Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge

Kirchner, Matthew K.; Althammer, Ferdinand; Donaldson, Kevin J.; Cox, Daniel N.; Stern, Javier E.

doi:10.1016/j.isci.2023.108243

iScience

2023

DOI: 10.1016/j.isci.2023.108243

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Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge

Matthew K. Kirchner,

Ferdinand Althammer,

Kevin J. Donaldson

et al.

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2024

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Cited by 2 publications

References 92 publications

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Neuropeptides: The Evergreen Jack‐of‐All‐Trades in Neuronal Circuit Development and Regulation

Hevesi,

Hökfelt,

Harkany

2024

BioEssays

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Neuropeptides are key modulators of adult neurocircuits, balancing their sensitivity to both excitation and inhibition, and fine‐tuning fast neurotransmitter action under physiological conditions. Here, we reason that transient increases in neuropeptide availability and action exist during brain development for synapse maturation, selection, and maintenance. We discuss fundamental concepts of neuropeptide signaling at G protein‐coupled receptors (GPCRs), with a particular focus on how signaling at neuropeptide GPCRs could underpin neuronal morphogenesis. We use galanin, a 29/30 amino acid‐long neuropeptide, as an example for its retrograde release from the dendrites of thalamic neurons to impact the selection and wiring of sensory afferents originating at the trigeminal nucleus through galanin receptor 1 (GalR1) engagement. Thus, we suggest novel roles for neuropeptides, expressed transiently or permanently during both pre‐ and postnatal neuronal circuit development, with potentially life‐long effects on circuit layout and ensuing behavioral operations.

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Neuropeptides: The Evergreen Jack‐of‐All‐Trades in Neuronal Circuit Development and Regulation

Hevesi,

Hökfelt,

Harkany

2024

BioEssays

View full text Add to dashboard Cite

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Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories

Parmaksiz,

Kim

2024

Neuroscientist

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Complex mechanisms govern the transport and action of oxytocin (Oxt), a neuropeptide and hormone that mediates diverse physiologic processes. While Oxt exerts site-specific and rapid effects in the brain via axonal and somatodendritic release, volume transmission via CSF and the neurovascular interface can act as an additional mechanism to distribute Oxt signals across distant brain regions on a slower timescale. This review focuses on modes of Oxt transport and action in the CNS, with particular emphasis on the roles of perivascular spaces, the blood-brain barrier (BBB), and circumventricular organs in coordinating the triadic interaction among circulating blood, CSF, and parenchyma. Perivascular spaces, critical conduits for CSF flow, play a pivotal role in Oxt diffusion and distribution within the CNS and reciprocally undergo Oxt-mediated structural and functional reconstruction. While the BBB modulates the movement of Oxt between systemic and cerebral circulation in a majority of brain regions, circumventricular organs without a functional BBB can allow for diffusion, monitoring, and feedback regulation of bloodborne peripheral signals such as Oxt. Recognition of these additional transport mechanisms provides enhanced insight into the systemic propagation and regulation of Oxt activity.

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Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge

Cited by 2 publications

References 92 publications

Neuropeptides: The Evergreen Jack‐of‐All‐Trades in Neuronal Circuit Development and Regulation

Neuropeptides: The Evergreen Jack‐of‐All‐Trades in Neuronal Circuit Development and Regulation

Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories

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