Changes in sexual hormones, serotonin, and cortisol concentrations following oral administration of melatonin in castrated and intact dogs

Salavati, Sina; Mogheiseh, Asghar; Nazifi, Saeed; Tabrizi, Ali; Taheri, Pegah; Koohi, Farzaneh

doi:10.1016/j.jveb.2018.06.044

Cited by 14 publications

(28 citation statements)

References 27 publications

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“…In our previous study, we examined the effects of melatonin treatment on the levels of sexual hormones, serotonin, and cortisol in intact and castrated male dogs. The results showed that melatonin increased the level of serotonin but decreased the level of cortisol in intact and castrated dogs [ 13 ]. This study indicated that postoperative stress (increased cortisol concentration) continued for 1 week after castration and daily melatonin administration decreased cortisol concentration during 7 days after gonadectomy in castrated dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Melatonin could regulate metabolic hormones and mitigate the metabolic side-effects of castration [ 15 ]. Long-term side effects of castration and beneficial effect of melatonin were reported in these studies [ 13 , 15 ]. The melatonin treatment after gonadectomy may be suggested for prevention of metabolic disorders in gonadectomized dogs.…”

Section: Discussionmentioning

confidence: 99%

“…Under special conditions, the neuroendocrine cells of other organs, including the thyroid gland, retina, skin, and gastrointestinal tract, can also produce melatonin in vertebrates [ 12 ]. In our previous experiments, we found that melatonin could have anti-oxidative, anti-inflammatory, and anti-stress (based on cortisol level) effects and regulate the secretion of metabolic hormones in dogs following castration [ 13 – 16 ].…”

Section: Introductionmentioning

confidence: 99%

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The effects of melatonin treatment on oxidative stress induced by ovariohysterectomy in dogs

et al. 2021

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Background As one of the most common surgeries performed in veterinary medicine, ovariohysterectomy (OHE) can induce oxidative stress in dogs. The antioxidant properties of melatonin have been confirmed in various studies. This study aimed to investigate the effects of melatonin administration on oxidative stress in dogs before and after OHE. In this study, 25 mature female intact dogs were selected and randomly divided into five equal groups: Melatonin (melatonin, no surgery), OHE (no melatonin, surgery), OHE + melatonin (melatonin, surgery), anesthesia+melatonin (melatonin, sham surgery), and control (no melatonin, no surgery) groups. Melatonin (0.3 mg/Kg/day, p.o.) was administrated to the dogs in the melatonin, OHE + melatonin, and anesthesia+melatonin groups on days − 1, 0, 1, 2, and 3 (day 0 = OHE). Blood sampling was performed on days − 1, 1, 3, and 5 of the study. Blood samples were immediately transferred to the laboratory and sera were separated and stored at − 20 °C. Superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT) and malondialdehyde (MDA) concentrations were measured with commercial kits. Results The levels of SOD, GPX and CAT were significantly higher in the melatonin and anesthesia+melatonin groups compared to those of the control group at days 3 and 5. The level of antioxidant enzymes significantly decreased in the OHE group compared to that of other groups at days 3 and 5. The administration of melatonin increased the level of antioxidant enzymes in ovariohysterectomized dogs. Ovariohysterectomy significantly increased the concentration of MDA in comparison to that of other groups at day 3. Melatonin administration significantly decreased the level of MDA in melatonin, anesthetized, and ovariohysterectomized dogs at day 3. Conclusions Administration of melatonin on day − 1, 0, 1, 2 and 3 modulate the oxidative stress induced by OHE in dogs by increasing antioxidant enzymes concentration and decreasing MDA levels.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The effects of melatonin treatment on oxidative stress induced by ovariohysterectomy in dogs

et al. 2021

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“…Salavati et al (2018) examined the effects of melatonin treatment on the levels of sexual hormones, serotonin, and cortisol in intact and castrated male dogs. Their results showed that melatonin increased the level of serotonin but decreased the level of cortisol in intact and castrated dogs [16]. Taheri et al (2019) also studied the effects of melatonin administration on the levels of thyroid hormones, leptin, and ghrelin in intact and castrated male dogs.…”

Section: Discussionmentioning

confidence: 99%

“…As in our previous studies, melatonin was administrated daily just before and after spaying. Also, since the effect of anesthesia on oxidative stress had to be examined in comparison with other groups [16][17][18][19], the dogs were divided into ve equal groups (n = 5) in a case-control randomized study (Fig. 1).…”

