Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Sillence, M. N.; Etherton, Terry D.

doi:10.1677/joe.0.1230113

Cited by 10 publications

(10 citation statements)

References 19 publications

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“…It was assumed that the low body weight gains in these two groups were due to the irritation and discomfort caused by injections. These observed decreases in body weight in rats were consistent with the results of Silence's study [20] which noted decreases in weight gain in control injected rats.…”

Section: Growth Effect Of Rhghsupporting

confidence: 91%

“…Rats have been utilized as a model to study the physiologic and growth effects of growth hormone [2,[20][21][22][23][24][25][26][27][28][29]. It has been reported that rhGH injections given in the morning to the rats show a better growth effect than injections given in the evening [20].…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that rhGH injections given in the morning to the rats show a better growth effect than injections given in the evening [20]. Also, pulsatile administration is more effective than continuous administration [21], and rhGH absorption after subcutaneous injection is better than intramuscular injection [22].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats

Lin

Lee²,

Ravis³

2013

Clin Exp Pharmacol

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Objectives: To investigate the pharmacokinetics of Carbamazepine (CBZ) in rats during growth hormone treatment.Methods: Recombinant Human Growth Hormone (rhGH) was injected subcutaneously at a daily dose of 0.1 mg/ kg, 2 mg/kg, or phosphate buffered saline (control) for 5 days in male Sprague-Dawley rats. On day 6, a dose of 25 mg/kg of CBZ was injected intravenously via a jugular vein cannula into the rat. Growth rate were compared between treatment groups. The pharmacokinetics of CBZ was determined from its concentrations in rats' blood and urinary samples.Results: Over the 5-day treatment period, growth rate were greater than control for the 2 mg/kg rhGH dosed group. The volume of distribution (V ss ) was significantly (p<0.05) decreased in the high dosed rhGH rats compared to the control group. Total body clearance (CL) in the 2 mg/kg rhGH group was also significantly (p<0.05) decreased compared with the control group (0.497 ± 0.076 L/hr/kg vs 0.685 ± 0.109 L/hr/kg). Urinary data showed that renal and metabolic clearances were both significantly (p<0.05) decreased in the 2 mg/kg rhGH group. Conclusions:A dose dependent effect of rhGH was observed on growth rates and CBZ pharmacokinetics in rats. After 5 days rhGH treatment, the volume of distribution of CBZ was significantly changed in the 2 mg/kg/day rhGH treated groups. In the 2 mg rhGH/kg treated rats, both renal and metabolic clearance of CBZ were also significantly decreased compared with the control group. Similar decreases in volume of distribution and both clearances may suggest the interaction may involve increased CBZ plasma protein binding during rhGH treatment in rats.

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Section: Growth Effect Of Rhghsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats

Lin

Lee²,

Ravis³

2013

Clin Exp Pharmacol

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“…observations]. These observations, along with the in creased abundance of corticotrophs in one of these lines [ 1] and the reports of increased ACTH levels in GH-treated rats [2] and of direct effects of GH and insulin-like growth factor-1 (IG F-1) on the adrenal cortex [3,4], raised a possibility that ectopic ex pression of heterologous GH genes may lead to stimulation of adrenocortical activity. To examine this possibility, we have measured plasma corticosterone levels and adrenal corticoste rone content under basal conditions and after standardized stressful stimulus.…”

mentioning

confidence: 96%

Elevated Corticosterone Levels in Transgenic Mice Expressing Human or Bovine Growth Hormone Genes

Cecim

Ghosh²,

Esquifino³

et al. 1991

Neuroendocrinology

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Ectopic expression of human or bovine growth hormone (GH) genes in 6 lines of transgenic mice was associated with a significant increase in plasma corticosterone levels. Elevated corticosterone levels were detected in both sexes under basal conditions and after ether stress. The adrenal activity of 3β-hydroxysteroid dehydrogenase was measured in two of these lines and was found to be significantly increased in transgenic animals. Plasma corticosterone levels in transgenic mice did not correlate with known differences between the various lines in male and female fertility or in the life span.

