Changes in the cerebral arteriovenous oxygen content difference by surgical incision are similar during sevoflurane and isoflurane anaesthesia

Inada, Takefumi; Shingu, Koh; Uchida, Masashi; Kawachi, Shoji; Tsushima, Kohichi; Niitsu, Tateki

doi:10.1007/bf03011903

Cited by 19 publications

(7 citation statements)

References 27 publications

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“…Cerebrovascular response. The cerebrovascular response to changes in carbon dioxide concentration in neurosurgical patients is well preserved with sevoflurane (38,131,165,220). The relationship between cerebral blood flow and arterial carbon dioxide during sevoflurane anesthesia in neurosurgical patients was measured (Fig.…”

Section: Neurological Effectsmentioning

confidence: 99%

“…To assess changes in cerebral arteriovenous oxygen content and carbon dioxide concentration, 1.3 MAC sevoflurane or isoflurane was administered to neurosurgical patients with supratentorial tumors (131). A statistically significant reduction in cerebral arteriovenous oxygen content was observed on incision in patients treated with sevoflurane and CNS Drug Reviews, Vol.…”

Section: Neurological Effectsmentioning

confidence: 99%

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Sevoflurane: Approaching the Ideal Inhalational Anesthetic A Pharmacologic, Pharmacoeconomic, and Clinical Review

2001

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Sevoflurane is a safe and versatile inhalational anesthetic compared with currently available agents. Sevoflurane is useful in adults and children for both induction and maintenance of anesthesia in inpatient and outpatient surgery. Of all currently used anesthetics, the physical, pharmacodynamic, and pharmacokinetic properties of sevoflurane come closest to that of the ideal anesthetic (200). These characteristics include inherent stability, low flammability, non-pungent odor, lack of irritation to airway passages, low blood:gas solubility allowing rapid induction of and emergence from anesthesia, minimal cardiovascular and respiratory side effects, minimal end-organ effects, minimal effect on cerebral blood flow, low reactivity with other drugs, and a vapor pressure and boiling point that enables delivery using standard vaporization techniques. As a result, sevoflurane has become one of the most widely used agents in its class.

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Section: Neurological Effectsmentioning

confidence: 99%

Section: Neurological Effectsmentioning

confidence: 99%

Sevoflurane: Approaching the Ideal Inhalational Anesthetic A Pharmacologic, Pharmacoeconomic, and Clinical Review

2001

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“…They also found that ICP was unchanged from baseline to 0.5, 1.0 and 1.5% sevoflurane. According to other clinical studies, the cerebral autoregulation (CA) was found to be intact during sevoflurane anaesthesia (9) and C02-reactivity was well preserved (9,(11)(12)(13).…”

mentioning

confidence: 92%

“…Clinical studies concerning the cerebrovascular effects of sevoflurane are, however, few. Only seven studies are available (9)(10)(11)(12)(13)(14)(15). Low CBF values were reported in patients with ischaemic cerebrovascular disease during 1.5% sevoflurane and 33% nitrous oxide when compared with the awake value (9), and in healthy patients mean middle cerebral artery flow velocity (Vmca) was decreased from the awake state during 1.2 MAC sevoflurane (11).…”

mentioning

confidence: 99%