Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery

Perdana, Olivia P.; Victor, Andi Arus; Oktarina, Virna Dwi; Prihartono, Joedo

doi:10.13181/mji.v24i4.1181

Cited by 2 publications

(4 citation statements)

References 13 publications

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“…The authors reported that there was increase in RNFL thickness in both the groups. 5 However, the mean change was significantly higher in glaucomatous eyes (p-value<0.001) as compared to non-glaucomatous eyes. The results were consistent with our study but their sample size was only 26 patients.…”

Section: Discussionmentioning

confidence: 81%

“…The sample size of 40 in each group was calculated by keeping the power of study equal to 80% and level of significance equal to 5%. 5 Patients were selected by non-probability, purposive sampling. Approval for the study was sought from the Institutional Review Board of hospital (Reference No: 00-209-20; dated 16 November 2020).…”

Section: Methodsmentioning

confidence: 99%

“…The sample size of 40 in each group was calculated by keeping the power of study equal to 80% and level of significance equal to 5%. 5 …”

Section: Methodsmentioning

confidence: 99%

“…One research compared RNFL thickness between glaucomatous and non-glaucomatous eyes. 5 However, the available research evidence was limited and there was no such published research in the local population, which necessitated the conduction of present study. As RNFL thickness is important marker in the diagnosis, prognosis and risk stratification of patients with glaucoma, so there is need to study the effect of cataract surgery in patients with co-existing glaucoma and to compare the results with non-glaucomatous eyes.…”

Section: Introductionmentioning

confidence: 97%

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Comparison of changes in retinal nerve fiber layer thickness and intraocular pressure between glaucoma and non-glaucoma patients after phacoemulsification

Shahid¹,

Saleem²,

Malik³

et al. 2022

Pak J Med Sci

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Objective: To compare the changes in Retinal Nerve Fiber Layer (RNFL) thickness and Intraocular Pressure (IOP) after phacoemulsification in patients with glaucoma versus without glaucoma. Methods: This was a quasi-experimental study, done at Lahore General Hospital, from January 2021 to December 2021. Patients with senile cataract were divided into two groups. One group included 40 patients, with ≥40 years of age and diagnosed with primary open angle glaucoma compared with a second group of 40 age-matched controls without glaucoma, undergoing phacoemulsification and Intraocular Lens Implantation (IOL). Goldman Applanation Tonometer (GAT) and Spectral Domain Optical Coherence Tomography (SD-OCT) were used to record IOP and RNFL thickness, before surgery, at one week and one month after surgery. The results were compared with baseline readings and also between the two groups. Results: A total of 80 patients were included in the study. Mean age was 60.3±7.9 years with male to female ratio of 1:1. Mean change in RNFL thickness in glaucomatous eyes group and non-glaucomatous Eyes group from pre-operative baseline was 11.33±4.30µm and 4.08±2.59µm respectively after one month (p-value<0.001). Difference of mean change in RNFL thickness from baseline was statistically significant between both groups (p< 0.001). Difference of mean change in IOP from baseline at four weeks was statistically significant in the individual groups but between both groups was statistically insignificant (p= 0.234) Conclusion: Phacoemulsification results in increase in RNFL thickness and decrease in IOP, which are good prognostic factors in control of glaucoma. However, a mean change of IOP of 1mmHg in glaucoma patient does not affect management of glaucoma. doi: https://doi.org/10.12669/pjms.39.1.6531 How to cite this: Shahid M, Saleem Z, Malik TG, Farqaleet M. Comparison of changes in retinal nerve fiber layer thickness and intraocular pressure between glaucoma and non-glaucoma patients after phacoemulsification. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6531 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

“…The sample size of 40 in each group was calculated by keeping the power of study equal to 80% and level of significance equal to 5%. 5 …”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Comparison of changes in retinal nerve fiber layer thickness and intraocular pressure between glaucoma and non-glaucoma patients after phacoemulsification

Shahid¹,

Saleem²,

Malik³

et al. 2022

Pak J Med Sci

View full text Add to dashboard Cite

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Comparison of Mean Retinal Nerve Fiber Layer Thickness on Optical Coherence Tomography (OCT) in Patients of Primary Open Angle Glaucoma (POAG) After Trabeculectomy vs Anti Glaucoma Medication

Latif,

Riaz,

Qamar

et al. 2023

PJHS

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Trabeculotomy is a surgical procedure in which a fistula is created between anterior chamber and sub-conjunctival space for drainage of aqueous. Glaucoma is a chronic disease. Objective: To compare the mean retinal nerve fibre layer thickness in patients of primary open angle glaucoma after trabeculectomy versus anti glaucoma medication. Methods: This Randomized controlled study done in Institute of Ophthalmology, Eye Unit III, KEMU, Mayo Hospital, Lahore from 10th Nov 2021 to 10th May 2022. Non-Probability Convenient Sampling technique used for sample size calculation. 60 patients were selected fulfilling the inclusion and exclusion criteria. They were divided into two groups of 30 patients each. Group A patient were given topical anti-glaucoma treatment while Group B patients underwent trabeculectomy. Pre and three months post anti-glaucoma medication/trabeculectomy, OCT test was done and thickness of retinal nerve fibre layer documented. Results: In group A, mean post-treatment RNFL thickness was 0.076 ± 0.052 microns after three months of topical treatment. In group B, mean post-treatment RNFL thickness was 0.080 ± 0.0048 microns three months after trabeculectomy. Conclusions: Trabeculectomy increases the mean retinal nerve fibre layer thickness more than anti-glaucoma medication when measured on OCT.

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Changes in peripapillary retinal nerve fiber layer thickness in chronic glaucoma and non-glaucoma patients after phacoemulsification cataract surgery

Cited by 2 publications

References 13 publications

Comparison of changes in retinal nerve fiber layer thickness and intraocular pressure between glaucoma and non-glaucoma patients after phacoemulsification

Comparison of changes in retinal nerve fiber layer thickness and intraocular pressure between glaucoma and non-glaucoma patients after phacoemulsification

Comparison of Mean Retinal Nerve Fiber Layer Thickness on Optical Coherence Tomography (OCT) in Patients of Primary Open Angle Glaucoma (POAG) After Trabeculectomy vs Anti Glaucoma Medication

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