Changes in mouse liver superoxide dismutase activity and lipid peroxidation during embryonic and postpartum development

Abstract

In inbred mice possessing 'high' and 'low' tissue superoxide dismutase (SOD) activity, it was observed that the difference in the SOD activities of the liver homogenates during development attains the maximum characteristic of the strain by about the 150th day. Subsequently, the SOD activity change displays a tendency in contrast with the age and the basic state. In the course of the development, a difference was also observed between the 2 mouse strains in the lipid peroxidation variation.

Oxidative stress and superoxide dismutase in development, aging and gene regulation

“…In fact, other antioxidants fail to stimulate differentiation, but some oxidants do (201,268). Indeed, increased free radical generation and accumulation of oxidation reaction products have repeatedly been observed during the differentiation and development of a wide variety of cells and organisms (205,243,(271)(272)(273)(274)(275)(276)(277). Itwas our observations inPhysarum (201,205) and Friend cell leukemia (268) that led us to postulate that an upsurge of oxidant production rather than increased antioxidant defenses were stimulatory to pathways involved in differentiation (36,192,201,205,268).…”