Section: Experimental Designmentioning

confidence: 99%

The Effects of Melatonin Treatment on Oxidative Stress Induced by Ovariohysterectomy in Dogs

Salavati

Mogheiseh

Nazifi

et al. 2020

Preprint

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Background: As one of the most common surgeries performed in veterinary medicine, ovariohysterectomy (OHE) can induce stress in dogs. The antioxidant properties of melatonin have been confirmed in various studies. This study aimed to investigate the effects of melatonin administration on oxidative stress in dogs before and after OHE. In this study, 25 mature female intact dogs were selected and randomly divided into five equal groups: Melatonin, OHE, melatonin+OHE+melatonin, melatonin+anesthesia+melatonin, and control groups. Melatonin (0.3 mg/Kg/day, p.o.) was administrated to the dogs in the melatonin, melatonin+OHE+melatonin, and melatonin+anesthesia+melatonin groups on days -1, 1, 2, and 3 (day 0=OHE). Blood sampling was performed on days -1, 1, 3, and 5 of the study. Blood samples were immediately transferred to the laboratory and sera were separated and stored at -20 °C. Superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT) concentrations were significantly higher in the melatonin and melatonin+anesthesia+melatonin groups compared to those of the control group. Results: The level of antioxidant enzymes significantly decreased in the OHE group compared to that of other groups. The administration of melatonin increased the level of antioxidant enzymes in ovariohysterectomized dogs. OHE significantly increased the concentration of malondialdehyde (MDA) in comparison to that of other groups. Melatonin administration significantly decreased the level of MDA in intact, anesthetized, and ovariohysterectomized dogs. Conclusions: It can be stated that the administration of melatonin one day before and during one week after OHE could control oxidative stress in dogs with increased antioxidant enzymes and decreased MDA levels.

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The effects of melatonin on the concentrations of inflammatory cytokines and proteins, serotonin, cortisol and melatonin in ovariohysterectomised female dogs

Salavati

Mogheiseh

Nazifi

et al. 2023

Veterinary Medicine & Sci

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Background: Ovariohysterectomy (OHE) induces inflammation and stress in female dogs. The anti-inflammatory effects of melatonin have been reported in several studies. Objectives:The goal of this study was to assess the effects of melatonin on the concentrations of melatonin, cortisol, serotonin, α-1-acid glycoprotein (AGP), serum amyloid A (SAA), c-reactive protein (CRP), interleukin-10 (IL-10), interleukin-8 (IL-8), interleukin-1β (IL-1β) and tumour necrosis factor-α (TNF-α) before and after OHE. Methods:The total number of animals was 25 and aligned in 5 groups. Fifteen dogs were divided into three groups (n = 5): melatonin, melatonin+anaesthesia and melatonin+OHE and received melatonin (0.3 mg/kg, p.o.) on days -1, 0, 1, 2 and 3. Ten dogs were assigned to the control and OHE groups (n = 5) without melatonin treatment. OHE and anaesthesia were performed on day 0. Blood samples were obtained via jugular vein on days -1, 1, 3 and 5.Results: Melatonin and serotonin concentrations significantly increased in the melatonin, melatonin+OHE and melatonin+anaesthesia groups compared with the control group, while cortisol concentration decreased in the melatonin+OHE group compared with the OHE group. The concentrations of acute-phase proteins (APPs) and inflammatory cytokines significantly increased after OHE. The CRP, SAA and IL-10 concentrations decreased significantly in the melatonin+OHE group compared with the OHE group. The concentrations of cortisol, APPs and proinflammatory cytokines increased significantly in the melatonin+anaesthesia group compared with the melatonin group. Conclusions:The oral administration of melatonin before and after OHE help controlling the high levels of inflammatory APPs, cytokines and cortisol induced by OHE in female dogs.

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Changes in sexual hormones, serotonin, and cortisol concentrations following oral administration of melatonin in castrated and intact dogs

Cited by 14 publications

References 27 publications

The effects of melatonin treatment on oxidative stress induced by ovariohysterectomy in dogs

The effects of melatonin treatment on oxidative stress induced by ovariohysterectomy in dogs

The Effects of Melatonin Treatment on Oxidative Stress Induced by Ovariohysterectomy in Dogs

The effects of melatonin on the concentrations of inflammatory cytokines and proteins, serotonin, cortisol and melatonin in ovariohysterectomised female dogs

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