Changes in T2 Relaxation Times Associated with Maturation of the Human Intervertebral Disk

Krueger, Eddy; Perry, J.O.; Wu, Yijing; Haughton, Victor M.

doi:10.3174/ajnr.a0546

Cited by 23 publications

(12 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, the mean T2 values in normal cervical discs was lower than those previously reported in healthy lumbar discs [15], [17], [22], [37]. This difference may due to the different biochemical properties characteristic of cervical and lumbar IVDs.…”

Section: Discussioncontrasting

confidence: 87%

“…Several studies have described the benefits of T2 mapping as a technique for biochemical and structural analysis of cartilage tissue of the spine, IVD and other joints [12]–[14]. Good correlation between T2 mapping values and water or PG content in lumbar IVD tissue has widely validated [15]–[19]. Increased disc water or glycosaminoglycan content, the primary component of PG, is associated with increased T2, whereas increased collagen content contributes to decreased T2 [16].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young Adults

et al. 2014

View full text Add to dashboard Cite

ObjectiveThe objective of this study was to evaluate the efficacy of quantitative T2 magnetic resonance imaging (MRI) for quantifying early cervical intervertebral disc (IVD) degeneration in asymptomatic young adults by correlating the T2 value with Pfirrmann grade, sex, and anatomic level.MethodsSeventy asymptomatic young subjects (34 men and 36 women; mean age, 22.80±2.11 yr; range, 18–25 years) underwent 3.0-T MRI to obtain morphological data (one T1-fast spin echo (FSE) and three-plane T2-FSE, used to assign a Pfirrmann grade (I–V)) and for T2 mapping (multi-echo spin echo). T2 values in the nucleus pulposus (NP, n = 350) and anulus fibrosus (AF, n = 700) were obtained. Differences in T2 values between sexes and anatomic level were evaluated, and linear correlation analysis of T2 values versus degenerative grade was conducted.FindingsCervical IVDs of healthy young adults were commonly determined to be at Pfirrmann grades I and II. T2 values of NPs were significantly higher than those of AF at all anatomic levels (P<0.000). The NP, anterior AF and posterior AF values did not differ significantly between genders at the same anatomic level (P>0.05). T2 values decreased linearly with degenerative grade. Linear correlation analysis revealed a strong negative association between the Pfirrmann grade and the T2 values of the NP (P = 0.000) but not the T2 values of the AF (P = 0.854). However, non-degenerated discs (Pfirrmann grades I and II) showed a wide range of T2 relaxation time. T2 values according to disc degeneration level classification were as follows: grade I (>62.03 ms), grade II (54.60–62.03 ms), grade III (<54.60 ms).ConclusionsT2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of cervical IVD degeneration and to create a reliable quantitative in healthy young adults.

show abstract

Section: Discussioncontrasting

confidence: 87%

Section: Introductionmentioning

confidence: 99%

Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young Adults

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Their findings suggested that ADC measurements may more sensitive in detecting early degenerative changes of IVDs. However, other studies have found the opposite [5], [20], [21], [22]. In our study, both ADC and T2 mean values were negatively correlated with age.…”

Section: Discussioncontrasting

confidence: 51%

Comparison of Apparent Diffusion Coefficient and T2 Relaxation Time Variation Patterns in Assessment of Age and Disc Level Related Intervertebral Disc Changes

Líu

Chen

et al. 2013

PLoS ONE

View full text Add to dashboard Cite

PurposeTo compare the variation patterns of ADC and T2 values in different age and intervertebral disc (IVD) levels, thus to identify their sensitivities in assessing age and disc level related IVDs changes.Materials and MethodsThe T2 and ADC values were recorded from 345 IVDs of 69 volunteers. Kendall's correlation analysis was used to identify the relationship between age and T2/ADC mean values respectively. The one-way analysis of variance (ANOVA) with post hoc analysis was then applied to test the differences of T2 and ADC values among different IVD levels and age groups, followed by linear regression analysis between age (<45 and >45 years) and T2/ADC mean values. This study was approved by the Ethics Committee of the Chinese Academy of Medical Sciences and the Peking Union Medical College Hospital.ResultsSignificant negative correlation was observed between age and T2/ADC mean values. The T2 and ADC values showed significant differences among IVD levels and among age groups except for T2 values in age group 1 (25–34 years) and group 2 (35–44 years), and for ADC values at L1–2 level. Both T2 and ADC values showed significant differences between young (age<45 years) and elderly group (age>45 years) at each IVD level. A linear relationship was observed between age and T2/ADC mean values in the elderly group as well as in the young group for the ADC mean values, while no such tendency was identified in the young group for the T2 mean values.ConclusionsADC values may be a more sensitive parameter than T2 in assessing age and disc level related intervertebral disc changes.

show abstract

“…14 Moreover, disk T2 varies with age, 18 magnitude, or duration of compression 21 and diurnal variation. 19 Therefore, T2 may serve as a potential quantitative and sensitive biomarker for detecting the IVDD at an early stage.…”

mentioning

confidence: 99%

MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation

Niu¹,

Yang²,

Wang³

et al. 2011

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

show abstract

Changes in T2 Relaxation Times Associated with Maturation of the Human Intervertebral Disk

Abstract: BACKGROUND AND PURPOSE: By calculating T2 relaxation times for intervertebral disks, we tested the hypothesis that disk water concentration increases between the first and second decades of life.

Cited by 23 publications

References 14 publications

Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young Adults

Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young Adults

Comparison of Apparent Diffusion Coefficient and T2 Relaxation Time Variation Patterns in Assessment of Age and Disc Level Related Intervertebral Disc Changes

MR Imaging Assessment of Lumbar Intervertebral Disk Degeneration and Age-Related Changes: Apparent Diffusion Coefficient versus T2 Quantitation

Contact Info

Product

Resources

About