Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer

Osipyants, A. I.; Knyazev, E N; Galatenko, A. V.; Nyushko, K. M.; Galatenko, Vladimir; Shkurnikov, M. Yu.; Alekseev, B. Ya.

doi:10.1007/s10517-017-3620-6

Cited by 21 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, this miRNA is frequently down-regulated in KiC tissues and its restoration was considered as a potential therapeutic strategy for KiC therapy 75 . The up-regulation of hsa-mir-19b-3p demonstrated highest diagnostic sensitivity and specificity in PrC 76 . It has been found that hsa-mir-19b-3p is highly expressed in BlC 77 and its enrichment has been described as being directly associated with KiC 78 .…”

Section: Discussionmentioning

confidence: 95%

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Polo

Marchese

Petro

et al. 2018

Sci Rep

View full text Add to dashboard Cite

Arsenic and arsenic-derivative compounds, named as arsenicals, represent a worldwide problem for their effect on the human health and, in particular, for their capability to increase the risk of developing cancer such as kidney, bladder and prostate cancer. The main source of arsenical exposure is drinking water. Nowadays, it is well known that the chronic exposure to arsenicals leads to a series of epigenetic alterations that have a role in arsenic-induced effects on human health including cancer. Based on these observations, the aim of our study was to select by network analysis the genes/proteins/miRNAs implicated in kidney, bladder and prostate cancer development upon arsenical exposure. From this analysis we identified: (i) the nodes linking the three molecular networks specific for kidney, bladder and prostate cancer; (ii) the relative HUB nodes (RXRA, MAP3K7, NR3C1, PABPC1, NDRG1, RELA and CTNNB1) that link the three cancer networks; (iii) the miRNAs able to target these HUB nodes. In conclusion, we highlighted a panel of potential molecules related to the molecular mechanisms of arsenical-induced cancerogenesis and suggest their utility as biomarkers or therapeutic targets.

show abstract

Section: Discussionmentioning

confidence: 95%

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Polo

Marchese

Petro

et al. 2018

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Several panels of miRNAs were already introduced to ESCC detection [ 102 ]. Plasma levels of miRNA pair miR-19b-3b and miR-297-5p were found to be diagnostically significant for prostate cancer [ 103 ]. A combination of exosomal miR-126-3p, miR-449a-5p, and miR-34b-5p was adopted to the diagnosis of ccRCC, and combination of miR-126-3p and miR-34b-5p could identify carcinoma and benign injury [ 71 ].…”

Section: The Disadvantage and Limitation Of Circulating Mirnas As Diamentioning

confidence: 99%

Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

et al. 2018

View full text Add to dashboard Cite

MicroRNAs are endogenous single-stranded non-coding small RNA molecules that can be secreted into the circulation and exist stably. They usually exhibit aberrant expression under different physiological and pathological conditions. Recently, differentially expressed circulating microRNAs were focused on as potential biomarkers for cancer screening. We herein review the role of circulating microRNAs for cancer diagnosis, tumor subtype classification, chemo- or radio-resistance monitoring, and outcome prognosis. Moreover, circulating microRNAs still have several issues hindering their reliability for the practical clinical application. Future studies need to elucidate further potential application of circulating microRNAs as specific and sensitive markers for clinical diagnosis or prognosis in cancers.

show abstract

“…MiRNA expression levels are usually altered and associated with pathological conditions [ 39 , 40 ]. There are more distinct miRNAs expressed in the brain than in any other organ, implying a complex regulation network [ 41 – 43 ].…”

Section: Introductionmentioning

confidence: 99%

Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1

et al. 2018

View full text Add to dashboard Cite

BackgroundCircular RNAs (circRNAs) are widely expressed in mammals and can regulate the development and progression of human tumors. has_circ_0015758 (circ-CFH) is an exon circRNA transcript from the GRCh37/hg19 fragment of chromosome 1 and is homologous to the protein-coding gene complement factor H (CFH). Currently, the function of circ-CFH in glioma remains unclear.Material/MethodsIn our study, circ-CFH, miR-149, and Akt1 mRNA expression levels were analyzed by qRT-PCR assays. To investigate the function of circ-CFH in cell proliferation, circ-CFH knockdown models were established by using circ-CFH siRNAs. Cell proliferation abilities were measured by CCK-8 and colony formation assays and in vivo experiments. In addition, the interaction between circ-CFH and miR-149 was assessed by luciferase reporter assays.ResultsCirc-CFH expression was significantly upregulated in glioma tissue and was correlated with tumor grade. Circ-CFH expression levels were also markedly higher in U251 and U373 glioma cell lines. Circ-CFH knockdown inhibited cell proliferation and colony formation abilities. Luciferase assays indicated that circ-CFH functions as a miR-149 sponge and inhibits its function in U251 and U373 cells. Subsequently, AKT1 was identified as a direct target of the circ-CFH/miR-149 axis.ConclusionsCirc-CFH promotes glioma progression by sponging miR-149 and regulating the AKT1 signaling pathway. The circ-CFH/miR-149/AKT1 regulation axis may be a potential target for glioma therapy.

show abstract

Changes in the Level of Circulating hsa-miR-297 and hsa-miR-19b-3p miRNA Are Associated with Generalization of Prostate Cancer

Cited by 21 publications

References 12 publications

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Identifying a panel of genes/proteins/miRNAs modulated by arsenicals in bladder, prostate, kidney cancers

Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage

Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1

Contact Info

Product

Resources

About