2014
DOI: 10.1155/2014/706074
|View full text |Cite
|
Sign up to set email alerts
|

Changes in Iron Metabolism and Oxidative Status in STZ-Induced Diabetic Rats Treated with Bis(maltolato) Oxovanadium (IV) as an Antidiabetic Agent

Abstract: The role of vanadium as a micronutrient and hypoglycaemic agent has yet to be fully clarified. The present study was undertaken to investigate changes in the metabolism of iron and in antioxidant defences of diabetic STZ rats following treatment with vanadium. Four groups were examined: control; diabetic; diabetic treated with 1 mgV/day; and Diabetic treated with 3 mgV/day. The vanadium was supplied in drinking water as bis(maltolato) oxovanadium (IV) (BMOV). The experiment had a duration of five weeks. Iron w… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
22
0
1

Year Published

2014
2014
2023
2023

Publication Types

Select...
7

Relationship

1
6

Authors

Journals

citations
Cited by 14 publications
(25 citation statements)
references
References 32 publications
2
22
0
1
Order By: Relevance
“…In turn, this facilitates Fe sequestration in the tissues and may be related to an attempt by the organism to control the oxidative stress associated with exposure to the metal . Fe overload in the tissues in response to exposure to V has been observed by other authors in studies of nondiabetic rats (Thompson et al, 2002;Scibior et al, 2012Scibior et al, , 2014 and of diabetic rats (Sánchez-González et al, 2014).…”
Section: Discussionsupporting
confidence: 69%
See 1 more Smart Citation
“…In turn, this facilitates Fe sequestration in the tissues and may be related to an attempt by the organism to control the oxidative stress associated with exposure to the metal . Fe overload in the tissues in response to exposure to V has been observed by other authors in studies of nondiabetic rats (Thompson et al, 2002;Scibior et al, 2012Scibior et al, , 2014 and of diabetic rats (Sánchez-González et al, 2014).…”
Section: Discussionsupporting
confidence: 69%
“…It is generally agreed that the increased intake of V leads to Fe overload, mainly in the spleen and liver (Thompson et al, 2002;Scibior et al, 2012;Sánchez-González et al, 2014), together with a deterioration in haematological parameters (Domingo et al, 1995;Scibior et al, 2006;Sánchez-González et al, 2012a).…”
Section: Introductionmentioning
confidence: 99%
“…Thus, the PT is presented with more iron to reabsorb, which in at least a third of humans results in PT iron deposition (11). Interestingly, in the streptozotocin-induced diabetic rat, there is a 4-fold increase in urinary iron excretion (32), an increase in renal TfR1 expression, and decreased DMT1 expression (33). Clearly, when diseased, the kidney responds to the altered filtrate that it is confronted with, and in the future it will be beneficial to understand and possibly manipulate this response to preserve the life of failing kidneys.…”
Section: Discussionmentioning
confidence: 99%
“…Both GSH and GSSG have been shown to be reasonably potent binders of VO +2 [129,[175][176][177]. Other effective reducing agents, such as NAD + /NADH, NADP + /NADPH, FAD + /FADH, or ascorbate, may interconvert V 5+ and V 4+ , as well as V 3+ species [18,[178][179][180].…”
Section: Interconversion Between Vanadium Species and Cellular Redox mentioning
confidence: 99%