2007
DOI: 10.1016/j.heares.2007.02.008
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Changes in P2Y4 receptor expression in rat cochlear outer sulcus cells during development

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Cited by 15 publications
(9 citation statements)
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“…Pharmacological profiling of the ATP and UTP mediated short-circuit current in the outer sulcus is consistent with a P2Y 2 or P2Y 4 receptor-mediated increase in cation uptake in addition to the P2X 2 receptor path [47,48]. P2Y 14 receptor expression also occurs in these regions postnatally [49].…”
Section: Discussionmentioning
confidence: 54%
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“…Pharmacological profiling of the ATP and UTP mediated short-circuit current in the outer sulcus is consistent with a P2Y 2 or P2Y 4 receptor-mediated increase in cation uptake in addition to the P2X 2 receptor path [47,48]. P2Y 14 receptor expression also occurs in these regions postnatally [49].…”
Section: Discussionmentioning
confidence: 54%
“…The P2Y receptor-mediated cation return was prominent in the neonatal rat cochlea and downregulated to adult levels by the end of the second postnatal week [48]. This finding is consistent with our identification of the dynamics of P2Y 2 expression at this site, and may be reconciled with the P2Y 4 pharmacological designation of Lee et al [48] by considering that in the rat P2Y 2 and P2Y 4 receptors have comparable ATP and UTP agonist sensitivity [18]. In the inner sulcus and interdental cell region, where P2Y 4 and P2Y 6 expression was pronounced, this site is known to exhibit substantial ecto-NTPDase3 expression [50].…”
Section: Discussionmentioning
confidence: 95%
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“…The authors speculated that P2X7 receptors may be involved in signal transduction and modulation as well as in regulating cell death during development and in pathological conditions. It was reported that P2Y 4 and P2X2 receptors were coexpressed and contributed to the regulation of short circuit currents in rat cochlear neonatal outer sulcus cells [248]. They showed further that P2Y 4 receptor expression rapidly declined postnatally and reached near adult levels on postnatal day 14.…”
Section: Inner Earmentioning
confidence: 91%
“…Reissner's membrane also has P2X 2 receptors on the apical membrane, but these operate in parallel with Na + -selective epithelial sodium channels in the apical membrane (Lee and Marcus, 2003) rather than nonselective cation channels. Recent findings indicated that P2Y 4 receptors are expressed in developing outer sulcus cells, and then down-regulated in the adult (Lee et al, 2007).…”
Section: Apical (Endolymphatic Side) Receptorsmentioning
confidence: 99%