Changes in the expression of the nerve growth factor receptors TrkA and p75 LNGR in the rat thymus with ageing and increased nerve growth factor plasma levels

García‐Suárez, Olivia; Germanà, Antonino; Hannestad, Jonas; Pérez-Pérez, M.; Esteban, I.; Naves, F.J.; Vega, J.A.

doi:10.1007/s004419900133

Cited by 32 publications

(27 citation statements)

References 32 publications

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“…NTR is expressed by medullar ones and, possibly, dendritic cells (García-Suá rez et al, 2000a;Hannestad et al, 1997;Labouryie et al, 1997;Parrens et al, 1998;Pescarmona et al, 1993). NGF is produced by medullar TEC (Aloe et al, 1997;Laurenzi et al, 1994;Screpanti et al, 1992).…”

Section: Neurotrophinsmentioning

confidence: 97%

Involvement of growth factors in thymic involution

García‐Suárez

Pérez-Pérez

Germanà

et al. 2003

Microscopy Res & Technique

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The thymus undergoes an age-dependent degenerative process which is mainly characterized by a progressive loss of lymphoid tissue. Thymic involution is particularly important in relation to immunosenescence and its various associated diseases; this fact has prompted many studies aimed at understanding the causes and mechanisms of thymic degeneration which may, ultimately, lead to the possibility of manipulating it. In this sense, one of the aspects which has deserved most attention is the thymic microenvironment, and more precisely, the many growth factors to which the cells present in the organ are exposed. Thus, the levels of several of such factors have been reported to undergo age-dependent changes in the thymus, which may point at an influence on the regression of the organ. In this article we consider which growth factors and growth factor receptors occur in the vertebrate thymus. Then, focusing on those whose influences are better documented, i.e., neurotrophins, cytokines and IGFs, we discuss their potential role in the organ and the possibility of their being involved in thymic involution.

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Section: Neurotrophinsmentioning

confidence: 97%

Involvement of growth factors in thymic involution

García‐Suárez

Pérez-Pérez

Germanà

et al. 2003

Microscopy Res & Technique

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“…TrkA is also expressed in epithelial subcapsular and medullar cells [73,75,80,81], in peripheral epithelial cells of Hassal’s bodies and in interdigitating reticular cells of the medulla [79]. The latter cells also express p75NTR, which is also expressed in periarteriolar macrophages, endothelial sinusal cells and nerve endings [79,80,81,82]. TrkA expression seems to be necessary for the normal development of the thymus, as demonstrated in TrkA-deficient mice, in which the thymus is smaller, with no clear delimitation between the cortex and the medulla, and the thymocyte density is lower [61].…”

Section: Expression Of Ngf Receptors In the Immune Systemmentioning

confidence: 99%

“…In the final stages of embryo development and in the early post-natal days the expression of TrkA and p75NTR in the rat thymus is maximal, and then declines with age [81] in parallel with age-dependent changes in medullar epithelial cells [82]. Interestingly, in normal human thymuses the epithelial cells exhibit a TrkA positive-p75NTR negative phenotype but a switch to a TrkA negative-p75NTR positive phenotype has been described in malignant epithelial cell tumors [73,83].…”

Section: Expression Of Ngf Receptors In the Immune Systemmentioning

confidence: 99%

NGF and Its Receptors in the Regulation of Inflammatory Response

Minnone

Benedetti

Bracci-Laudiero

2017

IJMS

239

163

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There is growing interest in the complex relationship between the nervous and immune systems and how its alteration can affect homeostasis and result in the development of inflammatory diseases. A key mediator in cross-talk between the two systems is nerve growth factor (NGF), which can influence both neuronal cell function and immune cell activity. The up-regulation of NGF described in inflamed tissues of many diseases can regulate innervation and neuronal activity of peripheral neurons, inducing the release of immune-active neuropeptides and neurotransmitters, but can also directly influence innate and adaptive immune responses. Expression of the NGF receptors tropomyosin receptor kinase A (TrkA) and p75 neurotrophin receptor (p75NTR) is dynamically regulated in immune cells, suggesting a varying requirement for NGF depending on their state of differentiation and functional activity. NGF has a variety of effects that can be either pro-inflammatory or anti-inflammatory. This apparent contradiction can be explained by considering NGF as part of an endogenous mechanism that, while activating immune responses, also activates pathways necessary to dampen the inflammatory response and limit tissue damage. Decreases in TrkA expression, such as that recently demonstrated in immune cells of arthritis patients, might prevent the activation by NGF of regulatory feed-back mechanisms, thus contributing to the development and maintenance of chronic inflammation.

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“…A great variety of factors of neural, endocrine origin, as well as growth factors, cytokines, chemokines, acting in an endocrine, paracrine, or autocrine manner modulate the activity of medullary TEC Fabris et al, 1997;Garcia-Suarez et al, 2000). It is worth noticing, however, that in parallel to the progressing age modification of proliferation, differentiation and the secretory activity of target cells may in this way be down-or up-regulated in response to the composition of various signals provided by their local environment.…”

Section: Medullamentioning

confidence: 99%

Thymic epithelial cells in age‐dependent involution

Brelińska

2003

Microscopy Res & Technique

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Aging involves morphological and functional alterations within the microenvironment of the thymus where heterogenous populations of thymic epithelial cells (TEC) play the main roles. The studies performed to date on thymic involution signalize a disturbed interaction between individual thymic compartments that disrupt thymocyte-TEC interactions and, as a sequele, disturb differentiation of both TEC and thymocytes. The process of aging affects the various subsets of TEC at different periods of life. Changes in different subsets of TEC are documented on the basis of their phenotypical characteristics, involving morphological analysis and immunocytochemistry. The character and kinetics of changes in TEC are typical for individual subsets and probably sex-dependent. In the course of life, the involutionary changes, expressed by disorganised thymic structure and function, are accompanied by changes in medullary TEC, manifested by alterations in the differentiation process of the cells. In parallel, at the same stage of individual life, the aging process induces increased proliferative and secretory activity of subseptal TEC, which seem to functionally replace medullary TEC. Structural and phenotypic modifications of TEC are locally controlled by complex sets of different factors and seem to represent a morphological adaptation of the gland to the process of aging. Microsc. Res. Tech. 62:488-500, 2003.

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Changes in the expression of the nerve growth factor receptors TrkA and p75 LNGR in the rat thymus with ageing and increased nerve growth factor plasma levels

Cited by 32 publications

References 32 publications

Involvement of growth factors in thymic involution

Involvement of growth factors in thymic involution

NGF and Its Receptors in the Regulation of Inflammatory Response

Thymic epithelial cells in age‐dependent involution

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