Changes in scopoletin concentration in cassava chips from four varieties during storage

Gnonlonfin, Benoit; Gbaguidi, Fernand; Gbénou, Joachim; Sanni, Ambaliou; Brimer, Leon

doi:10.1002/jsfa.4465

Cited by 16 publications

(22 citation statements)

References 11 publications

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“…2). As seen earlier (Gnonlonfin et al . 2011), significant scopoletin levels were found in this cassava variety (BEN 86052) at harvest and after sun drying for 6 days as chips with a mean level of 4.9 mg/kg dry weight and 242.5 mg/kg dry weight, respectively.…”

Section: Resultssupporting

confidence: 83%

“…Manihot esculenta Crantz stalk from the variety named BEN 86052 were grown at the North Agricultural Research Center located at Ina, Institute of Agricultural Research, Ministry of Agriculture, Livestock and Fishery, Benin and the root tubers harvested after 6 months. Root tubers of this variety known to produce high amount of scopoletin during postharvest deterioration (Gnonlonfin et al . 2011) were used.…”

Section: Methodsmentioning

confidence: 99%

“…The compound analysis was with autosampler HPLC (Waters, model L‐2200, Hitachi High Technologies America Inc., Pleasanton, CA) using a modified method of Buschmann et al . (2000) as described by Gnonlonfin et al . (2011).…”

Section: Methodsmentioning

confidence: 99%

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Scopoletin in Cassava Products as an Inhibitor of Aflatoxin Production

Gnonlonfin

Adjovi²,

Gbaguidi

et al. 2011

Journal of Food Safety

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The scopoletin level in a cassava variety from Benin, BEN 86052, and the compounds effect on the growth of an Aspergillus flavus isolate from cassava chips were investigated. The influence on the biosynthesis of aflatoxins was also investigated. Scopoletin was quantified using high performance liquid chromatography. An in vitro test was used to evaluate the inhibitory effects of cassava flour extracts and pure scopoletin on growth and biosynthesis. The A. flavus isolate was genetically characterized to be an aflatoxin producer using polymerase chain reaction. Scopoletin was found in roots and chips with a level ranging from 4.9 to 242.5 mg/kg dry weight. Scopoletin induction was noticed after a peeling and drying process (6 days). Aflatoxin production by a strain of A. flavus holding the cluster Nor1, Omt1 and OmtB responsible for aflatoxin biosynthesis was inhibited by scopoletin and cassava flour at lower concentrations (0.024 mM). Scopoletin could be used on other commodities susceptible to mycotoxin contamination. PRACTICAL APPLICATIONS Scopoletin accumulated in cassava variety used for chips production. Scopoletin inhibited the production of aflatoxin by toxigenic Aspergillus flavus. The use of this compound on other crops susceptible to fungi infection and aflatoxin contamination could be investigated to reduce food spoilage and mycotoxin contamination.

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Section: Resultssupporting

confidence: 83%

Section: Methodsmentioning

confidence: 99%

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Scopoletin in Cassava Products as an Inhibitor of Aflatoxin Production

Gnonlonfin

Adjovi²,

Gbaguidi

et al. 2011

Journal of Food Safety

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“…Scopoletin, 7-hydroxy-6-methoxychromen-2-one, is a naturally-derived coumarin and a phytoalexin. It has been isolated from many different plant families including Gramineae, Liliaceae, Musaceae, Compositae, Convolvulaceae, and Loasaceae [5,6]. Scopoletin has been reported to inhibit acetylcholinesterase [7], to have antioxidant properties [8] and anti-inflammatory effects [9], and to reduce insulin resistance [10]; however, the effects of scopoletin on melanin synthesis have yet to be reported.…”

Section: Introductionmentioning

confidence: 99%

Scopoletin fromCirsium setidensIncreases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells

Ahn

Hur

Kim

et al. 2014

Korean J Physiol Pharmacol

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In this study, we isolated scopoletin from Cirsium setidens Nakai (Compositae) and tested its effects on melanogenesis. Scopoletin was not toxic to cells at concentrations less than 50 µM and increased melanin synthesis in a dose-dependent manner. As melanin synthesis increased, scopoletin stimulated the total tyrosinase activity, the rate-limiting enzyme of melanogenesis. In a cell-free system, however, scopoletin did not increase tyrosinase activity, indicating that scopoletin is not a direct activator of tyrosinase. Furthermore, Western blot analysis showed that scopoletin stimulated the production of microphthalmia-associated transcription factor (MITF) and tyrosinase expression via cAMP response element-binding protein (CREB) phosphorylation in a dose-dependent manner. Based on these results, preclinical and clinical studies are needed to assess the use of scopoletin for the treatment of vitiligo.

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“…The mean content in fresh roots from four varieties varied between 4.1 to 11.1 mg/kg, while the content after 6 days rose to 242 mg/kg for the cultivar showing the highest increase (Gnonlonfin et al, 2011).…”

Section: Unit Processes and Their Influence On The Composition Of Casmentioning

confidence: 89%

Cassava Production and Processing and Impact on Biological Compounds

Brimer

2015

Processing and Impact on Active Components in Food

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Changes in scopoletin concentration in cassava chips from four varieties during storage

Abstract: Strong accumulation of scopoletin in cassava roots used for chip production in Benin is followed by a decrease in its concentration.

Cited by 16 publications

References 11 publications

Scopoletin in Cassava Products as an Inhibitor of Aflatoxin Production

Scopoletin in Cassava Products as an Inhibitor of Aflatoxin Production

Scopoletin fromCirsium setidensIncreases Melanin Synthesis via CREB Phosphorylation in B16F10 Cells

Cassava Production and Processing and Impact on Biological Compounds

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