Changes in serum cytokines in response to musculoskeletal surgical trauma

Reikerås, Olav; Borgen, Pål O.; Reseland, Janne Elin; Lyngstadaas, Ståle Petter

doi:10.1186/1756-0500-7-128

Cited by 49 publications

(49 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, the sample size restricted to interpret of the obtained data in the present study. Slight increased levels of pro-inflammatory cytokines IL-1, IL-6 due to their stimulator effects on TNF-α production raised the level significantly, meanwhile slight elevation on the level of anti-inflammatory cytokine IL-10 might explain as a consequence of the thyroidectomy operation in accordance with previous studies [19,21] .…”

Section: Kandir Keski̇nsupporting

confidence: 78%

“…Especially IL-1β and TNF-α, IL-6 and C-reactive protein, which is a predictor for acute-phase response and IL-10 have been used in biomarkers for monitoring traumatic inflammation and recovery period in clinically both human and veterinary medicine [18][19][20] . Ozcinar et al [21] reported the pro-inflammatory cytokines IL-1β and TNF-α levels were higher after thyroid surgery in human.…”

Section: Kandir Keski̇nmentioning

confidence: 99%

See 1 more Smart Citation

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Kandir¹,

Keskin²

2015

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

This study was conducted to determine the serum levels of interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor alpha (TNF-α) in thyroidectomized rats. Hypothyroidism was performed by surgical thyroidectomy in rats. Four weeks after from surgical procedure, selected cytokines levels were evaluated. Hypothyroidism was confirmed by elevated thyroid stimulating hormone (TSH) and decreased free tri-iodothyronine (fT3) levels (P<0.05) in thyroidectomized group. Serum IL-1β, IL-6, IL-10 levels have shown slight increase, whereas only TNF-α level (P<0.05) were significant statistically in thyroidectomized rats compared with control group. In conclusion, the obtained data suggest that elevated levels of cytokines could be as a consequence of thyroidectomy operation. Keywords: Cytokine, Immune function, Rodent, Thyroid alteration, Trauma Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri ÖzetBu çalışmada, tiroidektomize ratların serum interlökin (IL)-1β, IL-6, IL-10 and TNF-α düzeylerinin belirlenmesi amaçlanmıştır. Hipotiroidizm cerrahi yolla tiroidektomi yapılarak gerçekleştirildi. Cerrahi işlemden sonraki 4. haftada, seçili sitokinlerin seviyeleri ölçüldü. Hipotiroidizm, tiroidektomize grubun tiroid uyarıcı hormon (TSH) düzeyindeki artış (P<0.05) ve serbest tri-iyodotironin (fT3) düzeyindeki azalış (P<0.05) ile teyit edildi. Tiroidektomize ratların serum IL-1β, IL-6, IL-10 seviyelerinin kontrol grubuna kıyasla hafif düzeyde yükseldiği ancak, sadece TNF-α düzeyindeki artışın istatistiki olarak anlamlı (P<0.05) olduğu görüldü. Sonuç olarak elde edilen veriler, sitokin seviyelerindeki yükselmenin, tiroidektomi operasyonunun bir sonucu olabileceğini düşündürmektedir.

show abstract

Section: Kandir Keski̇nsupporting

confidence: 78%

Section: Kandir Keski̇nmentioning

confidence: 99%

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Kandir¹,

Keskin²

2015

Kafkas Univ Vet Fak Derg

View full text Add to dashboard Cite

show abstract

“…12,37 Previous studies demonstrated the induction of local and systemic inflammatory reactions with production of IL-6 as early as 6 hours after musculoskeletal surgical trauma. 38 In addition, IL-6 shows a distinctive circadian biphasic variation, with concentrations peaking at 4:00 pm and 4:00 am.…”

Section: Discussionmentioning

confidence: 99%

Release Kinetics of Inflammatory Biomarkers in a Clinical Model of Acute Myocardial Infarction

Liebetrau

Hoffmann

Dörr

et al. 2015

Circulation Research

View full text Add to dashboard Cite

In this context, high-sensitivity (hs) assays for CRP have been developed that provide both diagnostic and prognostic information. 14,15,17 Studies have shown that hs assays detect CRP concentrations with the required precision even in patients Rationale: Inflammation in the setting of acute myocardial infarction (MI) has been linked to risk stratification; however, the release kinetics of inflammatory biomarkers in patients with acute MI has been difficult to establish.Objective: The aim of this study was to determine the kinetics of changes in the levels of several biomarkers specifically linked to inflammation after transcoronary ablation of septal hypertrophy, a procedure that mimics acute MI. Methods and Results:We analyzed release kinetics of C-reactive protein, high-sensitivity C-reactive protein,

show abstract

“…B cell differentiation occurs in two phases: the antibodyindependent and antibody-dependent phases. Reikeras et al showed that serum IL-6 significantly increases between 1 and 3 days after hip replacement surgery, 17 and Soto et al reported that serum IL-6 increases significantly after 1 week following aortic valve replacement. These then become antibody-dependent in peripheral lymphatic tissues, and differentiate into antibody-producing plasma cells through na€ ıve B cells, memory B cells and plasmablasts.…”

Section: Discussionmentioning

confidence: 99%

Association between peripheral plasmablasts and postoperative exacerbation in patients with thymoma‐associated myasthenia gravis

Izaki

Tanaka

Oji

et al. 2019

Clinical & Exp Neuroim

View full text Add to dashboard Cite

Objective Thymoma-associated myasthenia gravis (TAMG) is a type of myasthenia gravis (MG) that has a higher likelihood of worsening in comparison with non-TAMG, and MG symptoms often worsen after thymectomy. We measured peripheral T/B lymphocyte subsets before and after thymectomy in TAMG patients, and investigated the relationships with the occurrence of postoperative exacerbation of MG symptoms. Methods Participants were 10 TAMG patients, 40 healthy controls and five other surgical control patients. Peripheral lymphocyte subsets were measured using FACS-Canto flow cytometry before, and 1, 7, and 28 days after thymectomy in the TAMG, and before and 7 days after thymectomy in the other surgical control patients. Results Natural killer cells modestly decreased, and plasmablasts increased significantly (P = 0.005) after 7 days postoperatively in comparison with preoperative values. Conversely, no obvious changes were observed in plasmablasts or natural killer cells in T/B lymphocyte subsets. From evaluation of postoperative clinical course and plasmablasts, exacerbation of MG symptoms was observed between 2 and 3 weeks after thymectomy in five of 10 patients (50%) of TAMG. In these five patients, plasmablasts markedly increased after thymectomy in three patients, among whom two patients had originally shown high plasmablast levels before thymectomy. There were also two patients who exacerbated without changes in plasmablast levels.Conclusions In patients with exacerbation of neurological symptoms after thymectomy for TAMG, the plasmablast levels were originally high and/or became high postoperatively. Thus, elevated plasmablast levels could potentially be predictive of postoperative exacerbation of MG.

show abstract

Changes in serum cytokines in response to musculoskeletal surgical trauma

Cited by 49 publications

References 31 publications

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Tiroidektomize Ratlarda Serum IL-1β, IL-6, IL-10 ve TNF-α Seviyeleri

Release Kinetics of Inflammatory Biomarkers in a Clinical Model of Acute Myocardial Infarction

Association between peripheral plasmablasts and postoperative exacerbation in patients with thymoma‐associated myasthenia gravis

Contact Info

Product

Resources

About