Changes in patients’ symptoms and gastric emptying after<i>Helicobacter pylori</i>treatment

Zhang, Chunyu; Geng, Chang-Hui; Yang, Zhiwei; Liu, Yanlin; Tong, Li-Quan; Gao, Ping; Gao, Yueqiu

doi:10.3748/wjg.v22.i18.4585

Cited by 21 publications

(21 citation statements)

References 50 publications

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“…However, this study found that the H. pylori infection rate was higher in populations experiencing dyspeptic symptoms in recent years than in the normal population, which is consistent with the findings of many studies (31,32). However, it remains controversial whether the eradication of H. pylori infection could improve the symptoms of functional dyspepsia (33,34). In the future, the correlation between different digestive symptoms and H. pylori infection, as well as the improvement of digestive symptoms post-H. pylori eradication, may be further studied to clarify the correlation between H. pylori infection and gastrointestinal symptoms.…”

Section: Relationship Between Helicobacter Pylori Infection and Persosupporting

confidence: 91%

Investigation of Helicobacter pylori Infection and Its Related Factors in the Tianjin Binhai Area, China

Zou

Xiao

Cheng

et al. 2019

Jundishapur J Microbiol

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Background: Helicobacter pylori is one of the most widely distributed and most common bacteria in the world. There is a discrepancy in the H. pylori infection rate among different regions and countries that may be due to many factors. Objectives: The study aimed to determine the current status of H. pylori infection in the Tianjin Binhai area, China, and evaluate the factors related to H. pylori infection. Methods: We recruited a sample of 2235 cases and conducted the 14 C or 13 C breath tests and questionnaire surveys. The factors affecting H. pylori infection were analyzed using the chi-square test and multiple logistic regression. Results: The overall H. pylori infection rate was 45.6%, with the highest rate among male and married population and the lowest rate in the 11-20-year-old group. Moreover, populations with a high degree of culture or income had lower infection rates (P < 0.05). Populations who were smoking, drinking, eating seafood, or had more salt intake had higher infection rates (P < 0.05). Furthermore, the infection rate was higher in the population who had hypertension (P = 0.001) or dyspeptic symptoms (P < 0.05) in the last year. It was revealed that taking a previous H. pylori examination and education level were negatively correlated with H. pylori infection, and marital status was an important influential factor for H. pylori infection. Conclusions: The rate of H. pylori infection was lower in the Tianjin Binhai area than in the whole country, which may be related to socioeconomic status and marital status. Furthermore, it is also probably related to gender and hypertension.

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Section: Relationship Between Helicobacter Pylori Infection and Persosupporting

confidence: 91%

Investigation of Helicobacter pylori Infection and Its Related Factors in the Tianjin Binhai Area, China

Zou

Xiao

Cheng

et al. 2019

Jundishapur J Microbiol

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“…In our study, the number of periganglionic inflammatory Analytical Cellular Pathology cells was significantly increased in H. pylori-positive patients compared to controls. Although this is an unusual finding, as gastritis is basically a mucosal disease, myenteric plexitis might be hypothesized as responsible for gastric dysmotility frequently described in H. pylori-induced gastritis [4,28]. The immunohistochemical analysis of the myenteric infiltrate revealed a significant component of CD3-immunoreactive T cells, in agreement with previous reports showing that in inflammatory neuropathies there is a predominant T cytotoxic activity directed against proteins expressed by enteric neurons [18,22].…”

