Changes in the Concentrations of Acute Phase Proteins in Calves during the first Month of Life / Promene Koncentracije Proteina Akutne Faze Tokom Prvog Meseca Života Teladi

Abstract

The objective of this study was to describe the physiological changes in the concentrations of acute phase proteins (APPs) in calves during the fi rst month of life, including pre-, postcolostral and milk feeding period. Seven clinically healthy calves were used in this study. Calves received colostrum and whole milk from their dams. The fi rst blood sampling was performed before colostrum intake (day 0) and then at 1, 2, 7, 14 and 30 days of age. Blood serum was analyzed for the concentrations of haptoglobin (Hp), serum amyloid A (SAA), α1-acid glycoprotein (AGP), ceruloplasmin (Cp), and albumin (Alb). The results showed signifi cant changes in the serum concentrations of Hp, SAA and Cp (P<0.001, P<0.01, P<0.01). Their lowest concentrations were found after birth, and a gradual increase was observed after colostrum intake until day 7 of life. Another trend was observed in the concentrations of albumin with a more marked decrease of values 1 day after colostrum intake and subsequent signifi cant increase of values until the end of the fi rst month of age (P<0.001). Sampling time had no signifi cant effect on the concentrations of AGP. The values observed at birth and on day 1 of life were relatively stable. The concentrations of AGP increased slightly from day 2 until the end of the fi rst month of age. These results suggest that the concentrations of APPs in the neonatal period are infl uenced by colostrum intake and age. This should be taken into consideration for the precise interpretation of these analytes in young animals.

Passive immune transfer, health, pre-weaning performance, and metabolism of dairy calves fed a colostrum supplement associated with medium-quality maternal colostrum

“…Results of albumin concentration corroborate those of Tothova et al (2015), who observed decreasing concentrations of albumin during the first week, followed by increasing concentrations until 30 days of age, when experimental period ended. Glucose concentrations were expected to decrease and those of BHBA to increase as starter intake increases and rumen develops.…”

Cryptosporidium outbreak in calves on a large dairy farm: Effect of treatment and the association with the inflammatory response and short-term weight gain

“…In cases of viral (foot-and-mouth disease and bovine respiratory syncytial virus) or parasitic (Eimeria and Cryptosporidium) infections, APP concentrations can increase in domestic ruminants' blood serum (Orro et al, 2011;Pourjafar et al, 2011;Stenfeldt et al, 2011;Lassen et al, 2015). In neonatal calves, APPs go through significant changes during first 2 to 3 weeks of life (Orro et al, 2008;Tóthová et al, 2015), suggesting that APPs have a role in the adaptation of neonate calves to the new environment. In reindeer calves, lambs, and beef calves, high concentrations of SAA measured in the second week of life have been associated with lower weight gain recorded many months later (Orro et al, 2006;Peetsalu et al, 2013;Seppä-Lassila et al, 2015, 2017.…”

Cinética da proteína total, ceruloplasmina e fibrinogênio em cordeiros Santa Inês durante os primeiros cinco meses de vida

“…Este processo de adaptação foi utilizado para justificar aumentos na concentração de PFA em bezerros e caprinos nos primeiros meses de vida (Tóthová et al, 2015;Ulutas et al, 2017). Por outro lado, o colostro pode exercer influência sobre a concentração sérica de PFA no período neonatal (Tóthová et al, 2015). O efeito precoce de doenças não deve ser descartado, já que o status de higidez nem sempre reflete em concentrações baixas de PFA.…”

“…Apesar da promessa de grande aplicabilidade no diagnóstico, prognóstico e monitoramento da saúde animal, o uso das PFA na rotina laboratorial depende do fornecimento de valores basais em diferentes condições fisiológicas para serem usadas como de normalidade ou mesmo de referência (Eckersall et al, 2000). O estudo do comportamento das PFA é fundamental para a compreensão das alterações ao longo do desenvolvimento dos animais, visto que em bezerros foi possível observar aumentos na concentração sérica de PFA nos primeiros dias de vida (Tóthová et al, 2015), assim como em cabritos (Ulutas et al, 2017).…”