Changes in the Distribution of theα3 Na+/K+ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development

McFarland, Rebecca; Zanjani, Hadi Shojaeian; Mariani, Jean; Vogel, Michael W.

doi:10.1155/2014/152645

Cited by 4 publications

(2 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is established that there is a two-side relationship between Na + /K + -ATP-ase activity and concentration of Na + and K + ions. In particular, Na + /K + -ATP-ase is the main enzyme regulating the concentration gradient of Na + and K + ions in intra-and extra-cellular areas; But mentioned ions, in turn, play the role of enzyme's regulators [1] [16].…”

Section: Resultsmentioning

confidence: 99%

Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)

Alibegashvili¹,

Veshapidze²,

Ramishvili³

et al. 2015

JCT

View full text Add to dashboard Cite

The changes of blood erythrocytes transport function in patients with prostate adenocarcinoma have been studied according to alterations in Na + /K +-ATP-ase activity and permeability of Na + and K + ions, before and after the plastic orchiectomy. The results of the study revealed that activity of Na + /K +-ATP-ase was increased compared with the data before the orchiectomy, but this parameter was reduced compared with control group. The increased amounts of the Na + as well as K + ions were also observed in the extracellular area compared with the same data before the orchiectomy. The amount of cholesterol, after plastic orchiectomy, was reduced compared with the data gained before orchiectomy, but the data were greater than those of the control group. It may be presumed that one of the reasons for change of Na + /K +-ATP-ase activity is variation of cholesterol content in erythrocyte membrane. Changes of the active transport system, in turn, affect the transport function of the erythrocyte membrane. In spite of surgical intervention, full recovery of patients does not take place after the plastic orchiectomy. Comparative normalization and approaching to the control group of the given indices in post-operation period (~6 months after surgery) indicate strengthening of the immune system and correspondingly-protective abilities of an organism, which was proved by the anamneses of patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)

Alibegashvili¹,

Veshapidze²,

Ramishvili³

et al. 2015

JCT

View full text Add to dashboard Cite

show abstract

“…Mcc −/− enterocytes using both in vivo and in vitro approaches (Cowen and Thrasivoulou, 1992;McFarland et al, 2014).…”

Section: Intestinal Permeability In the MCCmentioning

confidence: 99%

Mutated in colorectal cancer (MCC) : a novel centrosomal protein involved in intestinal homeostasis and disease

Tomaz¹

View full text Add to dashboard Cite

Deletion of the GluRδ2 Receptor in the Hotfoot Mouse Mutant Causes Granule Cell Loss, Delayed Purkinje Cell Death, and Reductions in Purkinje Cell Dendritic Tree Area

2015

View full text Add to dashboard Cite

Recent studies have found that in the cerebellum, the δ2 glutamate receptor (GluRδ2) plays a key role in regulating the differentiation of parallel fiber-Purkinje synapses and mediating key physiological functions in the granule cell-Purkinje cell circuit. In the hotfoot mutant or GluRδ2 knockout mice, the absence of GluRδ2 expression results in impaired motor-related tasks, ataxia, and disruption of long-term depression at parallel fiber-Purkinje cell synapses. The goal of this study was to determine the long-term consequences of deletion of GluRδ2 expression in the hotfoot mutant (GluRδ2 ) on Purkinje and granule cell survival and Purkinje cell dendritic differentiation. Quantitative estimates of Purkinje and granule cell numbers in 3-, 12-, and 20-month-old hotfoot mutants and wild-type controls showed that Purkinje cell numbers are within control values at 3 and 12 months in the hotfoot mutant but reduced by 20 % at 20 months compared with controls. In contrast, the number of granule cells is significantly reduced from 3 months onwards in GluRδ2 mutant mice compared to wild-type controls. Although the overall structure of Purkinje cell dendrites does not appear to be altered, there is a significant 27 % reduction in the cross-sectional area of Purkinje cell dendritic trees in the 20-month-old GluRδ2 mutants. The interpretation of the results is that the GluRδ2 receptor plays an important role in the long-term organization of the granule-Purkinje cell circuit through its involvement in the regulation of parallel fiber-Purkinje cell synaptogenesis and in the normal functioning of this critical cerebellar circuit.

show abstract

Changes in the Distribution of theα3 Na⁺/K⁺ATPase Subunit in Heterozygous Lurcher Purkinje Cells as a Genetic Model of Chronic Depolarization during Development

Cited by 4 publications

References 45 publications

Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)

Change of Erythrocytes Transport Function in Blood of Men with Prostate Adenocarcinoma (before and after Plastic Orchiectomy)

Mutated in colorectal cancer (MCC) : a novel centrosomal protein involved in intestinal homeostasis and disease

Deletion of the GluRδ2 Receptor in the Hotfoot Mouse Mutant Causes Granule Cell Loss, Delayed Purkinje Cell Death, and Reductions in Purkinje Cell Dendritic Tree Area

Contact Info

Product

Resources

About