Changes in lower limb muscle cross‐sectional area and tissue fluid volume after transition from standing to supine

Berg, Hans E.; Tedner, B.; Tesch, Per A.

doi:10.1111/j.1748-1716.1993.tb09573.x

Cited by 314 publications

(254 citation statements)

References 17 publications

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“…The probe was coated with a water-soluble transmission gel to provide acoustic contact without depressing the dermal surface and was aligned perpendicular to the muscle. Before any assessment, subjects rested in a supine position for 20 min to allow fluid shifts to occur (Berg et al 1993). Measurements were taken between 3 and 5 days after the last session to prevent swelling from contributing to the MT.…”

Section: Ultrasound Measurementsmentioning

confidence: 99%

Time course of low- and high-volume strength training on neuromuscular adaptations and muscle quality in older women

Radaelli

Botton

Wilhelm

et al. 2014

AGE

109

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This study investigated the effects of low-and high-volume strength trainings on neuromuscular adaptations of lower-and upper-body muscles in older women after 6 weeks (6WE), 13 weeks (13WE), and 20 weeks (20WE) of training. Healthy older women were assigned to low-volume (LV) or high-volume (HV) training groups. The LV group performed one set of each exercise, while the HV group performed three sets, 2 days/ week. Knee extension and elbow flexion one-repetition maximum (1-RM), maximal isometric strength, maximal muscle activation, and muscle thickness (MT) of the lower-and upper-body muscles, as well as lower-body muscle quality (MQ) obtained by ultrasonography, were evaluated. Knee extension and elbow flexion 1-RM improved at all time points for both groups; however, knee extension 1-RM gains were greater for the HV group after 20WE. Maximal isometric strength of the lower body for both groups increased only at 20WE, while upper-body maximal isometric strength increased after 13WE and 20WE. Maximal activation of the lower and upper body for both groups increased only after 20WE. Both groups showed significant increases in MT of their lower and upper body, with greater gains in lower-body MT for the HV group at 20WE. MQ improved in both groups after 13WE and 20WE, whereas the HV group improved more than the LV group at 20WE. These results showed that low-and high-volume trainings have a similar adaptation time course in the muscular function of upper-body muscles. However, high-volume training appears to be more efficient for lower-body muscles after 20 weeks of training.

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Section: Ultrasound Measurementsmentioning

confidence: 99%

Time course of low- and high-volume strength training on neuromuscular adaptations and muscle quality in older women

Radaelli

Botton

Wilhelm

et al. 2014

AGE

109

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“…Subjects rested in the supine horizontal position for 1 h prior to scanning to prevent the influence of fluid shifts on muscle volume (1).…”

