Changes in the hormone and lipid profile of obese adolescent Saudi females with acne vulgaris

Abstract

Acne vulgaris is a multifactorial disease affecting a majority of the adolescent population. The objective of this study was to test for a correlation between fasting serum lipid profiles and levels of testosterone, insulin, leptin, and interleukin 1-β (IL-1β) and the incidence of severe acne vulgaris in obese adolescent females. Four groups of adolescent females were studied: obese with acne, obese without acne, non-obese with acne, and non-obese without acne. Obese females with acne, compared to obese females without acne and non-obese subjects, had significantly higher serum triglycerides, low-density lipoprotein cholesterol and apolipoprotein-B (apo-B) (mean ± SD: 197 ± 13.7 vs 171 ± 11.5, 128 ± 8.3 vs 116 ± 7.7, 96 ± 13.7 vs 85 ± 10.3 mg/dL, respectively) but significantly lower high-density lipoprotein cholesterol and apo-A1 levels (40 ± 3.3 vs 33 ± 3.5 and 126 ± 12 vs 147 ± 13 mg/dL). Serum testosterone, insulin and leptin levels were significantly higher in obese subjects with or without acne compared to non-obese females with or without acne (3 ± 0.5 vs 2.1 ± 0.47, 15.5 ± 3.3 vs 11.6 ± 3, 0.9 ± 0.2 vs 0.6 ± 0.15 nmol/ mL, respectively). Serum IL-1β was significantly elevated in obese and non-obese subjects with acne compared to subjects without acne; in those without acne, these levels were higher in obese than non-obese subjects (2.4 ± 0.2, 1.4 ± 0.1 vs 1.8 ± 0.12 and 1.3 ± 0.11 pg/mL, respectively). Our results indicate that there is a relationship between obesity (BMI >27) and acne. By early recognition, the etiology and treatment protocol of acne may prevent unwanted conditions.

Structure and function of the human skin microbiome

“…Here, it is speculated that high glycemic loads in Western diet could lead to increased androgens, increased insulin-like growth-factor 1, and altered retinoid signaling [44, 45]. In this context, such variables may also influence the skin microbiome.…”

The aetiopathogenesis of acne vulgaris – what's new?

“…Abulnaj's studies of 2009 [67] demonstrated the significantly higher level of IL-1 beta in patients with acne. Similar results were obtained in a group of obese women and women without acne.…”

Hubungan Antara Kelainan Siklus Menstruasi Dengan Kejadian Akne Vulgaris Pada Santriwati Sma Islam Terpadu Nur Hidayah Kartasura

“…Salah satu tanda kematuran pubertas adalah munculnya AV akibat peningkatan sebum dan sekresi hormon androgen (Herane dan Ando, 2003).Hormon androgen yang meningkat pada masa remaja dapat menyebabkan siklus menstruasi yang tidak teratur (Abulnaja, 2009).Ketidakteraturan siklus menstruasi juga disebabkan oleh ketidakseimbangan hormon estrogen dan progesteron (Qomaruddin, 2005). Hormon estrogen dan progesteron merupakan pemacu terjadinya AV sebelum menstruasi.…”