Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet's disease

Ishikawa, Sho; Taguchi, Manzo; Muraoka, Tadashi; Sakurai, Yoshinori; Kanda, Teppei; Takeuchi, Masaru

doi:10.1136/bjophthalmol-2014-305333

Cited by 103 publications

(90 citation statements)

References 22 publications

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“…Recently, a new method of SD-OCT, termed enhanced depth imaging (EDI), has been shown to be capable of visualizing the full thickness of the choroid (8) . Changes in choroidal thickness have previously been reported in a number of autoimmune and systemic inflammatory disorders (9)(10)(11)(12)(13) . To the best of our knowledge, studies using EDI-OCT to evaluate choroidal segment involvement in patients with IBD have yet to be reported.…”

Section: Introductionmentioning

confidence: 94%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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Approved by the following research ethics committee: Gazi University Ethics Committee. Number N o 53 -26/01/2015. ABSTRACTPurpose: Ocular inflammation is a frequent extraintestinal manifestation of inflammatory bowel disease (IBD) and may parallel disease activity. In this study, we evaluated the utility of a choroidal thickness measurement in assessing IBD activity. Methods: A total of 62 eyes of 31 patients with IBD [Crohn's disease (CD), n=10 and ulcerative colitis (UC), n=21] and 104 eyes of 52 healthy blood donors were included in this study. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. The Crohn's disease activity index (CDAI) and the modified Truelove Witts score were used to assess disease activity in CD and UC, respectively. Results: No significant differences in mean subfoveal, nasal 3000 µm, or temporal 3000 µm choroidal thickness measurements (P>0.05 for all) were observed between IBD patients and healthy controls. Age, smoking, CD site of involvement (ileal and ileocolonic involvement), CDAI, CD activity, and UC endoscopic activity index were all found to be significantly correlated with choroidal thickness by univariate analysis (P<0.05). Smoking (P<0.05) and the CD site of involvement (P<0.01) were the only independent parameters associated with increased choroidal thickness at all measurement locations. Conclusions: Choroidal thickness is not a useful marker of disease activity in patients with IBD but may be an indicator of ileal involvement in patients with CD.

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Section: Introductionmentioning

confidence: 94%

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Önal¹,

Yüksel²,

Bayrakceken³

et al. 2015

Arquivos Brasileiros De Oftalmologia

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“…Ishikawa et al and Kim et al reported that subfoveal choroidal thickness was significantly higher during an acute attack of Behçet's uveitis than in remission. Their choroid was found thicker than that of healthy control subjects not only during an attack of Behçet's uveitis but also during remission of the disease [36,37].…”

Section: Complementary Imaging Modalities and Laboratory Testsmentioning

confidence: 72%

Ocular Manifestations of Behçet’s Disease

Şahlı¹,

Gurbuz-Koz²

2017

Behcet's Disease

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Behçet's disease (BD) is a multisystemic autoimmune inflammatory disorder characterized by oral aphthous lesions, genital ulcerations, iridocyclitis with hypopyon, and skin lesions. While ocular manifestations occur in nearly 50% of the patients with Behçet's disease, ocular involvement is the initial manifestation in only less than 20% of the patients. Ocular Behçet's disease clinically presents iridocyclitis with or without hypopyon, vitritis, retinitis, occlusive retinal vasculitis, and cystoid macular edema. However, anterior uveitis is usually the only initial ocular manifestation; the most common form is panuveitis. The usual course of the disease is characterized by recurrent inflammatory periods. Recurrent inflammatory attacks may result in irreversible damage and significant visual loss. Early and effective treatment is required to prevent ocular morbidity. Recent developments in the treatment of ocular Behçet's disease like biological agents are promising with a rapid effect and high remission rates.

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“…Detailed visualisation of the choroid in vivo is now possible thanks to enhanced depth imaging (EDI) optical coherence tomography (OCT) (10). Various studies that have used OCT to evaluate CT in several systemic autoimmune and infl ammatory disorders are available (11)(12)(13)(14). The aim of our study was to evaluate the choroidal thickness (CT) in patients with rheumatoid arthritis (RA) and detectthe relation with disease activity and joint damage in patients with rheumatoid arthritis, additionally compare it with healty controls.…”

Section: Introductionmentioning

confidence: 99%

Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis

Kurt¹,

Kurt²,

Kılıç³

et al. 2017

BLL

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OBJECTIVE: Aim of the study was to evaluate the choroidal thickness (CT) in patients with RA and detect the relation with disease activity and joint damage in patients with rheumatoid arthritis BACKGROUND: Rheumatoid arthritis (RA) is a systemic infl ammatory disease associated with various extraarticular organ manifestations including ocular manifestations MATERIALS AND METHODS: We included 59 eyes of 59 patients with RA and 59 eyes of 59 controls without RA in the study. Subfoveal and perifoveal CT were measured using enhanced depth imaging optic coherence tomography. Disease activity score 28 (DAS 28) and Larsen score were calculated for each patient with RA and compared with measurements of CT. RESULTS: CT was statistically thinner in patients with RA than controls, at subfoveal CT (p = 0.008), at 500 μm temporal to the fovea (p = 0.004), at 1000 μm temporal to the fovea (p = 0.010), at 1500 μm temporal to the fovea (p = 0.005), at 500 μm nasal to the fovea (p = 0.035). Additionally there was no correlation measurements of CT with disease activity and joint damage. CONCLUSIONS: Subfoveal and perifoveal CT was signifi cantly thinner in patients with RA than in healthy controls but there was no correlation detected between CT measurements and DAS 28 or Larsen scores (Tab. 5, Ref. 33). Text in PDF www.elis.sk.

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Changes in subfoveal choroidal thickness associated with uveitis activity in patients with Behçet's disease

Abstract: This study indicates that measurement of subfoveal choroidal thickness by EDI-OCT is useful for evaluating the activity of uveitis and the therapeutic efficacy in patients with BD.

Cited by 103 publications

References 22 publications

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Measurement and clinical implications of choroidal thickness in patients with inflammatory bowel disease

Ocular Manifestations of Behçet’s Disease

Is choroidal thickness related with disease activity and joint damage in patient with rheumatoid arthritis

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