Changes in serum miRNA-let-7 level in children with attention deficit hyperactivity disorder treated by repetitive transcranial magnetic stimulation or atomoxetine: An exploratory trial

Cao, Pengfei; Wang, Linxiao; Cheng, Qi; Sun, Xiaojing; Kang, Qinglin; Dai, Libin; Zhou, Xianju; Song, Zhimin

doi:10.1016/j.psychres.2019.02.037

Cited by 22 publications

(19 citation statements)

References 26 publications

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“…As stated by Cao et al, (2019) there was a significant improvement in attention deficit, hyperactive impulse and oppositional defiance (p=0.000) observed on the SNAP-IV scale after six weeks (6 sessions/week; each session lasting 30 minutes) of rTMS treatment applied at right dorsolateral prefrontal cortex (DLPFC).…”

Section: Effect Of Interventions 331 Repetitive Transcranial Magnetic Stimulation (Rtms)mentioning

confidence: 73%

“…tDCS is a non-invasive electric brain stimulation which involves the use of an electric current of low amplitude applied via electrodes placed on the scalp [11] . rTMS is another non-invasive brain stimulation includes the use of a magnetic coil placed over a specific area of the brain and is useful in inducing long term changes in cortical excitability [8,12] . Both rTMS and tDCS have been previously used in pediatric population and now being used as an intervention for ADHD.…”

Section: Introductionmentioning

confidence: 99%

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Winning over ADHD by charging the brain non-invasive stimulation methods in ADHD: A systematic review

Makkar¹,

Arumugam²,

Midha³

2021

Int. J. Appl. Res.

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Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder characterized primarily by either hyperactivity or inattention or both. Non-Invasive brain stimulation techniques including Transcranial direct current stimulation (tDCS) and Repetitive Transcranial magnetic stimulation (rTMS) act by altering brain activity and modulating neuronal networks. Both rTMS and tDCS have been previously used in pediatric population and now being used as an intervention for ADHD. The aim of this study was to review the existing literature on Non-Invasive stimulation in ADHD as a means of treatment. An English Language Literature search using Google Scholar, Scopus, PubMed and Pedro was done to identify the data. PRISMA guidelines were followed and those studies which fulfilled the specific requirements were selected. Methodological quality of these studies was assessed using PEDro scale. In accordance with the inclusion criteria; eight studies done between 2010 and 2019 were reviewed. Studies were grouped according to intervention given: rTMS and tDCS. Our findings reveal that both rTMS and tDCS have positive effects on improving inhibitory control, executive function as well as the impulsive symptoms in ADHD. It was concluded that Non-invasive stimulation is a promising and upcoming tool for improving executive functions and inhibitory control in ADHD. More number of high quality randomized control trials are required to strengthen the evidence and incorporation of these tools in clinical practice.

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Section: Effect Of Interventions 331 Repetitive Transcranial Magnetic Stimulation (Rtms)mentioning

confidence: 73%

Section: Introductionmentioning

confidence: 99%

Winning over ADHD by charging the brain non-invasive stimulation methods in ADHD: A systematic review

Makkar¹,

Arumugam²,

Midha³

2021

Int. J. Appl. Res.

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“…For example, the clinical trial performed by Cao et al inferred that rTMS could attenuate attention deficit hyperactivity disorder in children by suppressing let-7d levels. 29 The study by Liu et al showed that rTMS promoted the proliferation of neural progenitor cells by increasing the levels of miR-106. 20 These results suggested that miRNAs may be crucial for the function of rTMS.…”

Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer’s Disease in Mice by Modulating the miR-567/NEUROD2/PSD95 Axis

Pang¹,

Shi²

2021

NDT

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Background Mild cognitive impairment (MCI) is a typical symptom of early Alzheimer’s disease (AD) and is driven by the dysfunction of microRNAs (miRs). Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive technique for handling neuropsychiatric disorders and has universally effects on the functions of miRs. In the current study, the improvement effects of rTMS on MCI associated with AD were explored by focusing on miR-567/NEUROD2/PSD95 axis. Methods MCI was induced in mice using scopolamine and was treated with rTMS of two frequencies (1 Hz and 10 Hz). The changes in cognitive function, brain structure, neurotrophic factor levels, and activity of miR-567/NEUROD2/PSD95 axis were assessed. The interaction between rTMS and miR-567 was further verified by inducing the level of miR-567 in AD mice. Results The administrations of rTMS improved the cognitive function of AD mice and attenuated brain tissue destruction, which were associated with the restored production of BDNF and NGF. Additionally, rTMS administrations suppressed the expression of miR-567 and up-regulated the expressions of NEUROD2 and PSD95, which contributed to the improved condition in central nerve system. With the induced level of miR-567, the effects of rTMS were counteracted: the learning and memorizing abilities of mice were impaired, the brain neuron viability was suppressed, and the production of neurotrophic factors was suppressed even under the administration of rTMS. The changes in brain function and tissues were associated with the inhibited expressions of NEUROD2 and PSD95. Conclusion The findings outlined in the current study demonstrated that rTMS treatment could protect brain against AD-induced MCI without significant side effects, and the function depended on the inhibition of miR-567.

