Changes in serum cytokine levels during plasmapheresis in patients with myasthenia gravis

Abstract

Interleukin-10 might play a crucial role in the pathogenesis and perpetuation of MG.

Altered let-7 expression in Myasthenia gravis and let-7c mediated regulation of IL-10 by directly targeting IL-10 in Jurkat cells

“…It is reported that T-helper lymphocytes and cytokines probably participate in the development of MG [3]. It has been shown that IL-10 level was significantly higher in MG patients than in controls and correlated well with clinical severity [4]. In addition, the number of immune cells secreting IL-2, IL-4, interferon (IFN)-γ, and IL-10 has been shown to be significantly higher in patients with MG than in healthy individuals [5][6][7].…”

Serum proteomic, peptidomic and metabolomic profiles in myasthenia gravis patients during treatment with Qiangji Jianli Fang

“…Kallidin is a pro-inflammatory kinin peptide that acts as a stimulant for several inflammatory cytokines, such as tumor necrosis factor, interleukin-1 and interleukin-6, and is involved in many physiological and pathological processes [58]. Abnormal serum cytokine levels were shown to be related to the pathogenesis of MG [40]. The decrease in kallidin II after QJF treatment may inhibit the stimulation of cytokines and reduce the activity of inflammatory molecules in MG patients.…”

“…Abnormal serum cytokine levels were also detected [40-42]. In addition, analyses of blood proteomic, peptidomic and metabolomic profiles have been employed to elucidate the pathological mechanisms of diseases and to evaluate the efficiency of drug treatments [43,44].…”

Immunopathogenesis of Myasthenia Gravis (Review)

“…в нервно-мышечных структурах [101,103,115]. В качестве посредников они принимают участие в дифференцировке иммунокомпетентных и гемо-поэтических клеток, в формировании механизмов межклеточного взаимодействия, лежащих в осно-ве иммунного ответа.…”