Changes in nasal lavage fluid due to formaldehyde inhalation

Pazdrak, Konrad; Górski, Paweł; Krakowiak, Anna; Ruta, U

doi:10.1007/bf00381101

Cited by 82 publications

(38 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mucosal permeability might be increased in the upper airways, where inflammatory reactions have been demonstrated previously in guinea pigs (30). However, our study did not investigate the permeability of mucous membranes.…”

Section: Discussionmentioning

confidence: 77%

Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig

Riedel

Hasenauer

Barth

et al. 1996

Allergy

View full text Add to dashboard Cite

Formaldehyde (FA), a common indoor air pollutant, has been associated with increased prevalence rates of asthmatic symptoms among exposed individuals in epidemiologic surveys. We studied the influence of FA exposure on inhalative allergic sensitization in the guinea pig. Three groups of guinea pigs (n = 12 each) were exposed to clean air or two different FA concentrations (0.13 and 0.25 ppm) over 5 consecutive days. Exposure was followed by inhalation of 0.5% ovalbumin (OA) as sensitizing allergen. Three weeks later, specific bronchial provocation with OA was performed with body plethysmographic measurement of compressed air (CA). Furthermore, specific anti-OA-IgG 1 (reaginic) antibodies were determined in serum. In a further six animals, the respiratory tract was examined histologically for signs of inflammation directly after the end of FA or clean air exposure. In the group exposed to 0.25 ppm FA, 10/12 animals were found to be sensitized to OA (positive reaction on specific provocation) vs. 3/12 animals in the control group (P

show abstract

Section: Discussionmentioning

confidence: 77%

Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig

Riedel

Hasenauer

Barth

et al. 1996

Allergy

View full text Add to dashboard Cite

show abstract

“…They hypothesized that formaldehyde causes inflammation and the release of cytokines, which leads to the upregulation of inducible NO synthetase. This view was supported by another study that found intranasal exposure to 400 ppb formaldehyde in healthy subjects caused eosinophilia in the nasal epithelium (144).…”

Section: Formaldehyde Asthma and Atopy In Childrenmentioning

confidence: 76%

Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research.

Delfino

2002

Environ Health Perspect

269

152

View full text Add to dashboard Cite

Outdoor ambient air pollutant exposures in communities are relevant to the acute exacerbation and possibly the onset of asthma. However, the complexity of pollutant mixtures and etiologic heterogeneity of asthma has made it difficult to identify causal components in those mixtures. Occupational exposures associated with asthma may yield clues to causal components in ambient air pollution because such exposures are often identifiable as single-chemical agents (e.g., metal compounds). However, translating occupational to community exposure-response relationships is limited. Of the air toxics found to cause occupational asthma, only formaldehyde has been frequently investigated in epidemiologic studies of allergic respiratory responses to indoor air, where general consistency can be shown despite lower ambient exposures. The specific volatile organic compounds (VOCs) identified in association with occupational asthma are generally not the same as those in studies showing respiratory effects of VOC mixtures on nonoccupational adult and pediatric asthma. In addition, experimental evidence indicates that airborne polycyclic aromatic hydrocarbon (PAH) exposures linked to diesel exhaust particles (DEPs) have proinflammatory effects on airways, but there is insufficient supporting evidence from the occupational literature of effects of DEPs on asthma or lung function. In contrast, nonoccupational epidemiologic studies have frequently shown associations between allergic responses or asthma with exposures to ambient air pollutant mixtures with PAH components, including black smoke, high home or school traffic density (particularly truck traffic), and environmental tobacco smoke. Other particle-phase and gaseous co-pollutants are likely causal in these associations as well. Epidemiologic research on the relationship of both asthma onset and exacerbation to air pollution is needed to disentangle effects of air toxics from monitored criteria air pollutants such as particle mass. Community studies should focus on air toxics expected to have adverse respiratory effects based on biological mechanisms, particularly irritant and immunological pathways to asthma onset and exacerbation.

show abstract

“…In a number of clinical studies, generally mild to moderate eye, nose, and throat irritation was experienced by volunteers exposed for short periods to levels of FA ranging from 0.25 to 3.0 ppm. 26,27) Mucociliary clearance in the anterior portion of the nasal cavity was reduced following exposure to 0.25 ppm FA. 28) In addition, an increased incidence of micronucleated buccal or nasal mucosal cells has been reported in individuals occupationally exposed to FA.…”

Section: Discussionmentioning

confidence: 99%

The Release of Formaldehyde upon Decomposition of 2-Bromo-2-nitropropan-1, 3-diol (Bronopol)

Kajimura

Tagami

Yamamoto

et al. 2008

JOURNAL OF HEALTH SCIENCE

View full text Add to dashboard Cite

Changes in nasal lavage fluid due to formaldehyde inhalation

Cited by 82 publications

References 16 publications

Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig

Formaldehyde exposure enhances inhalative allergic sensitization in the guinea pig

Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research.

The Release of Formaldehyde upon Decomposition of 2-Bromo-2-nitropropan-1, 3-diol (Bronopol)

Contact Info

Product

Resources

About