Changes in IOL power after laser peripheral iridotomy based on multivariate analysis

Abstract

Background This study aimed to investigate the effect of laser peripheral iridotomy (LPI) on intraocular lens (IOL) power in patients with primary angle closure disease (PACD), and to construct mathematical models to assess changes in IOL power. Methods This study included 58 eyes of PACD patients. IOL Master700 was used to analyze and compare the changes of IOL power and ocular related parameters in each formula before and after LPI. The number of cases with IOL power changes greater than 0.5 diopters (D) in each group were counted and significant differences were analyzed using Fisher’s exact test. Pearson’s linear correlation analysis was used to ascertain the relationship between IOL power changes and ocular parameter changes to establish mathematical models. Results No significant difference was found in calculated IOL power changes before and after LPI in each group. There was significant difference in the number of cases with IOL change values greater than 0.5D between the primary angle closure glaucoma (PACG) and the other two groups for each formula. IOL power changes were mainly associated with △K and △AL. Mathematical models of IOL power changes after LPI were constructed based on linear regression analysis.(PAC group: △IOL Haigis =0.026–2.950×△AL-1.414×△K, △IOL Hoffer Q =-3.578×△AL-1.412×△K, △IOL SRK/T =-3.152×△AL-1.114×△K, △IOL Holladay 1 =-3.405×△AL-1.291×△K, △IOL Holladay 2 =-3.467×△AL-1.483×△K, △IOL BUII =-3.185×△AL-1.301×△K; PACG group:△IOL Haigis =-1.632×△K, △IOL Hoffer Q =-3.770×△AL-1.434×△K, △IOL SRK/T =-3.427×△AL-1.102×△K, △IOL Holladay 1 =-3.625×△AL-1.278×△K, △IOL Holladay 2 =-4.764×△AL-1.272×△K, △IOL BUII =-4.935×△AL-1.304×△K). Conclusions LPI will cause changes in some ocular parameters in patients with PACD, with great effects on IOL power calculations was observed in patients with PACG. Mathematical models based on multivariate analysis hold promise for predicting IOL power changes subsequent to LPI.