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“…Furthermore, the low correlation of miRNA levels between cord and maternal samples holds promise for our future work where we will evaluate the potential of using miRNA expression profiles in cord blood plasma as early biomarkers of ADHD and other neurodevelopmental disorders. [40][41][42] hsa-let-7d-5p 2.03 ±0. 45 1.94 ±0.44 Increased in serum, decreased in WB.…”

Section: Discussionmentioning

confidence: 99%

“…45 1.94 ±0.44 Increased in serum, decreased in WB. [40][41][42] hsa-let-7g-5p 3.23 ±1. 24 2.87 ±1.32 Part of ADHD-prediction model in WBCs [43] hsa-miR-101-3p 2.13 ±0.…”

Section: Discussionmentioning

confidence: 99%

MiRNA profiles in blood plasma from mother-child duos in human biobanks and the implication of sample quality: Circulating miRNAs as potential early markers of child health

et al. 2020

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BackgroundMicroRNAs (miRNAs) have been linked to several diseases and to regulation of almost every biological process. This together with their stability while freely circulating in blood suggests that they could serve as minimal-invasive biomarkers for a wide range of diseases. Successful miRNA-based biomarker discovery in plasma is dependent on controlling sources of preanalytical variation, such as cellular contamination and hemolysis, as they can be major causes of altered miRNA expression levels. Analysis of plasma quality is therefore a crucial step for the best output when searching for novel miRNA biomarkers. MethodsPlasma quality was assessed by three different methods in samples from mother-child duos (maternal and cord blood, N = 2x38), with collection and storage methods comparable to large cohort study biobanks. Total RNA was isolated and the expression profiles of 201 miR-NAs was obtained by qPCR to identify differentially expressed miRNAs in cord and maternal plasma samples. ConclusionsOur findings suggest that good quality plasma samples suitable for miRNA profiling can be achieved from samples collected and stored by large biobanks. Incorporation of extensive quality control measures, such as those established here, would be beneficial for future projects. The overall low correlation of miRNA expression between cord and maternal samples is an interesting observation, and promising for our future studies on identification of miRNA-based biomarkers in cord blood plasma, considering that these samples were collected at term and some exchange of blood components between cord and maternal blood frequently occur. IntroductionThe finding of circulating microRNAs (miRNA) in body fluids (blood plasma, serum or urine) [1,2] has opened up for the possibility of using blood-based miRNAs as a new approach for diagnostic screening. MiRNAs have been linked to cancer and several other diseases [3], and they have been implicated in promoting neurodevelopmental processes, such as neurogenesis, synapse precursor formation, and synaptic plasticity [4,5]. The stability of miRNAs circulating in blood, and their role as key regulators of almost every biological process, including precise control of neuronal gene expression and thus fine-tuning signaling pathways [6], suggests that they could serve as non-invasive biomarkers for a wide range of diseases [7][8][9], and possibly help explain basic disease etiology. Furthermore, miRNAs have been shown to be targeted by epigenetic modification, and in turn, miRNAs can target regulators of epigenetic pathways [10,11].Blood-based biobanks, which include collection of umbilical cord blood, such as the Mother, Father and Child Cohort Study (MoBa) biobank [12] at the Norwegian Institute of Public Health (NIPH), and other multi-center studies, increasingly incorporate studies identifying candidate mRNA and miRNA expression profile-based biomarkers for a wide range of disorders. The combination of biological specimens and questionnaire data on lifestyle and exposures in MoBa prov...

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Changes in serum miRNA-let-7 level in children with attention deficit hyperactivity disorder treated by repetitive transcranial magnetic stimulation or atomoxetine: An exploratory trial

Cited by 22 publications

References 26 publications

Winning over ADHD by charging the brain non-invasive stimulation methods in ADHD: A systematic review

Winning over ADHD by charging the brain non-invasive stimulation methods in ADHD: A systematic review

Repetitive Transcranial Magnetic Stimulation Improves Mild Cognitive Impairment Associated with Alzheimer’s Disease in Mice by Modulating the miR-567/NEUROD2/PSD95 Axis

MiRNA profiles in blood plasma from mother-child duos in human biobanks and the implication of sample quality: Circulating miRNAs as potential early markers of child health

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