Section: Inflammation Of Myenteric Plexussupporting

confidence: 90%

Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study

Sticlaru

Stăniceanu

Cioplea

et al. 2019

Analytical Cellular Pathology

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Chronic inflammation induced by Helicobacter pylori (H. pylori) infection plays a major role in development of gastric cancer. However, recent findings suggested that progression of inflammation and neoplastic transformation in H. pylori infection are more complex than previously believed and could involve different factors that modulate gastric microenvironment and influence host-pathogen interaction. Among these factors, gastric myenteric plexus and its potential adaptive changes in H. pylori infection received little attention. This study is aimed at identifying the impact of H. pylori-associated gastritis on number and morphology of nerve cells in the stomach. The distribution of density, inflammation, and programmed cell death in neurons was immunohistochemically assessed in full-thickness archival tissue samples obtained from 40 patients with H. pylori infection who underwent surgery for gastric cancer and were compared with findings on samples collected from 40 age- and sex-matched subjects without bacteria. Overall, significant differences were noted between H. pylori-positive and H. pylori-negative patients. The analysis of tissue specimens obtained from those with infection revealed higher density and larger surface of the myenteric nervous plexus, as well as a significant increase in the number of gastric neuronal cell bodies and glial cells compared to controls. A predominant CD3-immunoreactive T cell infiltrate confined to the myenteric plexus was observed in infected subjects. The presence of mature B lymphocytes, plasma cells, and eosinophils was also noted, but to a lesser extent, within the ganglia. Myenteric ganglionitis was associated with degeneration and neuronal loss. Our results represent the first histopathological evidence supporting the hypothesis that H. pylori-induced gastric inflammation may induce morphological changes in myenteric gastric ganglia. These findings could help gain understanding of some still unclear aspects of pathogenesis of H. pylori infection, with the possibility of having broader implications for gastric cancer progression.

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“…Salicru et al [29] showed low prevalence of H. pylori infection in patients with gastroparesis. Zhang et al reported H. pylori treatment improved gastric emptying in FD patients [30]. The relationship between H. pylori infection and gastric emptying is controversial.…”

Section: Discussionmentioning

confidence: 99%

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

Mori¹,

Suzuki

Matsuzaki³

et al. 2017

Digestion

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Background and Aim: Delayed gastric emptying is one of the reasons why functional dyspepsia (FD) occurs. The ¹³C-acetate breath test is widely used to evaluate gastric emptying. Nevertheless, the standard value of ¹³C-acetate breath test has not taken into account the gender difference of gastric emptying among healthy individuals. The main aim of this study was to readjust the standard value of ¹³C-acetate breath test in the light of gender differences. In addition, we clarified the prevalence and clinical characteristics of delayed gastric emptying in patients with FD using the modified standard values of ¹³C-acetate breath test. Methods: Fifty-two healthy individuals and 126 patients with patients with FD were enrolled. Gastric emptying was evaluated by the ¹³C-acetate breath test. The cut-off points of T_max for the diagnosis of delayed gastric emptying were determined on the basis of results from healthy individuals making a distinction of genders. Gastroesophageal reflux symptoms, dyspeptic symptoms, scores of anxiety and depression, age, body mass index (BMI), smoking and alcohol consumption were compared between the delayed gastric emptying group and the non-delayed gastric emptying group. Results: Since gastric emptying was delayed in healthy women compared with that in healthy men (T_max, 53.6 ± 19.3 vs. 42.7 ± 16.9 min, p = 0.04), we set the cut-off points of T_max at 60 min in men and at 75 min in women. In patients with FD, the prevalence of delayed gastric emptying was not different between men and women with the modified standard values of ¹³C-acetate breath test. (31.0 vs. 27.4%, p = 0.68). BMI was lower in the delayed gastric emptying group than in the non-delayed group among the male patients. Reflux symptoms were more severe in delayed gastric emptying group than in the non-delayed group among the female patients. Conclusion: The standard values of ¹³C-acetate breath test should be modified bearing the gender difference in mind. It provides us more appropriate information to understand the mechanisms of FD.

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Changes in patients’ symptoms and gastric emptying afterHelicobacter pyloritreatment

Abstract: FD patients have delayed gastric emptying. H. pylori infection treatment helps to improve symptoms of dyspepsia and is a reasonable choice for treatment in clinical practice.

Cited by 21 publications

References 50 publications

Investigation of Helicobacter pylori Infection and Its Related Factors in the Tianjin Binhai Area, China

Investigation of Helicobacter pylori Infection and Its Related Factors in the Tianjin Binhai Area, China

Dangerous Liaison: Helicobacter pylori, Ganglionitis, and Myenteric Gastric Neurons: A Histopathological Study

Gender Difference of Gastric Emptying in Healthy Volunteers and Patients with Functional Dyspepsia

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