Changes in projections to the inferior colliculus following early hearing loss in rats

Hatano, Miyako; Ito, Makoto; Yoshizaki, Tomokazu; Kelly, Jack B.

doi:10.1016/j.heares.2012.03.011

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…Amikacin caused partial loss of SGNs over the entire cochlea, with the extent being largest in the basal and smallest in the apical turn. Thus, our results agreed with existing findings regarding effects of aminoglycosides on the auditory sensory organ 17–20,36,37 . Such changes could severally affect neurophysiological responses to sounds 37,38 .…”

Section: Discussionsupporting

confidence: 93%

“…Area-dependent changes of LFP in the IC in response to intracochlear stimulation were likely due to factors other than shrinkage of the structure. Although systemic applications of amikacin are known to cause shrinkage of the cochlear nuclei 37,40 , they did not cause a similar change in the IC.…”

Section: Discussionmentioning

confidence: 80%

“…Previous studies have indicated that electrical currents applied to the cochlea can stimulate not only SGNs (i.e., electroneural stimulation) but also hair cells (i.e., electrophonic stimulation) 45,46 . Furthermore, the reduction of LFPs could have been dependent on central plastic changes such as alteration of synaptic density in the auditory midbrain 47 and reduction in the number of neurons projecting from the cochlear nucleus to the IC 37 .…”

Section: Discussionmentioning

confidence: 99%

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Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage

Hatano

Kelly

Zhang

2019

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To understand brain changes caused by auditory sensory deprivation, we recorded local-field potentials in the inferior colliculus of young adult rats with neonatal cochlear damage produced by systemic injections of amikacin. The responses were elicited by electrical stimulation of the entire cochlea and recorded at various locations along a dorsolateral-ventromedial axis of the inferior colliculus. We found that hair cells were completely destroyed and spiral ganglion neurons were severely damaged in the basal cochleae of amikacin-treated animals. Hair cells as well as spiral ganglion neurons were damaged also in the middle and apical areas of the cochlea, with the damage being greater in the middle than the apical area. Amplitudes of local-field potentials were reduced in the ventromedial inferior colliculus, but enhanced in the dorsolateral inferior colliculus. Latencies of responses were increased over the entire structure. The enhancement of responses in the dorsolateral inferior colliculus was in contrast with the damage of hair cells and spiral ganglion cells in the apical part of the cochlea. This contrast along with the overall increase of latencies suggests that early cochlear damage can alter neural mechanisms within the inferior colliculus and/or the inputs to this midbrain structure.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage

Hatano

Kelly

Zhang

2019

Sci Rep

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“…In addition, these authors described synaptic contacts on small unidentified cells. Multipolar cells in CN are a highly diverse group of cells which are thought to have different projection patterns (Adams, 1979;Adams & Warr, 1976;Benson & Potashner, 1990;Beyerl, 1978;Cant & Gaston, 1982;Coleman & Clerici, 1987;Fredrich, Reisch, & Illing, 2009;Hatano, Ito, Yoshizaki, & Kelly, 2012;Oliver, 1987;Osen, 1972;Schofield & Cant, 1996a;Shore et al, 1991Shore et al, , 1992Wenthold, 1987). Fujino and Oertel (2001) suggested that collateral branches of MOC axons in the VCN make excitatory cholinergic connections with a particular subgroup of multipolar cells, T-stellate cells, rather than D-stellate cells.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Targets of olivocochlear collaterals in cochlear nucleus of rat and guinea pig

Baashar

Robertson

Yates

et al. 2019

J of Comparative Neurology

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Descending auditory pathways can modify afferent auditory input en route to cortex. One component of these pathways is the olivocochlear system which originates in brainstem and terminates in cochlea. Medial olivocochlear (MOC) neurons also project collaterals to cochlear nucleus and make synaptic contacts with dendrites of multipolar neurons. Two broadly distinct populations of multipolar cells exist: T‐stellate and D‐stellate neurons, thought to project to inferior colliculus and contralateral cochlear nucleus, respectively. It is unclear which of these neurons receive direct MOC collateral input due to conflicting results between in vivo and in vitro studies. This study used anatomical techniques to identify which multipolar cell population receives synaptic innervation from MOC collaterals. The retrograde tracer Fluorogold was injected into inferior colliculus or cochlear nucleus to label T‐stellate and D‐stellate neurons, respectively. Axonal branches of MOC neurons were labeled by biocytin injections at the floor of the fourth ventricle. Fluorogold injections resulted in labeled cochlear nucleus multipolar neurons. Biocytin abundantly labeled MOC collaterals which entered cochlear nucleus. Microscopic analysis revealed that MOC collaterals made some putative synaptic contacts with the retrogradely labeled neurons but many more putative contacts were observed on unidentified neural targets. This suggest that both T‐ and D‐stellate neurons receive synaptic innervation from the MOC collaterals on their somata and proximal dendrites. The prevalence of these contacts cannot be stated with certainty because of technical limitations, but the possibility exists that the collaterals may also make contacts with neurons not projecting to inferior colliculus or the contralateral cochlear nucleus.

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An Integrative Model of Subcortical Auditory Plasticity

2013

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In direct conflict with the concept of auditory brainstem nuclei as passive relay stations for behaviorally-relevant signals, recent studies have demonstrated plasticity of the auditory signal in the brainstem. In this paper we provide an overview of the forms of plasticity evidenced in subcortical auditory regions. We posit an integrative model of auditory plasticity, which argues for a continuous, online modulation of bottom-up signals via corticofugal pathways, based on an algorithm that anticipates and updates incoming stimulus regularities. We discuss the negative implications of plasticity in clinical dysfunction and propose novel methods of eliciting brainstem responses that could specify the biological nature of auditory processing deficits.

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Changes in projections to the inferior colliculus following early hearing loss in rats

Cited by 6 publications

References 29 publications

Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage

Area-dependent change of response in the rat’s inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage

Targets of olivocochlear collaterals in cochlear nucleus of rat and guinea pig

An Integrative Model of Subcortical Auditory Plasticity

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