Changes in Ocular Flora in Eyes Exposed to Ophthalmic Antibiotics

Sensibilidad antibiótica de bacterias obtenidas de queratitis e infecciones intraoculares en la Fundación Oftalmológica de Santander (FOSCAL), Floridablanca, Colombia

“…El 71 % de estas bacterias en los ojos tratados fue resistente a cinco o más antibióticos (25). Además, los autores encontraron que la aplicación repetida de macrólidos o fluoroquinolonas tópicas incrementó el porcentaje de S. epidermidis en la flora ocular (26).…”

Adherence to European Society for Cataract and Refractive Surgery Recommendations among Italian Cataract Surgeons: A Survey

“…28 However, it is controversial whether preoperative antibiotics or intracameral cefuroxime play a role in the routine prophylaxis of post-cataract endophthalmitis. [27][28][29][30][31][32][33][34] The majority of Italian cataract surgeons use topical fluoroquinolones in the perioperative period. In our survey, the use of perioperative antibiotics does not have a protective effect.…”

“…The overuse and repeated exposure to antibiotics may lead to the emergence of bacteria that do not respond readily to available treatments. Mounting evidencesuggests that ocular surface organisms are becoming more resistant to fluoroquinolones, [27][28][29][30][31][32] with up to 30% of cultured ocular isolates being resistant. In the era of "choosing wisely" and "antimicrobial stewardship" paradigms,…”

“…Mounting evidence suggests that ocular surface organisms are becoming more resistant to fluoroquinolones, with up to 30% of cultured ocular isolates being resistant. [28][29][30][31][32] Also, the efficacy and safety profile of intracameral cefuroxime during cataract surgery remain controversial since there are conflicting results in the literature about the additional protective effect of cefuroxime when added to the standard of care. 17,18,33,34 .…”

The role of antibiotics in the prevention of post-intravitreal anti-VEGF endophthalmitis: primum non nocere!

“…It was recently summarized and confirmed that repeated use of topical antibiotics on the conjunctival sac increases the rate of resistance of CNS to antibiotics. 5 For many years antibiotic use in PIAE, although lacking convincing scientific evidence of efficacy, was based on empiric rationale and believed to be not harmful. Nowadays, we are aware that using antibiotics without clear benefit might be harmful.…”