Changes in NT-proBNP in Young Children With Congenital Heart Malformations

Butnariu, Angela; Iancu, Mihaela; Samaşcă, Gabriel; Chira, Manuel; Lupan, Iulia

doi:10.1309/lmao4uy90yjqwkkp

Cited by 5 publications

(7 citation statements)

References 20 publications

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“…We used a control group (16 children younger than 3 years old) in our previous studies [1] on NTproBNP. The value obtained to that control group was 43.5 fmol/mL.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of NT-proBNP in children with heart failure younger than 3 years old

Iacob

Butnariu

Leucuţa

et al. 2017

Romanian Journal of Internal Medicine

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Introduction. Heart failure (HF) is characterized by neuroendocrine activation. The cardiac natriuretic hormones, including atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), together with their related pro-peptides (proANP and proBNP) represent a group of peptide hormones produced by the heart. A normal NT-proBNP level has a high negative predictive value for heart failure. The use of NT-proBNP testing is helpful in diagnosing acute HF in the emergency care setting, allowing an early and optimal treatment. The purpose of this study is to assess the prognostic value of NT-proBNP in heart failure in children younger than 3 years old and to establish whether it correlates with the NYHA/Ross functional class and left ventricle systolic function.Methods. We enrolled 24 consecutive children with HF due to congenital heart diseases and dilated cardiomyopathy. The serum levels of NT-proBNP were measured, all patients underwent echocardiography and left ventricle ejection fraction was calculated.Results. The highest median value of NT-proBNP was recorded in patients with cyanotic heart diseases (248.0 fmol/mL), p = 0.610. NT-proBNP had a negative correlation with the ejection fraction of the left ventricle: Spearman's rank correlation coefficient was -0.165.Conclusions. NT-proBNP levels correlate with the severity of HF in infants and small children younger than 3 years old with heart failure due to congenital heart diseases and dilated cardiomyopathy.

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“…We used a control group (16 children younger than 3 years old) in our previous studies [1] on NTproBNP. The value obtained to that control group was 43.5 fmol/mL.…”

Section: Discussionmentioning

confidence: 99%

“…NT-proBNP is a ventricle distension and overload biomarker that can be used as early diagnostic tests in heart failure (HF) [1]. The concentrations of NT-proBNP are dependent on their synthesis, but also on their clearance and are highly influenced by the renal function.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of NT-proBNP in children with heart failure younger than 3 years old

Iacob

Butnariu

Leucuţa

et al. 2017

Romanian Journal of Internal Medicine

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Section: Brain Naturetic Peptide and Nt-probnpmentioning

confidence: 99%

“…This is likely because of the influence of acute cardiomyocyte injury causing an acute brain naturetic peptide/ NT-proBNP assay level rise which will recover and is an inaccurate assessment of potential ventricular failure in this period. 28,29 Role of NT-proBNP in single ventricle physiology Brain naturetic peptide/NT-proBNP is significantly elevated in patients with heart failure secondary to single ventricle physiology compared to children with similar anatomy who are not clinically in heart failure. [30][31][32] Studies have found that brain naturetic peptide/NT-proBNP baseline levels reduce with each subsequent stage of palliative surgery regardless of heart failure status.…”

Section: Natriuretic Peptidesmentioning

confidence: 99%

Paediatric heart failure – understanding the pathophysiology and the current role of cardiac biomarkers in clinical practice

