Changes in the activities of three diagnostic enzymes in the heart of rats following the consumption of diets deficient in zinc and essential fatty acids

Adisa, Akinola; Odutuga, A.A.

doi:10.1080/15216549800204092

Cited by 4 publications

(4 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zn plays a protective role against homocysteine-induced peroxidation-based cardiac disorders [61], and its deficiency leads to unfavorable enzymatic alterations in the heart [62]. In our study, we found heart Zn contents to be higher in the PA group than in the KK group.…”

Section: Discussionsupporting

confidence: 48%

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

Skrypnik

Bogdański

Schmidt

et al. 2019

Biol Trace Elem Res

View full text Add to dashboard Cite

A range of interactions between gut microbiota and iron (Fe) metabolism is described. Oral probiotics ameliorate host’s iron status. However, this has been proven for single-strain probiotic supplements. Dose-dependence of beneficial probiotic supplementation effect on iron turnover remains unexplored. Our study aimed to investigate the effects of oral multispecies probiotic supplementation in two doses on iron status in rats. Thirty rats were randomized into three groups receiving multispecies probiotic supplement at a daily dose of 2.5 × 109 CFU (PA group, n = 10) and 1 × 1010 CFU (PB group, n = 10) or placebo (KK group, n = 10). After 6 weeks, rats were sacrificed for analysis, blood samples, and organs (the liver, heart, kidneys, spleen, pancreas, femur, testicles, duodenum, and hair) were collected. The total fecal bacteria content was higher in the PB group vs. PA group. Unsaturated iron-binding capacity was higher in the PB group vs. KK group. Serum Fe was lower in both PA and PB vs. KK group. Iron content in the liver was higher in the PB group vs. KK group; in the pancreas, this was higher in the PB group vs. the KK and PA group, and in the duodenum, it was higher in both supplemented groups vs. the KK group. A range of alterations in zinc and copper status and correlations between analyzed parameters were found. Oral multispecies probiotic supplementation exerts dose-independent and beneficial effect on iron bioavailability and duodenal iron absorption in the rat model, induces a dose-independent iron shift from serum and intensifies dose-dependent pancreatic and liver iron uptake.

show abstract

Section: Discussionsupporting

confidence: 48%

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

Skrypnik

Bogdański

Schmidt

et al. 2019

Biol Trace Elem Res

View full text Add to dashboard Cite

show abstract

“…Increased levels of these enzymes in the serum as herein observed could be an indication of some form of hepatic disease such as hepatitis and necrosis [16,17]. Though a lack of effect of EFA deficiency on the heart and lungs on the activity of ALT had been reported [18] contrary to the observations made in this study, this may indicate that the effect of this nutritional insult is divergent in various organs. In EFA deficiency, AST activity returned to control level, whereas ALT activity was reduced.…”

Section: Discussioncontrasting

confidence: 82%

Effect of low‐zinc status and essential fatty acids deficiency on the activities of aspartate aminotransferase and alanine aminotransferase in liver and serum of albino rats

Ajayi

Odutuga

2004

Nahrung

View full text Add to dashboard Cite

The effects of dietary deficiencies of zinc and essential fatty acids (EFAs) or both on aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were investigated in young growing rats. Four groups of albino rats were fed diets deficient in either EFA (4% hydrogenated coconut oil) or zinc (6 ppm) or both. The control diet was adequate in EFA (4% soybean oil) and zinc (100 ppm). The feeding trial lasted eight weeks and the activities of AST and ALT were determined in the liver and serum. EFA deficiency had no significant (p > 0.05) effect on liver AST. However, zinc and the double deficiencies depressed AST activity in the organ. Deficiencies of EFA, zinc and their combination depressed ALT activity in the liver significantly (p < 0.05) with a concomitant increase recorded in the serum. The data suggested alteration in endothelial permeability of the plasma membrane and thus leakage of membrane constituents in the tissue studied. It is therefore considered that these deficient diets may affect liver tissue negatively in view of the role of these enzymes in amino acid metabolism.

show abstract

“…The results were more intriguing because moderate zinc deficiency (5ppm) caused increased alkaline phosphatase (a membrane bound zinc metalloezyme) in the heart of rats indicating that either zinc binds the enzyme tightly or the metabolic pool of zinc in the heart is not freely exchangeable (Guthrie, 1989). Essential fatty acid deficiency on the other hand reduced the activities of aspartate aminotransferase, lactate dehydrogenase and glutamate dehydrogenase activities but increased that of alkaline phosphatase in the heart or lungs of rats (Adisa and Odutuga, 1998a;1998b). An interactive effect of zinc and essential fatty acids was indicated only for alkaline phosphatase activity.…”

Section: Essential Fatty Acids Zinc and Clinically Important Enzymesmentioning

confidence: 97%

“…Zinc and essential fatty acids seem to elicit divergent effects on diagnostic enzymes which are of both clinical and metabolic significance to the cell. Studies in our laboratory indicated that a chronic, severe deficiency of zinc might be needed to alter the activities of lactate dehydrogenase and glutamate dehydrogenase in the heart of rats even though they are zinc metalloenzymes (Adisa and Odutuga, 1998a;1998b). The results were more intriguing because moderate zinc deficiency (5ppm) caused increased alkaline phosphatase (a membrane bound zinc metalloezyme) in the heart of rats indicating that either zinc binds the enzyme tightly or the metabolic pool of zinc in the heart is not freely exchangeable (Guthrie, 1989).…”

Section: Essential Fatty Acids Zinc and Clinically Important Enzymesmentioning

confidence: 98%

Metabolic interactions between zinc and essential fatty acids in the mammalian organism

Adisa

Odutuga

1999

Nutrition &Amp; Food Science

View full text Add to dashboard Cite

Zinc and essential fatty acid deficiencies manifest similar syndromes provoking investigations into the mechanisms underlying their metabolic interactions. This article presents a lucid and concise review of literature on the possible connection between these important dietary nutrients as exemplified by the role of zinc in modulating intestinal lipid transport and prostaglandins metabolisms as well as maintenance of membrane structural and functional integrity. Reports of investigations on zinc and essential fatty acid deficiencies, regarding their pleitropic effects on clinically important enzymes, from the laboratory of the authors were also considered.

show abstract

Changes in the activities of three diagnostic enzymes in the heart of rats following the consumption of diets deficient in zinc and essential fatty acids

Cited by 4 publications

References 10 publications

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

The Effect of Multispecies Probiotic Supplementation on Iron Status in Rats

Effect of low‐zinc status and essential fatty acids deficiency on the activities of aspartate aminotransferase and alanine aminotransferase in liver and serum of albino rats

Metabolic interactions between zinc and essential fatty acids in the mammalian organism

Contact Info

Product

Resources

About