This study seeks to investigate and understand the perceptions of and lifestyle changes adopted by healthcare workers (HCWs) in Turkey who were on the front line of the fight against the outbreak of COVID-19. A total of 33 female HCWs with bachelor’s degrees were included in the study. In-depth interview techniques were used. The data analysis was performed with MAXQDA 2020 qualitative data analysis package program. The female HCWs perceived COVID-19 as rapidly contagious, deadly, dangerous, and long-term. Their perception as to the cause of the outbreak was akin to conspiracy thoughts such as bioweapon. In addition, the study determined that social media was the preferred medium for getting news because the news given in the traditional media was not trusted. It was seen that the attitude of participants regarding the preventive measures was in line with the recommendations of international organizations. In terms of lifestyle changes, for example, the dietary habits and physical activity levels of all the HCW participants, changed and online environments were used for communication/socialization. Those HCW participants who smoked, stated that smoking increased the risk and severity of COVID-19, and they declared an increase in the amount of their use. Those HCW participants who consumed alcohol, reported that alcohol consumption increased during the period of the outbreak in order to maintain socialization and relaxation. Those HCW participants who did not smoke or drink alcohol mentioned that they did not intend to start. This study contributes to an understanding of the impact on HCWs of significant health events especially in terms of their perceptions of and their lifestyle changes as a result of such health events.