Changes in liver and spleen volume in alcoholic liver fibrosis of man.

Tarao, Kazuo; Matsumoto, Shigehiko; Okada, Kenzo; Oikawa, Yubo; Tamai, Setsuo; Imori, Kazuto; Miyamoto, Shigeo; Kazato, K.; Unayama, Shiro; Sakurai, Akira; Hayashi, Kazuhiro; Ikeda, Toshio; Uchikoshi, Toshiyuki; Hoshino, Hiroshi

doi:10.2957/kanzo.28.1051

Cited by 3 publications

(6 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study showed that LV in patients with liver fibrosis tended to increase with the severity of fibrosis from stage 0 to 3, but decrease at stage 4 (). The increasing volume of liver with the progress of liver fibrosis from stage 0 to 3 was perhaps due to the ballooning of hepatocytes along with increased fibrotic components (). However, in advanced fibrosis, LV gradually decreased because of the segmental or global liver atrophy ().…”

Section: Discussionmentioning

confidence: 99%

“…According to other studies (), the authors evaluated the enlargement of spleen in liver fibrosis and did not take liver inflammation into consideration. Not considering inflammation affecting enlargement of the spleen as in these published articles (), we performed this study initially focusing on using multiple parameters on MRI for measuring the enlargement of spleen to stage liver fibrosis. Our future study will focus on how to discriminate between liver fibrosis and inflammation affecting enlargement of the spleen.…”

Section: Discussionmentioning

confidence: 99%

“…Third, both liver fibrosis and inflammation might contribute to increased portal pressure, finally resulting in enlargement of the spleen, and we have not differentiated between the two in this study. According to other studies (6,33,34), the authors evaluated the enlargement of spleen in liver fibrosis and did not take liver inflammation into consideration. Not considering inflammation affecting enlargement of the spleen as in these published articles (6,33,34), we performed this study initially focusing on using multiple parameters on MRI for measuring the enlargement of spleen to stage liver fibrosis.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Spleen size measured on enhanced mri for quantitatively staging liver fibrosis in minipigs

Chen

et al. 2013

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Spleen size measured on enhanced mri for quantitatively staging liver fibrosis in minipigs

Chen

et al. 2013

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…Splenomegaly is often used radiologically as an indicator of cirrhosis. It has been shown that portal venous pressure positively correlates with spleen size . Therefore, we evaluated the usefulness of splenic perfusion and spleen size in assessing the degree of liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

“…It has been shown that portal venous pressure positively correlates with spleen size. [8][9][10][11][12] Therefore, we evaluated the usefulness of splenic perfusion and spleen size in assessing the degree of liver fibrosis. The aim of this study was to pinpoint the extent to which splenic perfusion indicates the degree of liver fibrosis and to enhance the usefulness of splenic perfusion, evaluated by means of dynamic computed tomography (CT), and of spleen size, in assessing the degree of liver fibrosis.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis

Suzuki

Yamada

Komatsu

et al. 2017

Hepatology Research

View full text Add to dashboard Cite

Aim:To enhance the usefulness of splenic perfusion evaluated by means of dynamic computed tomography (CT) and spleen size in assessing the degree of liver fibrosis. Methods:We retrospectively studied 133 patients who had undergone dynamic CT before hepatectomy. Fibrosis was histologically established in all. First we calculated splenic perfusion parameters K 1 (inflow rate constant), 1/k 2 (mean transit time; MTT), and K 1 /k 2 (distribution volume; V d ), using compartment model analysis. Then we compared the stage of fibrosis with splenic perfusion and spleen size (long axis, R), using the Kruskal-Wallis test and multiple comparisons. After that, we assessed the diagnostic accuracy of the combination of splenic perfusion, spleen size, age, gender, and the presence or absence of hepatitis B and hepatitis C viral infection in detecting liver fibrosis, using stepwise regression and receiver operating characteristic analysis.Results: Significant differences (P < 0.05) in MTT were observed in comparisons between fibrosis stages F0 and F4, between F1 and F4, and between F2 and F4. Significant differences (P < 0.05) in R were observed in comparisons between F0 and F4, and between F1 and F4. Considering the presence or absence of hepatitis B and C viral infection along with MTT and R, the areas under the receiver operating characteristic curves were 0.89 for ≥F1, 0.83 for ≥F2, 0.82 for ≥F3, and 0.82 for F4.Conclusion: Splenic MTT and spleen size are helpful in assessing liver fibrosis.

show abstract

Liver segmental volume and attenuation ratio (LSVAR) on portal venous CT scans improves the detection of clinically significant liver fibrosis compared to liver segmental volume ratio (LSVR)

et al. 2020

View full text Add to dashboard Cite

Background The aim of this proof-of-concept study was to show that the liver segmental volume and attenuation ratio (LSVAR) improves the detection of significant liver fibrosis on portal venous CT scans by adding the liver vein to cava attenuation (LVCA) to the liver segmental volume ratio (LSVR). Material and methods Patients who underwent portal venous phase abdominal CT scans and MR elastography (reference standard) within 3 months between 02/2016 and 05/2017 were included. The LSVAR was calculated on portal venous CT scans as LSVR*LVCA, while the LSVR represented the volume ratio between Couinaud segments I-III and IV-VIII, and the LVCA represented the density of the liver veins compared to the density in the vena cava. The LSVAR and LSVR were compared between patients with and without significantly elevated liver stiffness (based on a cutoff value of 3.5 kPa) using the Mann–Whitney U test and ROC curve analysis. Results The LSVR and LSVAR allowed significant differentiation between patients with (n = 19) and without (n = 122) significantly elevated liver stiffness (p < 0.001). However, the LSVAR showed a higher area under the curve (AUC = 0.96) than the LSVR (AUC = 0.74). The optimal cutoff value was 0.34 for the LSVR, which detected clinically increased liver stiffness with a sensitivity of 53% and a specificity of 88%. With a cutoff value of 0.67 for the LSVAR, the sensitivity increased to 95% while maintaining a specificity of 89%. Conclusion The LSVAR improves the detection of significant liver fibrosis on portal venous CT scans compared to the LSVR.

show abstract

Changes in liver and spleen volume in alcoholic liver fibrosis of man.

Cited by 3 publications

References 12 publications

Spleen size measured on enhanced mri for quantitatively staging liver fibrosis in minipigs

Spleen size measured on enhanced mri for quantitatively staging liver fibrosis in minipigs

Evaluation of splenic perfusion and spleen size using dynamic computed tomography: Usefulness in assessing degree of liver fibrosis

Liver segmental volume and attenuation ratio (LSVAR) on portal venous CT scans improves the detection of clinically significant liver fibrosis compared to liver segmental volume ratio (LSVR)

Contact Info

Product

Resources

About