Changes in Plasma Lipids and Lipoproteins in Overweight Men During Weight Loss Through Dieting As Compared With Exercise

Wood, Philip A.; Stefanick, Margia L.; Dreon, Darlene M.; Frey-Hewitt, B; Garay, S. C.; Williams, P.D.; Superko, Robert; Fortmann, Stephen P.; Albers, Jan; Vranizan, Karen; Ellsworth, Nancy M.; Terry, Richard; Haskell, W N

doi:10.1097/00008483-198904000-00009

Cited by 159 publications

(269 citation statements)

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“…In addition, it is also the preferred method in patients with comorbid diseases because it is rapidly performed, simple, and with a low morbidity rate [9]. SG strongly decreases the level of fundus secretion of appetizing ghrelin and improves and even leads to remission of type II diabetes mellitus [10]. SG becomes popular and also is one of the most frequently encountered surgical approaches, but its side effects and long time results are not well known.…”

Section: Discussionmentioning

confidence: 99%

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

et al. 2013

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Restriction of food intake leads to immunologic and histomorphological changes in rats demonstrated by Moriyama. This study is planned to show how sleeve gastrectomy restricts food intake and its effects on biochemical liver function, immunologic and hematologic laboratory parameters, and histomorphological changes in rats. We used sleeve gastrectomy model on seven young adult female rats and compared study group with sham and control groups. Food consumption of rats was measured. All rats were sacrificed on the 50th day, and blood and tissue samples were collected. There was a significant low food intake in sleeve gastrectomy group (p=0.013). No differences were observed on hematologic, biochemical, and immunologic laboratory parameters between groups. Toxicity parameters in liver samples such as cytoplasmic atrophy, single-cell hepatocellular necrosis, and necrotic eosinophilic cells were significantly high in sleeve gastrectomy group (p=0.005). Histomorphological examination of the spleen and kidneys revealed significant changes in sleeve gastrectomy and sham groups compared with controls (p=0.004 and p=0.018, respectively). Although sleeve gastrectomy does not lead to alteration in hematologic, biochemical, and immunologic laboratory parameters, it causes decreased food consumption, which results in toxicological histomorphological changes in rat liver as well as some changes in kidney and spleen samples.

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Section: Discussionmentioning

confidence: 99%

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

et al. 2013

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“…Sixteen RCTs [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] were identified that had compared weight loss in groups assigned physical activity alone with that in groups assigned no intervention. A summary of the findings of these RCTs is included in Table 1.…”

Section: Physical Activity Alonementioning

confidence: 99%

“…Of the 16 RCTs, 11 found statistically significant improvements in weight loss with exercise compared with controls. 2,3,[5][6][7][9][10][11]13,16,17 The magnitude of the differences in weight outcomes between groups in these studies was small. Weight loss in the exercise group ranged from 0.1 kg to 5.2 kg, with most studies showing weight loss of only 1-3 kg.…”

Section: Physical Activity Alonementioning

confidence: 99%

The role of physical activity in producing and maintaining weight loss

2007

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SummaryThe majority of randomized, controlled trials (RCTs) show only modest weight loss with exercise intervention alone, and slight increases in weight loss when exercise intervention is added to dietary restriction. In most RCTs, the energy deficit produced by the prescribed exercise is far smaller than that usually produced by dietary restriction. In prospective studies that prescribed high levels of exercise, enrolled individuals achieved substantially greater weight losscomparable to that obtained after similar energy deficits were produced by caloric restriction. High levels of exercise might, however, be difficult for overweight or obese adults to achieve and sustain. RCTs examining exercise and its effect on weight-loss maintenance demonstrated mixed results; however, weight maintenance interventions were usually of limited duration and long-term adherence to exercise was problematic. Epidemiologic, cross-sectional, and prospective correlation studies suggest an essential role for physical activity in weight-loss maintenance, and post hoc analysis of prospective trials shows a clear dose-response relationship between physical activity and weight maintenance. This article reviews the role of physical activity in producing and maintaining weight loss. We focus on prospective, RCTs lasting at least 4 months; however, other prospective trials, meta-analyses and large systematic reviews are included. Limitations in the current body of literature are discussed.

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“…Studies included-Of the 3750 citations reviewed, 21 met our inclusion criteria [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]39,40]. However, we were unable to include two studies because of the inability to retrieve necessary data for HDL 2 -C [39,40].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…However, the results of previous randomized controlled trials dealing with the effects of aerobic exercise on HDL 2 -C have led to less than overwhelming results [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], with only 30% of HDL 2 -C outcomes reported as statistically significant. While this may lead one to question the utility of aerobic exercise for increasing HDL 2 -C in adults, such a conclusion would be based on the vote-counting approach (percentage of statistically significant results), a procedure that has been shown to be less accurate than the more quantitative meta-analytic approach [23].…”

Section: Introductionmentioning

confidence: 99%

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

Kelley

2006

Atherosclerosis

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Purpose-Use the meta-analytic approach to examine the effects of aerobic exercise on highdensity lipoprotein two cholesterol (HDL 2 -C) in adults.Study sources-(1) Computerized literature searches; (2) cross-referencing from retrieved articles; (3) hand-searching; and (4) expert review of our reference list.Study selection-(1) Randomized controlled trials; (2) aerobic exercise ≥8 weeks; (3) adults ≥18 years of age; (4) studies published in journal, dissertation, or master's thesis format; (5) studies published in the English-language between January 1, 1955 and January 1, 2003; and (6) assessment of HDL 2 -C in the fasting state.Data abstraction-All coding conducted by both authors, independent of each other. Discrepancies were resolved by consensus.Results-Nineteen randomized controlled trials representing 20 HDL 2 -C outcomes from 984 males and females (516 exercise, 468 control) were pooled for analysis. Using random-effects modeling and bootstrap confidence intervals (BCI), a statistically significant increase of approximately 11% was observed for HDL 2 -C (X̄ ± S.E.M., 2.6±0.9 mg/dl, 95% BCI, 1.0-4.4 mg/dl). With each study deleted from the model once, results remained statistically significant. Increases in HDL 2 -C were independent of decreases in body weight, body mass index (kg/m 2 ), and percent body fat.Conclusion-Aerobic exercise increases HDL 2 -C in adults.

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Changes in Plasma Lipids and Lipoproteins in Overweight Men During Weight Loss Through Dieting As Compared With Exercise

Cited by 159 publications

References 0 publications

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

Hematological, Biochemical, and Immunological Laboratory and Histomorphological Effects of Sleeve Gastrectomy on Female Rats

The role of physical activity in producing and maintaining weight loss

Aerobic exercise and HDL2-C: A meta-analysis of randomized controlled trials

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