Changes in mouse hepatocytes caused by vincamin

Abstract

Mouse liver was examined following a single intraperitoneal application of 25 mg/kg body weight vincamine. The studies were made using the technique of thin-sectioning for electron microscopy as well as the freeze-fracture method. The thin-sectioning technique was useful for observing discrete changes such as an increase in the mitochondria and alterations in the bile canaliculi, e.g. a loss of microvilli and dilatation of the lumen. No other cytoplasmic changes could be observed. It was only with the aid of the freeze-fracture method that alterations in the cell contacts became visible. In contrast to the control animals the tight junctions in the liver tissue of mice treated with vincamin were disorganized and irregularly arranged. The gap junctions showed a very irregular contour as well. The question arises as to the extent to which the freeze-fracture method should be applied in the testing of pharmaceuticals, so as to exclude the possibility of damage to membranes.

Vincamine Modulates the Effect of Pantoprazole in Renal Ischemia/Reperfusion Injury by Attenuating MAPK and Apoptosis Signaling Pathways

“…Vincamine, particularly in the brain, has a selective vasoregulatory effect on the microcapillary circulation. This peripheral vasodilator action enhances the brain's blood supply and is used as a nootropic agent to regulate aging signs [26]. It also acts as a brain metabolic stimulator by improving glucose utilization, adenosine triphosphate (ATP) generation, oxygen utilization, and offering better protection against hypoxia and cerebral ischemia.…”

Vincamine alleviates amyloid-β 25-35 peptides-induced cytotoxicity in PC12 cells

“…[ 22 ] It is employed today in the therapy of cerebral metabolic and circulatory disorders since it combines cerebrometabolic and hemodynamic properties. [ 23 24 25 26 ] Twenty years before, it was used as a drug for treating memory impairments. Vinpocetine, a vincamine derivativeefficiently protects cells from reactive oxygen species (ROS) attack.…”

Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next‐Generation Therapeutics

“…Vincamine is a commercially available medicinal agent used to enhance regional and systemic blood flow of the cardiovascular system. [84][85][86] Huigens et al employed different ring distortion pathways using this NP, which led to the generation of a pilot collection of stereochemically and skeletally diverse scaffolds (Scheme 2). [37,87] In the presence of methyl propionate, the tertiary amine moiety of vincamine (8) induced ring cleavage affording compound 9 (Scheme 2).…”

“…Another interesting application of the CtD strategy was recently reported by Huigens and his coworkers using the monoterpene indole alkaloid vincamine ( 8 ) as a starting material. Vincamine is a commercially available medicinal agent used to enhance regional and systemic blood flow of the cardiovascular system [84–86] . Huigens et al.…”