Changes in T-cell phenotype and cytokines profile in maternal blood, cord blood and colostrum of diabetic mothers

Fagundes, Danny Laura Gomes; França, Eduardo Luzía; Fernandes, Rubian Trindade da Silva; Hara, Cristiane de Castro Pernet; Morceli, Glilciane; Honório-França, Adenilda Cristina; Calderon, Iracema de Mattos Paranhos

doi:10.3109/14767058.2015.1031739

Cited by 28 publications

(27 citation statements)

References 28 publications

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“…In this study, we report that CB retains a lower proportion of CD3 + T cells but the same proportion of CD4 + T cells with maternal PB. This finding was inconsistent with previous report which demonstrated that CD3 + and CD4 + T cells were increased in CB compared to PB [44]. More interestingly, our findings showed that CD3 + and CD4 + T cells in RPB were significantly lower than those in PB, which suggested that T cell-related immunity was suppressed at the maternal-fetal junction at the time of parturition.…”

Section: Discussioncontrasting

confidence: 99%

Maternal and Fetal CD4+CD25+CD127low/- Regulatory T Cells in Pregnancies with Gestational Diabetes, Preeclampsia, and Premature Rupture of Membranes

Zhao

Zhang

Sun

et al. 2020

Preprint

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Background Regulatory T cells (Tregs) play a crucial role in maternal-fetal tolerance, but little is known about the characteristic of Tregs in peripheral blood (PB), maternal-fetal interface and cord blood (CB) in normal and complicated pregnancies with preeclampsia (PE), gestational diabetes mellitus (GDM) and premature rupture of membranes (PROM). Methods PB, retro-placental blood (RPB), and CB were collected immediately after delivery in women with normal full-term pregnancy (NP), PE, GDM, and PROM. The proportion of CD4 + CD25 + CD127 low/- T cells (Tregs) and the expression of PD-1, GITR, HLA-G and CTLA-4 on T cell subsets were investigated by flow cytometric analysis. The data were analyzed based on sample origins (PB, RPB, and CB) and the obstetrical study groups (NP, PE, GDM, and PROM). Results The proportions of Tregs in PB, RPB, and CB from NP were significantly higher than the other obstetrical groups (P < 0.01, respectively). However no significant differences were present among the PE, GDM and PROM groups (P = NS). The proportion of PD-1 + and GITR + Tregs in RPB and PB as well as PD-1 + Tregs in CB from NP were significantly higher than those of the same origin in each obstetrical study group (P < 0.01, respectively). There were no differences in HLA-G + and CTLA-4 + Tregs between different origins in each obstetrical study group. In NP, the proportion of PD-1 + Tregs was significantly decreased in CB as compared to those of PB and RPB (P < 0.05, respectively). Among the four groups, the proportion of GITR + Tregs were significantly higher in PB as compared to those of CB and RPB (P < 0.01, respectively). The proportion of HLA-G + Tregs in PB was significantly lower than that of CB and RPB (P < 0.01, respectively). The proportion of CTLA-4 + Tregs had no significant differences (P = NS). Conclusions In conclusion, the proportion and characteristics of Tregs vary in the maternal, fetal and maternal-fetal junction at the time of delivery. The different feature and density of Tregs in maternal and fetal tissue may suggest the multiple and complicated roles of Tregs during pregnancy.

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Section: Discussioncontrasting

confidence: 99%

Maternal and Fetal CD4+CD25+CD127low/- Regulatory T Cells in Pregnancies with Gestational Diabetes, Preeclampsia, and Premature Rupture of Membranes

Zhao

Zhang

Sun

et al. 2020

Preprint

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“…In addition to participating in several metabolic functions, cytokines may assume modulatory, stimulatory or even inhibitory endocrine functions [15]. They act at very low concentrations, binding to specific cell membrane receptors and activating a cascade of metabolic reactions [16,17]. They may be useful markers for assessing the effects of physical exercise on the immune system.…”

