Changes in risk factors and Tumor Node Metastasis stage of sporadic medullary thyroid carcinoma over 41 years, before and after the routine measurements of serum calcitonin

Postoperative biochemical remission of serum calcitonin is the best predictive factor for recurrence‐free survival of medullary thyroid cancer: a large‐scale retrospective analysis over 30 years

“…Similar to secular trends of DTC, the mean age of patients with MTC increased with time, and the pathological features of initial presentations became less aggressive. These results suggested the effect of early detection of MTC in recent periods, and it is consistent with previous reports . Alevizaki et al .…”

Medullary thyroid carcinoma: the influence of policy changing in clinical characteristics and disease progression

“…This illustrates the importance of applying scientific knowledge in patient care, which may have significant effects on the outcome of malignant disease. Similar results have been reported in other studies (4,10,19). In an older study, Modigliani et al (5) reported biochemical cure in 37.6% in sporadic cases, which is lower compared with the remission rate in our groups before 2001 (41.5%) and after 2001 (61.2%).…”

“…When familial cases were excluded, there was still a tendency toward the same direction. Similar findings have been reported from other centers, indicating the common developments in investigation tools and management in such patients (19). Modigliani et al (5), in a study performed before 1996, reported a micro-MTC incidence of w32%, which is higher compared with our group diagnosed before 2001 (27.8%) but lower compared with that diagnosed after 2001 (46.1%).…”

“…However, a few studies have been performed in the last 40 years that have compared the clinical and biochemical characteristics of the disease during different chronological periods in the same center (16,19). We did not find significant differences in the stage of disease at diagnosis between the two groups.…”

Screening for medullary carcinoma of the thyroid

“…MTC has a potential for aggressive behaviour independent of size. Delayed diagnosis and inadequate initial treatment influence the prognosis.…”