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“…GH may promote growth both directly and indirectly through its stimulation of IGF-I synthesis (Gargosky et al 1991). The anabolic and re-partitioning effects of both GH and IGF-I have been demonstrated in non-pregnant rats (Philipps et al 1988, Sillence & Etherton 1989. Several groups have studied the effects of administering IGF-I or GH to pregnant rats on the growth of their fetuses and have obtained conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Administration of growth hormone or IGF-I to pregnant rats on a reduced diet throughout pregnancy does not prevent fetal intrauterine growth retardation and elevated blood pressure in adult offspring

Woodall¹,

Breier²,

Johnston³

et al. 1999

Journal of Endocrinology

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Increasing evidence from human epidemiological studies suggests that poor growth before birth is associated with postnatal growth retardation and the development of cardiovascular disease in adulthood. We have shown previously that nutritional deprivation in the pregnant rat leads to intrauterine growth retardation (IUGR), postnatal growth failure, changes in the endocrine parameters of the somatotrophic axis, and to increased blood pressure in later life. In the present study, we investigated whether administration of insulin-like growth factor-I (IGF-I) or bovine growth hormone (GH) during pregnancy could prevent IUGR and/or alter long-term outcome. Dams from day 1 of pregnancy throughout gestation received a diet of ad libitum available food or a restricted dietary intake of 30% of ad libitum fed dams. From day 10 of gestation, dams were treated for 10 days with three times daily subcutaneous injections of saline (100 µl), IGF-I (2 µg/g body weight) or GH (2 µg/g body weight). Maternal weight gain was significantly increased (P<0·001) in ad libitum fed dams treated with GH, (98·9 4·73 g) compared with the IGF-I (80·5 2·17 g) and saline-treated (70·7 2·65 g) groups. There was a small increase in maternal weight gain (P<0·06) in 30% ad libitum fed dams following GH (16·3 2·47 g) and IGF-I (15·8 1·97 g) treatment compared with saline (9·2 1·96 g). Whole spleen, kidney and carcass weights were significantly (P<0·05) increased in ad libitum fed and 30% ad libitum fed dams with GH treatment. Circulating IGF-I was significantly increased (P<0·001) in ad libitum fed dams with both IGF-I (369·6 32·33 ng/ml) and GH (457·9 33·32 ng/ml) compared with saline treatment (211·7 14·02 ng/ml), and with GH (223·4 23·72 ng/ml) compared with saline treatment (112·0 7·33 ng/ml) in 30% ad libitum fed dams. Circulating GH binding protein (GHBP) levels were significantly reduced (P<0·05) in GH-treated (299·1 51·54 ng/ml) compared with saline-treated (503·9 62·43 ng/ml) ad libitum fed dams, but were not altered in 30% ad libitum fed dams. There was no significant effect of either IGF-I or GH treatment on fetal weight, placental weight, fetal organ weights or circulating IGF-I levels in both ad libitum fed and 30% ad libitum fed fetuses. Offspring of 30% ad libitum fed dams remained significantly growth retarded postnatally and showed elevated blood pressure in later life. The increased maternal weight gain following IGF-I or GH administration, without an effect on fetal and placental weights, suggests a modification in the mode of maternal nutrient repartitioning during mid to late pregnancy at the expense of the fetus.

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Changes in serum concentrations of ACTH, corticosterone and in growth following morning or evening injection of female rats with porcine growth hormone

Cited by 10 publications

References 19 publications

Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats

Effects of Short-Term Treatment with Recombinant Human Growth Hormone on Carbamazepine Pharmacokinetics in Rats

Elevated Corticosterone Levels in Transgenic Mice Expressing Human or Bovine Growth Hormone Genes

Administration of growth hormone or IGF-I to pregnant rats on a reduced diet throughout pregnancy does not prevent fetal intrauterine growth retardation and elevated blood pressure in adult offspring

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