Changes in seroprevalence to four herpesviruses over 30 years in Swedish children aged 9–12 years

Svahn, Anita; Berggren, Johan; Parke, Anna; Storsæter, Jann; Thorstensson, Rigmor; Linde, Annika

doi:10.1016/j.jcv.2006.07.012

Cited by 42 publications

(34 citation statements)

References 30 publications

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“…There have been reports from several countries about changing HCMV seroprevalences. While a group in Sweden discovered a signiWcant rise of HCMV prevalence over 30 years, reports from Spain state a decline in prevalence between 1993 and 1999 [31,34]. Furthermore, a study from Japan describes a decline of HCMV-IgG seropositive rates in pregnant woman from 87.4% in 1985 to 75.2% in 1996/1997 [32].…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Human Cytomegalovirus (HCMV) in an urban region of Germany: what has changed?

Lübeck

Doerr

Rabenau

2009

Med Microbiol Immunol

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Since the dynamics of transmission of human cytomegalovirus (HCMV) have not been clarified yet, we assessed a possible change in HCMV seroprevalence in Frankfurt am Main, Germany during the past twenty years and tried to detect variables with an impact on epidemiology. Between 1/1/1988 and 10/15/2008, a total of 54443 serum samples were collected for routine diagnostics and analyzed using Enzygnost Anti HCMV-IgG enzyme immunoassay (Siemens/Dade Behring, Marburg, Germany). Two decades, 1/1/1988-12/31/1997 and 1/1/1998-10/15/2008, and several groups (type of health insurance, gender, age, HIV-status) were evaluated to assess changes in seroprevalence. Regarding both decades, the overall age-adjusted prevalence of HIV-negative patients dropped from 63.70% (confidence interval (CI) 95% 63.15-64.25) to 57.25% (CI 95% 56.57-57.93; P < 0.0001). Private health insurance (PHI) patients showed significant lower HCMV seroprevalences than members of obligatory health insurances (OHI) in both decades (1988-1997: PHI = 55.79%, OHI = 64.27%; P < 0.0001; 1998-1908: PHI = 47.02%, OHI = 58.74%; P < 0.0001). Furthermore, comparing the two decades, there was generally a gender-specific statistically significant decrease in HCMV seroprevalence for males (63.54-55.54%) and females (63.83-58.73%) as well as for members of PHI and OHI (PHI males: 57.59% to 47.19%, PHI females 54.10-46.80%; OHI males: 64.00-57.06%, OHI females 64.50-60.11%). Also, while female HIV-positive patients showed significant difference in HCMV seroprevalence between the two decades (83.17 and 87.80%, P = 0.023), there was no significant difference in male patients with HIV (88.76 and 87.32% in the first and second decade, respectively (P = 0.196). The cumulative HCMV prevalence of all HIV-negative patients tested in the past 20 years demonstrates a biphasic, age-related rise of HCMV seroprevalence throughout all age-groups. The seroprevalence of HCMV has declined between 1988-1997 and 1998-2008 in Frankfurt am Main, Germany. The decline varied between different age-groups. HCMV prevalence correlates with the type of health insurance, gender, age, and HIV-status.

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Section: Discussionmentioning

confidence: 99%

Epidemiology of Human Cytomegalovirus (HCMV) in an urban region of Germany: what has changed?

Lübeck

Doerr

Rabenau

2009

Med Microbiol Immunol

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“…34 Furthermore, CMV seroprevalence changes across time have been reported within other countries. 35,36 This study had several strengths. First, we used a populationbased sample and our estimates for demographic and child care center measures were nationally representative.…”

Section: Discussionmentioning

confidence: 99%

Cytomegalovirus seroprevalence and childhood sources of infection: A population-based study among pre-adolescents in the United States

Staras

Flanders

Dollard

et al. 2008

Journal of Clinical Virology

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“…VZV vaccination could change chickenpox epidemiology and might influence the incidence of CNS complications (Rentier, 2004;Svahn et al, 2006). However, chickenpox vaccine is scarcely used in Tuscany.…”

Section: Discussionmentioning

confidence: 99%

An increasing incidence of chickenpox central nervous system complications in children: What's happening in Tuscany?

Frenos

Galli

Chiappini

et al. 2007

Journal of Clinical Virology

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Changes in seroprevalence to four herpesviruses over 30 years in Swedish children aged 9–12 years

Cited by 42 publications

References 30 publications

Epidemiology of Human Cytomegalovirus (HCMV) in an urban region of Germany: what has changed?

Epidemiology of Human Cytomegalovirus (HCMV) in an urban region of Germany: what has changed?

Cytomegalovirus seroprevalence and childhood sources of infection: A population-based study among pre-adolescents in the United States

An increasing incidence of chickenpox central nervous system complications in children: What's happening in Tuscany?

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