Changes in muscle fiber size and composition in response to heavy-resistance exercise

Mikesky, Alan E.; Giddings, C. J.; Matthews, William D.; Gonyea, W. J.

doi:10.1249/00005768-199109000-00008

Cited by 30 publications

(29 citation statements)

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“…E and F). It has already been demonstrated that muscle fiber size of CSAs does not account for all the observed increases in muscle mass, and other mechanisms, such as muscle fiber hyperplasia, may play a role in contributing to muscle mass increases .…”

Section: Discussionmentioning

confidence: 97%

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

Zheng

Hengevoß

Soukup

et al. 2017

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 97%

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

Zheng

Hengevoß

Soukup

et al. 2017

Molecular Nutrition Food Res

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“…Alternatively, the above findings could be explained by a change in the ratio of contractile to noncontractile muscle tissue. Against this notion, however, speaks the fact that the relative proportion of noncontractile tissue appears to remain unchanged in response to resistance training (Mikesky et al 1991;Wang et al 1993;Roman et al 1993).…”

Section: Relationships Between Measures Of Muscle Morphology and Archmentioning

confidence: 99%

A mechanism for increased contractile strength of human pennate muscle in response to strength training: changes in muscle architecture

Aagaard¹,

Andersen²,

Dyhre‐Poulsen³

et al. 2001

The Journal of Physiology

562

493

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In human pennate muscle, changes in anatomical cross‐sectional area (CSA) or volume caused by training or inactivity may not necessarily reflect the change in physiological CSA, and thereby in maximal contractile force, since a simultaneous change in muscle fibre pennation angle could also occur. Eleven male subjects undertook 14 weeks of heavy‐resistance strength training of the lower limb muscles. Before and after training anatomical CSA and volume of the human quadriceps femoris muscle were assessed by use of magnetic resonance imaging (MRI), muscle fibre pennation angle (θp) was measured in the vastus lateralis (VL) by use of ultrasonography, and muscle fibre CSA (CSAfibre) was obtained by needle biopsy sampling in VL. Anatomical muscle CSA and volume increased with training from 77.5 ± 3.0 to 85.0 ± 2.7 cm2 and 1676 ± 63 to 1841 ± 57 cm3, respectively (±s.e.m.). Furthermore, VL pennation angle increased from 8.0 ± 0.4 to 10.7 ± 0.6 deg and CSAfibre increased from 3754 ± 271 to 4238 ± 202 μm2. Isometric quadriceps strength increased from 282.6 ± 11.7 to 327.0 ± 12.4 N m. A positive relationship was observed between θp and quadriceps volume prior to training (r = 0.622). Multifactor regression analysis revealed a stronger relationship when θp and CSAfibre were combined (R= 0.728). Post‐training increases in CSAfibre were related to the increase in quadriceps volume (r = 0.749). Myosin heavy chain (MHC) isoform distribution (type I and II) remained unaltered with training. VL muscle fibre pennation angle was observed to increase in response to resistance training. This allowed single muscle fibre CSA and maximal contractile strength to increase more (+16 %) than anatomical muscle CSA and volume (+10 %). Collectively, the present data suggest that the morphology, architecture and contractile capacity of human pennate muscle are interrelated, in vivo. This interaction seems to include the specific adaptation responses evoked by intensive resistance training.

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“…These two factors are thought to account for the postnatal increase in total muscle mass [33]. This is also the case in "muscle fiber hypertrophy", such as that occurring after heavy resistance exercise [34][35][36][37][38][39] or in the compensatory enlarged muscle [40][41][42]. Therefore, satellite cells are considered "myoblast precursors" mainly working in the myofiber basal lamina cylinder.…”

Section: Primary Role Of Satellite Cellsmentioning

confidence: 99%

Plasticity and Physiological Role of Stem Cells Derived from Skeletal Muscle Interstitium: Contribution to Muscle Fiber Hyperplasia and Therapeutic Use

Tamaki

Uchiyama²,

Akatsuka³

2010

CPD

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Stem cells other than satellite cells that can give rise to primary myoblasts, which are able to form additional new fibers postnatally, are present in the interstitial spaces of skeletal muscle. These cells are sorted into CD34(+)/45(-) (Sk-34) and CD34(-)/45(-) (Sk-DN) cell fractions, and they are wholly (>99%) negative for Pax7 at initial isolation. Colony-forming units of these cells typically include non-adherent type myogenic cells, while satellite cells are known to be adherent in cell culture. In addition, both Pax7(-) and Pax7(+) cells are produced, depending on asymmetric cell division. A large number of myotubes are also formed in each colony, thus suggesting that putative Pax7(+) satellite cells also present in each colony. Interestingly, interstitial myogenic cells show basal lamina formation at early stages of myogenesis in response to various types of stimulation in compensatory enlarged muscle, a property that satellite cells do not possess in the parent fiber basal lamina cylinder. Basal lamina formation and production of satellite cells are essential before muscle fiber establishment in vivo. It is therefore likely that myogenic cells in skeletal muscle can be divided into two populations: 1) basal lamina-producing myogenic cells; and 2) basal lamina-non-producing myogenic cells. The latter population may be Pax7(+) satellite cells showing adherent capacity in cell culture, while the lamina-producing myogenic population derived from interstitial multipotent stem cells, which is predominant among Sk-34 and Sk-DN cells, plays a role in primary myoblast generation and shows non-adherent behavior in culture. Therefore, the physiological role of interstitial myogenic cells is as a source for new postnatal muscle fiber formation, and multinucleated muscle fibers (cells) are potentially formed clonally.

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Changes in muscle fiber size and composition in response to heavy-resistance exercise

Cited by 30 publications

References 0 publications

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

An isoflavone enriched diet increases skeletal muscle adaptation in response to physical activity in ovariectomized rats

A mechanism for increased contractile strength of human pennate muscle in response to strength training: changes in muscle architecture

Plasticity and Physiological Role of Stem Cells Derived from Skeletal Muscle Interstitium: Contribution to Muscle Fiber Hyperplasia and Therapeutic Use

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