1992
DOI: 10.1165/ajrcmb/6.3.287
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Changes in Neutrophil Deformability following In Vitro Smoke Exposure: Mechanism and Protection

Abstract: We have previously demonstrated a reduction in the deformability of neutrophils, exposed to whole particulate cigarette smoke in vitro, by measuring their ability to filter through a micropore membrane with pore dimensions similar to those of the average pulmonary capillary segment. In this study, we exposed neutrophils to the vapor phase of cigarette smoke and investigated the mechanism of the reduction in neutrophil filterability. Although both stimulated neutrophils and smoke-exposed neutrophils demonstrate… Show more

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Cited by 68 publications
(27 citation statements)
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“…It has been suggested that since each puff of cigarette smoke contains > 10 16 oxidant molecules the effect of cigarette smoking is probably oxidantly mediated. This is confirmed by the fact that the decrease of neutrophil deformability is accompanied by the depletion of GSH (Drost et al, 1992). In addition oxidants affect it by altering cellular cytoskeleton through the polymerization of actin.…”
Section: Oxidative Stress Chaperones and Neutrophil Sequestration Inmentioning
confidence: 69%
“…It has been suggested that since each puff of cigarette smoke contains > 10 16 oxidant molecules the effect of cigarette smoking is probably oxidantly mediated. This is confirmed by the fact that the decrease of neutrophil deformability is accompanied by the depletion of GSH (Drost et al, 1992). In addition oxidants affect it by altering cellular cytoskeleton through the polymerization of actin.…”
Section: Oxidative Stress Chaperones and Neutrophil Sequestration Inmentioning
confidence: 69%
“…Oral NAC treatment likely decreases airway neutrophil count via multiple pathways. First, NAC can increase actin-dependent deformability (35), leading to reduced stasis in narrow lung capillaries (36). Second, NAC can inhibit the NF-B pathway (37), leading to decreased IL-8 production (as seen in a subset of patients), which can in turn limit neutrophil recruitment.…”
Section: Discussionmentioning
confidence: 99%
“…Neutrophils have enzymes that amplify the oxidative properties of HP2 which are important in host defense against parasites and pathogens. High levels of oxidative stress decrease neutrophil defonnability thus enhancing PMN sequestration in small blood vessels (36). In addition, circulating at release from PMN correlates with bronchial hyperactivity in capo patients (37); the increased number of neutrophils appear to make increased amounts of oxidants in the lung of capo patients (18).…”
Section: Discussionmentioning
confidence: 99%