2020
DOI: 10.21474/ijar01/11433
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Changes in the Expression of Notch and Hif-1α Signaling Molecules in Prostate Cancer Progression

Abstract: Objective: To explore the expression and clinical significance of Notch and HIF-1α signaling molecules in the progression of prostate cancer. Method: A total of 68 cases with prostate cancer were enrolled to detecting the expression level of Notch1, HIF-1α and Hes1 mRNA by qRT-PCR, in which the protein expression was measured by western blotting and immunohistochemistry staining, respectively. Correlation between molecules above and clinical pathological parameters were further analyzed. Results: Both Notch si… Show more

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