Section: Muscle Volumementioning

confidence: 99%

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Trappe

Carroll

Dickinson

et al. 2011

American Journal of Physiology-Regulatory, Integrative and Comp

162

215

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Trappe TA, Carroll CC, Dickinson JM, LeMoine JK, Haus JM, Sullivan BE, Lee JD, Jemiolo B, Weinheimer EM, Hollon CJ. Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults. Am J Physiol Regul Integr Comp Physiol 300: R655-R662, 2011. First published December 15, 2010; doi:10.1152/ajpregu.00611.2010.-Evidence suggests that consumption of over-the-counter cyclooxygenase (COX) inhibitors may interfere with the positive effects that resistance exercise training has on reversing sarcopenia in older adults. This study examined the influence of acetaminophen or ibuprofen consumption on muscle mass and strength during 12 wk of knee extensor progressive resistance exercise training in older adults. Thirty-six individuals were randomly assigned to one of three groups and consumed the COX-inhibiting drugs in double-blind placebo-controlled fashion: placebo (67 Ϯ 2 yr; n ϭ 12), acetaminophen (64 Ϯ 1 yr; n ϭ 11; 4 g/day), and ibuprofen (64 Ϯ 1 yr; n ϭ 13; 1.2 g/day). Compliance with the resistance training program (100%) and drug consumption (via digital video observation, 94%), and resistance training intensity were similar (P Ͼ 0.05) for all three groups. Drug consumption unexpectedly increased muscle volume (acetaminophen: 109 Ϯ 14 cm 3 , 12.5%; ibuprofen: 84 Ϯ 10 cm 3 , 10.9%) and muscle strength (acetaminophen: 19 Ϯ 2 kg; ibuprofen: 19 Ϯ 2 kg) to a greater extent (P Ͻ 0.05) than placebo (muscle volume: 69 Ϯ 12 cm 3 , 8.6%; muscle strength: 15 Ϯ 2 kg), when controlling for initial muscle size and strength. Follow-up analysis of muscle biopsies taken from the vastus lateralis before and after training showed muscle protein content, muscle water content, and myosin heavy chain distribution were not influenced (P Ͼ 0.05) by drug consumption. Similarly, muscle content of the two known enzymes potentially targeted by the drugs, COX-1 and -2, was not influenced (P Ͼ 0.05) by drug consumption, although resistance training did result in a drug-independent increase in COX-1 (32 Ϯ 8%; P Ͻ 0.05). Drug consumption did not influence the size of the nonresistance-trained hamstring muscles (P Ͼ 0.05). Over-thecounter doses of acetaminophen or ibuprofen, when consumed in combination with resistance training, do not inhibit and appear to enhance muscle hypertrophy and strength gains in older adults. The present findings coupled with previous short-term exercise studies provide convincing evidence that the COX pathway(s) are involved in the regulation of muscle protein turnover and muscle mass in humans.cyclooxygenase; prostaglandin; sarcopenia SARCOPENIA, DEFINED AS THE loss of skeletal muscle mass, is a debilitating clinical condition associated with old age (13,40). This age-related loss of muscle mass is associated with a loss of muscle strength and function, a reduced functional independence, and a financial burden to the US healthcare system estimated at $20 billion per year (19,23,24,51). One of the most proven treatments for sarcopenia is resistance exercise training, which in...

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“…Scans were obtained after 30-60 min of bed rest to minimize the influence of postural fluid shifts on muscle CSA (Berg et al 1993). Radiation dose was minimized by limiting scan volumes via anatomical landmarks on scout images ( Figure).…”

Section: Computed Tomographymentioning

confidence: 99%

Reduced muscle radiological density, cross-sectional area, and strength of major hip and knee muscles in 22 patients with hip osteoarthritis

Rasch¹,

Byström

Dalén³

et al. 2007

Acta Orthopaedica

187

155

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Background Patients with hip osteoarthritis (OA) typically suffer joint pain, and often experience muscular weakness. We hypothesized that substantial atrophy would manifest in multiple muscle groups along the affected limb, resulting in severe muscle dysfunction.Patients and methods We assessed 22 elderly patients with unilateral OA for maximal voluntary isometric strength of hip and knee muscles using a dynamometer that was developed for the purpose. Cross-sectional area (CSA) and radiological density (RD; in Hounsfield units: HU) of hip and knee muscles were assessed using CT. We determined SF-36, HHS, and EQ-5D.Results Hip extension, flexion, adduction, abduction, and knee extension strength were reduced (11-29%; p < 0.01) in the OA limb relative to the healthy limb. Muscle CSA of hip extensors, flexors, adductors, knee extensors and flexors, but not hip abductors, was reduced (11-19%; p < 0.01) in the OA limb, where RD of all muscle groups except hip flexors was reduced (5-15 HU; p < 0.01). The clinical scores confirmed impairment.Interpretation Major muscles functioning around the hip and knee showed substantial loss of strength and mass, which contributes to the reduced ambulatory capacity of OA patients. Reduced muscle CSA could not fully explain the loss in strength. Infiltration with fat or other non-contractile components, as indicated by a reduced RD, in OA limb muscles was substantial.

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Changes in lower limb muscle cross‐sectional area and tissue fluid volume after transition from standing to supine

Cited by 314 publications

References 17 publications

Time course of low- and high-volume strength training on neuromuscular adaptations and muscle quality in older women

Time course of low- and high-volume strength training on neuromuscular adaptations and muscle quality in older women

Influence of acetaminophen and ibuprofen on skeletal muscle adaptations to resistance exercise in older adults

Reduced muscle radiological density, cross-sectional area, and strength of major hip and knee muscles in 22 patients with hip osteoarthritis

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