2022
DOI: 10.1167/tvst.11.8.2
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Changes in Rat Scleral Collagen Structure Induced by UVA–Riboflavin Crosslinking at Various Tissue Depths in Whole Globe Versus Scleral Patch

Abstract: Purpose To investigate structural changes in scleral collagen fibers at various tissue depths before and after photosensitized crosslinking (CXL) both isolated scleral patch versus whole globe using second-harmonic generation (SHG) imaging. Methods Scleral tissues were harvested from Sprague–Dawley rats and separated into three groups: untreated sclera (control), full-thickness scleral patch for CXL (Free Scleral CXL group), and sclera in intact globe for CXL (Globe CXL… Show more

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