Changes in Lesional and Non-lesional Skin Microbiome During Treatment of Atopic Dermatitis

Kwon, Song; Choi, Ji Young; Shin, Jung Won; Huh, Chang Hun; Park, Kyoung Chan; Du, Mi Hee; Yoon, Sungroh; Na, Jung Im

doi:10.2340/00015555-3089

Cited by 53 publications

(65 citation statements)

References 22 publications

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“…However, similarly to other studies [ 3 , 23 , 26 , 32 , 52 , 53 , 54 ], no significant differences in bacterial alpha diversity were found between allergic and non-allergic infants, regardless of the type of allergy or compartment, i.e., skin or feces. These results suggest that, contrary to results obtained for older patients [ 29 , 55 ], decreased diversity does not appear to be related to allergy symptoms, even in the case of AD. This might be due to the fact that the microbial community is still developing in young infants; nevertheless, this observation indicates that neither species richness nor diversity can be used as predictors of allergy in infants under one year of age.…”

Section: Discussioncontrasting

confidence: 99%

A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

et al. 2021

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The gut microbiota in patients with food allergy, and the skin microbiota in atopic dermatitis patients differ from those of healthy people. We hypothesize that relationships may exist between gut and skin microbiota in patients with allergies. The aim of this study was to determine the possible relationship between gut and skin microbiota in patients with allergies, hence simultaneous analysis of the two compartments of microbiota was performed in infants with and without allergic symptoms. Fifty-nine infants with food allergy and/or atopic dermatitis and 28 healthy children were enrolled in the study. The skin and gut microbiota were evaluated using 16S rRNA gene amplicon sequencing. No significant differences in the α-diversity of dermal or fecal microbiota were observed between allergic and non-allergic infants; however, a significant relationship was found between bacterial community structure and allergy phenotypes, especially in the fecal samples. Certain clinical conditions were associated with characteristic bacterial taxa in the skin and gut microbiota. Positive correlations were found between skin and fecal samples in the abundance of Gemella among allergic infants, and Lactobacillus and Bacteroides among healthy infants. Although infants with allergies and healthy infants demonstrate microbiota with similar α-diversity, some differences in β-diversity and bacterial species abundance can be seen, which may depend on the phenotype of the allergy. For some organisms, their abundance in skin and feces samples may be correlated, and these correlations might serve as indicators of the host’s allergic state.

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Section: Discussioncontrasting

confidence: 99%

A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

et al. 2021

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“…A drastic increase in microbial diversity and decrease of S. aureus proportion were observed with clinical improvement of AD. The UVB treatment did not exert additive effects on the improvement of AD; however, it seemed to reduce AD recurrence [42].…”

Section: Narrowband Ultraviolet B (Uvb) Phototherapymentioning

confidence: 77%

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Wan

Chen

2020

Dermatol Ther (Heidelb)

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Atopic dermatitis (AD) is a chronic common inflammatory skin disorder with clinical characteristics of pruritic, dry, and recurrent flares that involve the whole body. Recent studies have demonstrated that the skin microbiota, characterized by an overgrowth of Staphylococcus aureus (S. aureus), plays a critical role in the manifestation of AD. There is striking evidence that skin microbiota can modulate the development and progression of AD. Therefore, more and more therapeutic approaches are adopted for modifying skin microbiota. Here we discuss the role of skin microbiota in the etiology and maintenance of AD; furthermore, we summarize the effects of therapeutic treatments on skin microbiota in AD based on published literature. With the help of the theoretical guidance suggested by microbial metagenome analysis, the reconstitution of microbiota should be a promising way to harness the pathogens of AD and could be used as a brandnew therapeutic strategy in clinical trials. We believe that the targeted therapy of dysbiosis in AD may possibly become a unique approach to an integrated treatment program in the near future.

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“…Kwon et al, evaluated changes in lesional and non-lesional skin microbiota during AD treatment (narrow band ultraviolet B (NBUVB) phototherapy and topical corticosteroids versus. topical corticosteroids alone) to find a drastic increase in microbial diversity and decrease in S. aureus proportion on lesional skin after treatment [85]. Shannon diversity of non-lesional skin of the NBUVB + topical corticosteroids group increased at week 6 while that of the topical corticosteroids alone population remained similar.…”

Section: Skin Microbiota and Admentioning

confidence: 99%

Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies

Kim

2019

JCM

169

124

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Atopic dermatitis (AD) is a long-standing inflammatory skin disease that is highly prevalent worldwide. Multiple factors contribute to AD, with genetics as well as the environment affecting disease development. Although AD shows signs of skin barrier defect and immunological deviation, the mechanism underlying AD is not well understood, and AD treatment is often very difficult. There is substantial data that AD patients have a disturbed microbial composition and lack microbial diversity in their skin and gut compared to controls, which contributes to disease onset and atopic march. It is not clear whether microbial change in AD is an outcome of barrier defect or the cause of barrier dysfunction and inflammation. However, a cross-talk between commensals and the immune system is now noticed, and their alteration is believed to affect the maturation of innate and adaptive immunity during early life. The novel concept of modifying skin and gut microbiome by applying moisturizers that contain nonpathogenic biomass or probiotic supplementation during early years may be a preventive and therapeutic option in high risk groups, but currently lacks evidence. This review discusses the nature of the skin and gut flora in AD, possible mechanisms of skin–gut interaction, and the therapeutic implications of microbiome correction in AD.

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Changes in Lesional and Non-lesional Skin Microbiome During Treatment of Atopic Dermatitis

Cited by 53 publications

References 22 publications

A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study

A Calm, Dispassionate Look at Skin Microbiota in Atopic Dermatitis: An Integrative Literature Review

Microbiome of the Skin and Gut in Atopic Dermatitis (AD): Understanding the Pathophysiology and Finding Novel Management Strategies

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