive dioptre or astigmatism degree at each follow-up (all P>0.05). Three patients had transiently high IOPs within one week after surgery. Mild diplopia occurred in 5 patients after surgery and then disappeared after the balloon fluid was removed. CONCLUSION: The success rate of FCB scleral buckling for RRD is satisfactory. This procedure can be expected to be applied in new, uncomplicated cases of RRD.

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Section: Discussionsupporting

confidence: 92%

Efficacy of scleral buckling for the treatment of rhegmatogenous retinal detachment using a novel foldable capsular buckle

Fan,

Wang,

Wang

et al. 2024

Int J Ophthalmol

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“… 95 While another recent study in rhesus monkeys also suggested this method to be relatively benign, to date, the effectiveness of this approach in slowing myopia has not been demonstrated. 96 Scleral cross-linking could, in principle, be an effective means of myopia control, but safe techniques of inducing scleral cross-linking must be developed.…”

Section: Imi Digest—experimental Models Of Emmetropization and Myopiamentioning

confidence: 99%

IMI 2023 Digest

Sankaridurg

Berntsen

Bullimore

et al. 2023

Invest. Ophthalmol. Vis. Sci.

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Myopia is a dynamic and rapidly moving field, with ongoing research providing a better understanding of the etiology leading to novel myopia control strategies. In 2019, the International Myopia Institute (IMI) assembled and published a series of white papers across relevant topics and updated the evidence with a digest in 2021. Here, we summarize findings across key topics from the previous 2 years. Studies in animal models have continued to explore how wavelength and intensity of light influence eye growth and have examined new pharmacologic agents and scleral cross-linking as potential strategies for slowing myopia. In children, the term premyopia is gaining interest with increased attention to early implementation of myopia control. Most studies use the IMI definitions of ≤−0.5 diopters (D) for myopia and ≤−6.0 D for high myopia, although categorization and definitions for structural consequences of high myopia remain an issue. Clinical trials have demonstrated that newer spectacle lens designs incorporating multiple segments, lenslets, or diffusion optics exhibit good efficacy. Clinical considerations and factors influencing efficacy for soft multifocal contact lenses and orthokeratology are discussed. Topical atropine remains the only widely accessible pharmacologic treatment. Rebound observed with higher concentration of atropine is not evident with lower concentrations or optical interventions. Overall, myopia control treatments show little adverse effect on visual function and appear generally safe, with longer wear times and combination therapies maximizing outcomes. An emerging category of light-based therapies for children requires comprehensive safety data to enable risk versus benefit analysis. Given the success of myopia control strategies, the ethics of including a control arm in clinical trials is heavily debated. IMI recommendations for clinical trial protocols are discussed.

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Changes in intraocular pressure and ocular pulse amplitude of rhesus macaques after blue light scleral cross-linking

Cited by 2 publications

References 26 publications

Efficacy of scleral buckling for the treatment of rhegmatogenous retinal detachment using a novel foldable capsular buckle

Efficacy of scleral buckling for the treatment of rhegmatogenous retinal detachment using a novel foldable capsular buckle

IMI 2023 Digest

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