et al. 2023

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Introduction: Paediatric heart failure is a common clinical syndrome that may be experienced by children with congenital heart disease (CHD) and/or cardiomyopathy. It is characterised by clinical signs/symptoms which reflect the underlying pathophysiology based on one of three main clinical states: Pulmonary over-circulation, pressure overload, and ventricular failure. Current diagnosis relies on clinical assessment and echocardiogram imaging as cardiac biomarkers has been predominantly scientific to date. This review provides a comprehensive overview of paediatric heart failure pathophysiology and considers the available evidence for cardiac biomarkers in this setting. Methods: A literature review was completed using MEDLINE ALL, EMBASE, and PubMed on 10th November, 2022. Search terms included biomarkers, heart failure, heart defects, congenital heart disease, fontan circulation, single ventricle circulation, cardiomyopathy, and child. This allowed the identification of individual cardiac biomarkers which are the focus of this review. These included NT-proBNP, MR-proANP, MR-proADM, troponin, sST2, galectin 3, and growth differentiation factor-15. Results: Paediatric studies have established reference ranges for NT-proBNP and troponin for children with structurally normal hearts. Of all the biomarkers reviewed, NT-proBNP appears to correlate most closely with symptoms of heart failure and ventricular dysfunction on echocardiogram. However, there remains limited longitudinal data for NT-proBNP, and no validated reference ranges for patients with CHD and/or cardiomyopathy. None of the other biomarkers reviewed were consistently superior to NT-proBNP. Conclusion: Further large paediatric studies of patients with heart failure are needed to validate NT-proBNP in CHD and to evaluate the role of novel biomarkers in specific types of CHD, e.g. single ventricle physiology.

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“…В ряде исследований, посвящённых изучению этого маркёра в детской кардиохирургии, анализировали его предоперационные значения [5,7,13,14]. В некоторых работах не отмечено статистически значимой связи между предоперационным содержанием NT-proBNP и длительностью ИВЛ и нахождения в отделении реанимации и интенсивной терапии [8].…”

Section: характеристика течения послеоперационного периода у обследованных пациентовunclassified

Prognostic value of N-terminal fragment of brain natriuretic peptide in pediatric cardiac surgery

et al. 2015

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Aim. To study the level of the N-terminal fragment of brain natriuretic peptide in children with congenital heart disease after surgical treatment and to determine its prognostic value in the postoperative period. Methods. A preoperative and postoperative examination of 113 children with congenital heart disease who were treated in the cardiac surgery department, was performed. Patients were allocated to four groups depending on the functional class of heart failure. Serum concentration of N-terminal brain natriuretic peptide fragment was determined by electrochemiluminescence before and one day after the surgery. Results. Postoperative levels of the N-terminal fragment of brain natriuretic peptide correlated with the duration of mechanical ventilation, the time that patient spends in the intensive care unit, the intensity of cardiotonic support. On the 1st day after the surgical intervention the concentration of this peptide was significantly increased in patients of the first, second and third group, by average of 7.8 times, due to the direct effect on the heart cells, surgical trauma, influence of cardioplegic solution, heart function alteration and heart failure associated with operative and post-operative period. In 24 patients of the fourth group, the N-terminal fragment of brain natriuretic peptide has significantly decreased on the first day after surgery. In 7 patients of the fourth group, the growth of the N-peptide level was reported, complicated postoperative period, sometimes with fatal outcome, took place in these cases. The level of this marker is associated with the frequency of postoperative complications, reoperations, and its threshold level for determining high-risk group for complications was 5400 pg/ml. Conclusion. The concentration of the N-terminal fragment of brain natriuretic peptide on day 1 after surgical intervention in patients with congenital heart disease can be used to predict the clinical course of postoperative period; the level above 5400 pg/ml is considered to be a risk factor for postoperative complications and reoperations.

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Changes in NT-proBNP in Young Children With Congenital Heart Malformations

Abstract: These results demonstrated significant changes in NT-proBNP concentrations before and after surgery to correct congenital heart malformations.

Cited by 5 publications

References 20 publications

Evaluation of NT-proBNP in children with heart failure younger than 3 years old

Evaluation of NT-proBNP in children with heart failure younger than 3 years old

Paediatric heart failure – understanding the pathophysiology and the current role of cardiac biomarkers in clinical practice

Prognostic value of N-terminal fragment of brain natriuretic peptide in pediatric cardiac surgery

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