Section: Discussionmentioning

confidence: 99%

Immune and Hormonal Response to High-intensity Exercise During Orienteering

et al. 2019

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Orienteering is an endurance sport that combines physical and cognitive activity, during which the athlete must complete a course with several points distributed over unknown terrain in the shortest possible time. A number of studies have investigated the body’s physiological adaptations to the stress caused during competition, but not the immunological changes. To that end, the present study evaluated the immunological, physiological and pathological responses in athletes performing high-intensity physical exercise during an orienteering race. The 30 athletes tested belonged to the elite orienteering category and participated in the regional championship. Cortisol levels were determined before and after the competition to assess stress response, as were the cytokines IL-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17 to evaluate the immune response. Cortisol levels increased after the competition, indicating a stress condition. IFN-γ, IL-6 and IL-10 levels also rose post competition. The results indicate that orienteers are exposed to high stress levels, and that this condition affects their immune and endocrine systems, triggering a predominantly anti-inflammatory response, likely an athlete’s mechanism of adaptation to the stress imposed by high-intensity physical exercise.

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“…Several studies have investigated the biochemical and immunological changes of HC related to maternal overweight and obesity. It is known that this condition is associated with low grade inflammation, confirmed by an increase in serum cytokines and inflammatory markers in maternal and fetal blood [ 14 , 17 , 65 , 66 ] and can be potentially aggravated during pregnancy, representing a disease predisposing factor both for the mother and also for the fetus (and later in life) [ 14 , 67 , 68 , 69 ].…”

Section: Proteomicsmentioning

confidence: 99%

“…It is known that breastfeeding can protect from the onset of obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) seems to have a peculiar role in newborn support and plays a protective role against allergic and chronic diseases, in addition to long-term benefits such as a reduction in systo-diastolic pressure and total cholesterol, decreased risk of Type 2 Diabetes Mellitus (DM2), overweight and obesity [ 14 , 15 , 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

2017

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Human Milk (HM) is the best source for newborn nutrition until at least six months; it exerts anti-inflammatory and anti-infective functions, promotes immune system formation and supports organ development. Breastfeeding could also protect from obesity, diabetes and cardiovascular disease. Furthermore, human colostrum (HC) presents a peculiar role in newborn support as a protective effect against allergic and chronic diseases, in addition to long-term metabolic benefits. In this review, we discuss the recent literature regarding “omics” technologies and growth factors (GF) in HC and the effects of pasteurization on its composition. Our aim was to provide new evidence in terms of transcriptomics, proteomics, metabolomics, and microbiomics, also in relation to maternal metabolic diseases and/or fetal anomalies and to underline the functions of GF. Since HC results are so precious, particularly for the vulnerable pre-terms category, we also discuss the importance of HM pasteurization to ensure donated HC even to neonates whose mothers are unable to provide. To the best of our knowledge, this is the first review analyzing in detail the molecular pattern, microbiota, bioactive factors, and dynamic profile of HC, finding clinical correlations of such mediators with their possible in vivo effects and with the consequent impact on neonatal outcomes.

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Changes in T-cell phenotype and cytokines profile in maternal blood, cord blood and colostrum of diabetic mothers

Abstract: The results obtained suggest that maternal hyperglycemia modifies the phenotypes of T cells and cytokines profile in maternal, cord blood and colostrum.

Cited by 28 publications

References 28 publications

Maternal and Fetal CD4+CD25+CD127low/- Regulatory T Cells in Pregnancies with Gestational Diabetes, Preeclampsia, and Premature Rupture of Membranes

Maternal and Fetal CD4+CD25+CD127low/- Regulatory T Cells in Pregnancies with Gestational Diabetes, Preeclampsia, and Premature Rupture of Membranes

Immune and Hormonal Response to High-intensity Exercise During Orienteering

“Omics” in Human Colostrum and Mature Milk: Looking to Old Data with New Eyes

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