2000
DOI: 10.1164/ajrccm.161.1.9809100
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Changes in Sputum Eosinophils Predict Loss of Asthma Control

Abstract: Exacerbations of asthma are likely to be due to an increase in airway inflammation. We have studied noninvasive markers of airway inflammation in asthma exacerbations induced by reducing the dose of inhaled corticosteroids. Following a 2-wk run-in period, mild exacerbations were induced in subjects with stable asthma controlled with medium- to high-dose inhaled corticosteroids (beclomethasone dipropionate >/= 800 microg or equivalent daily) by switching them to budesonide 200 microg daily given from a dry-powd… Show more

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Cited by 372 publications
(233 citation statements)
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“…[11][12][13] It is well-recognized that the total eosinophil count in induced sputum reflects asthmatic activity and is useful for adjusting steroid dosage and for early detection of exacerbations. 14,15 The involvement of Siglec-8 in eosinophil apoptosis supports the hypothesis that Siglec-8 may have a role in eosinophil-mediated asthma, allergic inflammation, and EE. Thus, abnormalities in Siglec-8 function due to genetic variations could be associated with the pathogenesis of asthma and other eosinophil-associated diseases.…”
Section: Introductionsupporting
confidence: 59%
“…[11][12][13] It is well-recognized that the total eosinophil count in induced sputum reflects asthmatic activity and is useful for adjusting steroid dosage and for early detection of exacerbations. 14,15 The involvement of Siglec-8 in eosinophil apoptosis supports the hypothesis that Siglec-8 may have a role in eosinophil-mediated asthma, allergic inflammation, and EE. Thus, abnormalities in Siglec-8 function due to genetic variations could be associated with the pathogenesis of asthma and other eosinophil-associated diseases.…”
Section: Introductionsupporting
confidence: 59%
“…However, recent studies using a humanized antibody to interleukin-5 (IL-5), which inhibits accumulation of eosinophils, have provided persuasive evidence that AHR can develop in the absence of eosinophil recruitment (Leckie et al, 2000). Nevertheless, eosinophils clearly do play a major role in acute asthma, and an increased number of eosinophils in sputum is predictive of an exacerbation of the illness (Jatakanon et al, 2000). Inhibition of recruitment of eosinophils is therefore attractive as a potential therapeutic strategy.…”
mentioning
confidence: 99%
“…La modification du nombre d'éosinophiles de l'expectoration est un marqueur potentiellement utile dans la prédiction de la perte de contrôle de l'asthme reflétée par une perte de fonction pulmonaire [39] . Une étude prospective récente [40] a également montré une corrélation entre le pourcentage d'éosinophiles pré-sents dans l'expectoration et le déclin du VEMS à 5 ans.…”
Section: Intérêt Dans La Prédiction Du Déclin De La Fonction Respiratunclassified
“…Dans une étude transversale de patients asthmatiques [42] , Quaedvlieg et al ont montré des taux accrus d'éosinophiles dans les expectorations de patients dont l'asthme était non contrôlé sur base d'un score Asthma Control Questionnaire (ACQ) de Juniper [43] supérieur à 1,5. Jatakanon a montré que le pourcentage d'éosinophiles pré-sents dans l'expectoration est un facteur prédictif d'une perte de contrôle de l'asthme [39] . Dans une autre étude, Leuppi a rapporté qu'un pourcentage d'éosinophiles supérieur au seuil de 6,3 % avait une sensibilité de 90 % et une spécificité de 63 % pour la prédiction d'une perte de contrôle de l'asthme lors du sevrage en corticostéroïdes inhalés [44] .…”
Section: Intérêt Dans L'évaluation Du Contrôle Et De La Sévérité De Lunclassified